GENE VIEW

Hgf

MOUSE GENE INFORMATION [PubMed]
Description hepatocyte growth factor
Synonyms SF/HGF; scatter factor; C230052L06Rik; HGF/SF; NK2; NK1
Chromosome 5
Genetic Map Distance 7.07 cM
RefSeq Accessions NP_034557; XM_131908
NCBI Entrez Gene 15234 at chr5:16059368-16125257 (mm9) / chr5:16553331-16622450 (mm10)
Ensembl Gene ENSMUSG00000028864
VEGA Gene
MGI Gene MGI:96079
Mouse Protein (5)
UniProt ID Description Length (AA) Predicted # TMs
Q08048 Hepatocyte growth factor 728 1
O55027 Hepatocyte growth factor NK1 211 1
Q53WS5 Hepatocyte growth factor/scatter factor 728 1
Q8C4E2 Putative uncharacterized protein 162 1
Q8C9G5 Putative uncharacterized protein 728 1
Pfam Domains PAN_1; Kringle; Kringle; Kringle; Kringle; Trypsin
Mouse alleles (4)
Allele Name Allele Type
Hgftm1.1(HGF)Aveo Targeted (knock-in)
Hgftm1Cbm Targeted (knock-out)
Hgftm1Jmw Targeted (Floxed/Frt)
Hgftm1Kita Targeted (knock-out)
Human Homolog HGF (hepatocyte growth factor (hepapoietin A; scatter factor))
Human synonyms DFNB39; F-TCF; HGFB; HPTA; SF
Human cytoband 7q21.1
Known deafness gene DFNB39
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (4)
ENSGALG00000008461 (Q788Q2_CHICK) encoding ENSGALP00000013774
ENSGALG00000008461 (Q788Q2_CHICK) encoding ENSGALP00000038996
ENSGALG00000008461 (Q788Q2_CHICK) encoding ENSGALP00000038999
ENSGALG00000008461 (Q788Q2_CHICK) encoding ENSGALP00000039002
Gene Ontology
Biological Process (17) proteolysis; anti-apoptosis; activation of MAPK activity; hepatocyte growth factor receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; cell morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; myoblast proliferation; cell chemotaxis; negative regulation of apoptotic process; liver development; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; cell proliferation; cell proliferation; cellular response to hepatocyte growth factor stimulus; positive regulation of DNA biosynthetic process
Cellular Component (1) extracellular space
Molecular Function (4) protein heterodimerization activity; catalytic activity; serine-type endopeptidase activity; growth factor activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
0
0
0
2
0
6
Cochlea GFP+ cells
1
10
18
0
0
NA
Utricle GFP- cells
19
8
1
0
0
0
Cochlea GFP- cells
3
13
2
0
1
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
4
GFP+
3
0.81
0.926
Utricle
3
Cochlea
5
1.66
1
Embryonic
7
Postnatal
2
0.33
0.509
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17434933 6.07 ± 0.06 6.03 ± 0.57 [7.30] 0.99 0.883
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
0
0
15
No bFGF
0
0
1
0
EGF
0
0
0
0
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
15
No bFGF
0
0.06
0.0016
bFGF
15
EGF
0
0.02
1.99e-10
No bFGF
0
EGF
0
0.33
0.732
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1425379_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 8.37 2.79 6.25 1 12.81 11.95
Replicate 1 Call A A A A A A
Replicate 2 6.85 2.89 1 8.02 4.67 30.92
Replicate 2 Call A P A A A A
Replicate 3 26.53 1 1.96 10.66 16.61 1.69
Replicate 3 Call A A A A A A
Replicate 4 1.59 1 1.11 25.5
Replicate 4 Call A A A A
Mean 13.92 2.23 2.7 5.17 8.8 17.52
Standard Deviation 10.95 1.06 2.4 4.93 7.15 13.23
Log2 Mean 3.52 1 1.07 1.6 2.53 3.49
Log2 Standard Deviation 1.05 0.87 1.12 1.86 1.77 1.92
 
Vestibular ganglion
Replicate 1 4.45 1 12.07 10.71 10.82 6.58
Replicate 1 Call A A A A A P
Replicate 2 2.15 1.91 1.32 25.67 16.15 1.8
Replicate 2 Call A P A A A A
Replicate 3 3.64 1.08 1 1.34 3.69 6.72
Replicate 3 Call A A A A A P
Mean 3.41 1.33 4.8 12.57 10.22 5.03
Standard Deviation 1.17 0.5 6.3 12.27 6.25 2.8
Log2 Mean 1.71 0.35 1.33 2.84 3.11 2.1
Log2 Standard Deviation 0.54 0.51 1.97 2.19 1.1 1.09
Probe set ID: 1451866_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 98.72 139.68 129.3 138.16 80.29 74.92
Replicate 1 Call A P A M A A
Replicate 2 127.87 110.87 131.38 133.84 106.64 109.89
Replicate 2 Call A A A A A A
Replicate 3 114.25 152.31 99.61 98.68 87.54 83.02
Replicate 3 Call A P A A A A
Replicate 4 123.01 120.36 66.96 119.07
Replicate 4 Call P A A A
Mean 113.61 134.29 120.83 122.76 85.36 96.73
Standard Deviation 14.59 21.24 14.58 17.75 16.55 21.1
Log2 Mean 6.82 7.06 6.91 6.93 6.4 6.57
Log2 Standard Deviation 0.19 0.24 0.18 0.22 0.28 0.32
 
Vestibular ganglion
Replicate 1 103.43 76.1 57.73 68.26 93.32 101.41
Replicate 1 Call A A A A A A
Replicate 2 110.16 101.21 81.77 103.64 100.6 86.14
Replicate 2 Call A A A A A A
Replicate 3 124.99 73.15 106.38 77.58 62.89 73.7
Replicate 3 Call A A A A A A
Mean 112.86 83.49 81.96 83.16 85.6 87.08
Standard Deviation 11.03 15.42 24.33 18.34 20 13.88
Log2 Mean 6.81 6.37 6.31 6.36 6.39 6.43
Log2 Standard Deviation 0.14 0.26 0.44 0.31 0.36 0.23