GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms MaxiK; 5730414M22Rik; Slo; BK channel alpha subunit; BKCa; Slo1; mSlo1
Chromosome 14
Genetic Map Distance 12.92 cM
RefSeq Accessions NM_001253358; NM_001253359; NM_001253360; NM_001253361; NM_001253362; NM_001253363; NM_001253364; NM_001253365; NM_001253366; NM_001253367; NM_001253368; NM_001253369; NM_001253370; NM_001253371; NM_001253372; NM_001253373; NM_001253374; NM_001253375; NM_001253376; NM_00125
NCBI Entrez Gene 16531 at chr14:24117983-24823427 (mm9) / chr14:23292291-24004927 (mm10)
Ensembl Gene ENSMUSG00000063142
VEGA Gene
MGI Gene MGI:99923
Mouse Protein (9)
UniProt ID Description Length (AA) Predicted # TMs
Q08460 Calcium-activated potassium channel subunit alpha-1 1209 6
C3VLD3 Large conductance Ca2+-activated potassium channel DEC variant 1 1195 6
Q3UQ23 Putative uncharacterized protein (Fragment) 773 6
A5JHE0 KCNMA1 (Fragment) 101 0
A5JHH3 KCNMA1 (Fragment) 34 0
Q3TSL8 Putative uncharacterized protein (Fragment) 327 0
Q3UXG3 Putative uncharacterized protein (Fragment) 186 0
Q9EQ26 Ca2+ voltage sensitive potassium channel SloII87 variant (Fragment) 28 0
Q9EQ27 Ca2+ voltage sensitive potassium channel STREX variant (Fragment) 57 0
Pfam Domains Ion_trans; TrkA_N; BK_channel_a
Mouse alleles (5)
Allele Name Allele Type
Kcnma1tm1e(KOMP)Wtsi KOMP-CSD-Project
Kcnma1tm1a(KOMP)Wtsi KOMP-CSD-Project
Kcnma1tm1Ruth Targeted (knock-out)
Kcnma1tm1Rwa Targeted (knock-out)
Kcnma1tm2.1Ruth Targeted (Floxed/Frt)
Human Homolog KCNMA1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1)
Human synonyms bA205K10.1; BKTM; KCa1.1; MaxiK; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
Human cytoband 10q22.3
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (3)
ENSGALG00000004980 (KCMA1_CHICK) encoding ENSGALP00000007968
ENSGALG00000004980 (KCMA1_CHICK) encoding ENSGALP00000039702
ENSGALG00000004980 (KCMA1_CHICK) encoding ENSGALP00000039705
Gene Ontology
Biological Process (70) micturition; micturition; locomotor rhythm; response to estrogen stimulus; protein homotetramerization; ion transmembrane transport; ion transmembrane transport; vasodilation; regulation of aldosterone metabolic process; negative regulation of cell volume; negative regulation of cell volume; saliva secretion; regulation of ion transmembrane transport; regulation of ion transmembrane transport; auditory receptor cell differentiation; response to osmotic stress; regulation of membrane potential; regulation of membrane potential; regulation of membrane potential; regulation of membrane potential; protein homooligomerization; cellular potassium ion homeostasis; neuromuscular process controlling balance; neuromuscular process controlling balance; auditory receptor cell differentiation; cell maturation; potassium ion transmembrane transport; potassium ion transmembrane transport; potassium ion transmembrane transport; potassium ion transmembrane transport; potassium ion transmembrane transport; potassium ion transmembrane transport; response to hypoxia; potassium ion transmembrane transport; response to hypoxia; potassium ion transmembrane transport; response to hypoxia; potassium ion transmembrane transport; response to pH; potassium ion transmembrane transport; adult walking behavior; potassium ion transmembrane transport; adult walking behavior; potassium ion transmembrane transport; synaptic transmission; potassium ion transmembrane transport; sensory perception of sound; potassium ion transmembrane transport; sensory perception of sound; response to carbon monoxide; positive regulation of apoptotic process; potassium ion transport; response to calcium ion; potassium ion transport; response to calcium ion; potassium ion transport; response to corticosteroid stimulus; circadian rhythm; regulation of action potential in neuron; regulation of vasodilation; sensory perception of sound; transport; relaxation of vascular smooth muscle; ion transport; micturition; ion transport; smooth muscle contraction involved in micturition; smooth muscle contraction involved in micturition; transmembrane transport; eye blink reflex
Cellular Component (23) dendrite; plasma membrane; voltage-gated potassium channel complex; voltage-gated potassium channel complex; plasma membrane; plasma membrane; integral to membrane; integral to membrane; integral to membrane; apical plasma membrane; apical plasma membrane; endoplasmic reticulum; neuronal cell body; perinuclear region of cytoplasm; presynaptic active zone membrane; membrane; membrane; caveola; external side of plasma membrane; cytoplasmic part; terminal button; postsynaptic membrane; external side of plasma membrane
Molecular Function (27) protein homodimerization activity; large conductance calcium-activated potassium channel activity; large conductance calcium-activated potassium channel activity; large conductance calcium-activated potassium channel activity; actin binding; voltage-gated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel activity; nucleotide binding; calcium-activated potassium channel activity; calcium-activated potassium channel activity; calcium-activated potassium channel activity; calcium-activated potassium channel activity; calcium-activated potassium channel activity; calcium-activated potassium channel activity; calcium-activated potassium channel activity; calcium-activated potassium channel activity; calcium-activated potassium channel activity; potassium channel activity; protein complex binding; potassium channel activity; metal ion binding; ion channel activity; ion channel activity; voltage-gated ion channel activity; protein binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
26
165
828
872
1002
1124
Cochlea GFP+ cells
1
18
30
46
154
NA
Utricle GFP- cells
2
39
36
1
3
110
Cochlea GFP- cells
0
30
16
12
191
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
40
GFP+
388
9.57
0.0297
Utricle
351
Cochlea
50
0.14
0.285
Embryonic
35
Postnatal
316
8.92
0.000664
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17304012 278.44 ± 22.18 150.47 ± 21.48 [109.46] 0.54 0.195
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
58
58
60
46
No bFGF
116
101
124
87
EGF
64
47
48
53
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
46
No bFGF
87
1.87
1
bFGF
46
EGF
53
1.15
0.618
No bFGF
87
EGF
53
0.62
0.0163
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1424848_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 619.53 245.62 1450.1 1553.72 1007.9 471.95
Replicate 1 Call P P P P P P
Replicate 2 610.38 331.12 1884.67 1019.7 1705.56 697.63
Replicate 2 Call P P P P P P
Replicate 3 647.48 482.46 1767.99 1702.92 843.44 1326.06
Replicate 3 Call P P P P P P
Replicate 4 1711 1546.52 992.52 1670.93
Replicate 4 Call P P P P
Mean 625.8 353.07 1703.44 1455.72 1137.36 1041.64
Standard Deviation 19.33 119.94 183.71 299.48 386 553.71
Log2 Mean 9.29 8.41 10.73 10.48 10.1 9.85
Log2 Standard Deviation 0.04 0.49 0.16 0.33 0.44 0.84
 
