GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description homeobox A2
Synonyms Hox-1.11
Chromosome 6
Genetic Map Distance 25.40 cM
RefSeq Accessions NM_010451; NP_034581
NCBI Entrez Gene 15399 at chr6:52112510-52114830 (mm9) / chr6:52162417-52164831 (mm10)
Ensembl Gene ENSMUSG00000014704
VEGA Gene OTTMUSG00000037358
MGI Gene MGI:96174
Mouse Protein (10)
UniProt ID Description Length (AA) Predicted # TMs
P31245 Homeobox protein Hox-A2 372 0
Q3UYP9 Putative uncharacterized protein (Fragment) 317 0
Q920T7 Homeobox protein (Fragment) 246 0
Q920T9 Homeobox protein (Fragment) 246 0
Q920U0 Homeobox protein (Fragment) 246 0
Q920U1 Homeobox protein (Fragment) 246 0
Q920U2 Homeobox protein (Fragment) 246 0
Q920U3 Homeobox protein (Fragment) 246 0
Q920U4 Homeobox protein (Fragment) 246 0
Q920U5 Homeobox protein (Fragment) 246 0
Pfam Domains Pfam-B_13599; Homeobox
Mouse alleles (13)
Allele Name Allele Type
Hoxa2tm1a(EUCOMM)Wtsi EUCOMM-projects
Hoxa2tm1e(EUCOMM)Wtsi EUCOMM-projects
Hoxa2tm1(KOMP)Vlcg KOMP-Regeneron-Project
Hoxa2tm1(tetO)Mllo Targeted (knock-in)
Hoxa2tm1.1Fmr Targeted (Floxed/Frt)
Hoxa2tm1.2Fmr Targeted (knock-out)
Hoxa2tm1Fmr Targeted (Floxed/Frt)
Hoxa2tm1Grid Targeted (knock-out)
Hoxa2tm1Ipc Targeted (knock-out)
Hoxa2tm1Mrc Targeted (knock-out)
Hoxa2tm2(cre)Mrc Targeted (knock-in)
Hoxa2tm2.1Fmr Targeted (Reporter)
Hoxa2tm2Fmr Targeted (knock-out)
Human Homolog HOXA2 (homeobox A2)
Human synonyms HOX1K
Human cytoband 7p15.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (0)
Gene Ontology
Biological Process (28) transcription; DNA-dependent; cell fate determination; middle ear morphogenesis; middle ear morphogenesis; embryonic viscerocranium morphogenesis; regulation of transcription; DNA-dependent; regulation of transcription; DNA-dependent; cell fate commitment; anterior/posterior pattern specification; brain segmentation; osteoblast development; negative regulation of transcription from RNA polymerase II promoter; embryonic skeletal system morphogenesis; middle ear morphogenesis; cell fate commitment; rhombomere 3 morphogenesis; dorsal/ventral pattern formation; dorsal/ventral pattern formation; rhombomere 2 development; rhombomere 3 development; negative regulation of neuron differentiation; negative regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; multicellular organismal development; pattern specification process; segment specification; motor axon guidance; pattern specification process
Cellular Component (3) nucleus; nucleus; nucleus
Molecular Function (4) sequence-specific DNA binding; DNA binding; DNA binding; sequence-specific DNA binding transcription factor activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
13
1
3
0
0
45
Cochlea GFP+ cells
1
10
0
2
17
NA
Utricle GFP- cells
25
18
34
5
6
0
Cochlea GFP- cells
66
75
16
25
21
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
26
GFP+
8
0.33
0.239
Utricle
12
Cochlea
23
1.85
1
Embryonic
26
Postnatal
12
0.48
0.742
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17466805 6.18 ± 0.52 6.78 ± 0.68 [8.29] 1.10 0.541
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
50
53
26
83
No bFGF
68
68
65
57
EGF
29
32
22
28
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
83
No bFGF
57
0.69
1
bFGF
83
EGF
28
0.34
2.47e-8
No bFGF
57
EGF
28
0.49
0.00138
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Hoxa2.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1419602_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 163.99 414.52 9.95 46.77 307.22 669.31
Replicate 1 Call P P A A P P
Replicate 2 189.53 329.84 24 98.61 173.17 340.74
Replicate 2 Call P P P P P P
Replicate 3 170.43 303.59 13.64 19.14 568.02 429.37
Replicate 3 Call P P A A P P
Replicate 4 17.94 14.3 627.74 706.15
Replicate 4 Call A A P P
Mean 174.65 349.32 16.38 44.71 419.04 536.39
Standard Deviation 13.28 57.97 6.04 38.68 215.02 179.09
Log2 Mean 7.45 8.44 3.96 5.07 8.54 9
Log2 Standard Deviation 0.11 0.23 0.54 1.27 0.86 0.51
 
Vestibular ganglion
Replicate 1 321.32 408.91 86.59 283.64 63.13 49.34
Replicate 1 Call P P A P A P
Replicate 2 312.81 439.09 572.29 40.55 139.11 34.9
Replicate 2 Call P P P A P A
Replicate 3 295.59 334.88 764.71 969.57 353.96 41.54
Replicate 3 Call P P P P P A
Mean 309.91 394.29 474.53 431.25 185.4 41.93
Standard Deviation 13.11 53.62 349.47 481.78 150.84 7.23
Log2 Mean 8.27 8.61 8.39 7.8 7.19 5.38
Log2 Standard Deviation 0.06 0.2 1.71 2.31 1.25 0.25