Vestibular ganglion
Replicate 1 1493.77 812.86 695.47 299.72 344.33 374.62
Replicate 1 Call P P P P P P
Replicate 2 1588.51 936.34 586.13 349.76 546.94 482.78
Replicate 2 Call P P P P P P
Replicate 3 1530.09 901.87 223.89 596.51 404.26 426.64
Replicate 3 Call P P P P P P
Mean 1537.46 883.69 501.83 415.33 431.84 428.01
Standard Deviation 47.8 63.72 246.83 158.89 104.08 54.09
Log2 Mean 10.59 9.78 8.81 8.63 8.73 8.73
Log2 Standard Deviation 0.04 0.11 0.88 0.52 0.34 0.18
Probe set ID: 1425987_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 178.41 224.63 241.46 237.09 221.85 287.18
Replicate 1 Call A A P A A A
Replicate 2 198.67 244.78 234.15 256.3 277.65 338.8
Replicate 2 Call A A A A A A
Replicate 3 169.7 194.59 259.47 295.64 212.13 290.44
Replicate 3 Call A A P A A A
Replicate 4 357.56 264.27 220.33 278.06
Replicate 4 Call P A A A
Mean 182.26 221.33 273.16 263.33 232.99 298.62
Standard Deviation 14.86 25.26 57.26 24.38 30.08 27.29
Log2 Mean 7.51 7.78 8.07 8.04 7.86 8.22
Log2 Standard Deviation 0.12 0.17 0.28 0.13 0.18 0.13
 
Vestibular ganglion
Replicate 1 184.36 234.23 287.72 254.87 186.68 189.32
Replicate 1 Call A P A A A A
Replicate 2 242.67 224.81 192.12 211.39 195.72 184.59
Replicate 2 Call A P A A A P
Replicate 3 196.73 240.92 206.66 221.41 238.28 192.5
Replicate 3 Call A P A A A P
Mean 207.92 233.32 228.83 229.22 206.89 188.8
Standard Deviation 30.72 8.09 51.51 22.77 27.55 3.98
Log2 Mean 7.69 7.87 7.82 7.84 7.68 7.56
Log2 Standard Deviation 0.21 0.05 0.31 0.14 0.19 0.03
Probe set ID: 1428948_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 140.11 276.4 310.46 319.13 1649.95 745.02
Replicate 1 Call P P P P P P
Replicate 2 121.24 274.55 283.45 365.67 843.57 845.58
Replicate 2 Call P P P P P P
Replicate 3 152.95 295.9 339.26 286.83 2539.74 906.81
Replicate 3 Call P P P P P P
Replicate 4 202.51 288.04 2500.21 719.67
Replicate 4 Call P P P P
Mean 138.1 282.28 283.92 314.92 1883.37 804.27
Standard Deviation 15.95 11.83 58.86 36.99 805.6 87.35
Log2 Mean 7.1 8.14 8.12 8.29 10.75 9.65
Log2 Standard Deviation 0.17 0.06 0.33 0.16 0.75 0.16
 
Vestibular ganglion
Replicate 1 335.76 363 389.93 582.98 505.36 345.29
Replicate 1 Call P P P P P P
Replicate 2 310.64 404.44 378.86 356.77 1048.55 267.81
Replicate 2 Call P P P P P P
Replicate 3 307.69 351.11 460.87 461.25 930.88 291.45
Replicate 3 Call P P P P P P
Mean 318.03 372.85 409.89 467 828.26 301.52
Standard Deviation 15.43 28 44.5 113.21 285.76 39.71
Log2 Mean 8.31 8.54 8.67 8.84 9.63 8.23
Log2 Standard Deviation 0.07 0.11 0.15 0.35 0.56 0.19