GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms LGN; 6230410J09Rik; Pins
Chromosome 3
Genetic Map Distance 47.53 cM
RefSeq Accessions NM_029522; NP_083798
NCBI Entrez Gene 76123 at chr3:108481556-108525217 (mm9) / chr3:108678638-108722333 (mm10)
Ensembl Gene ENSMUSG00000027883
VEGA Gene OTTMUSG00000007258
MGI Gene MGI:1923373
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q8VDU0 G-protein-signaling modulator 2 679 0
A2AEL5 G-protein signalling modulator 2 (AGS3-like, C. elegans) (Fragment) 154 0
Q3UPG3 G-protein signalling modulator 2 (AGS3-like, C. elegans) 679 0
Pfam Domains TPR_1; TPR_1; TPR_1; Pfam-B_1429; TPR_1; Pfam-B_11259; TPR_1; TPR_1; TPR_1; GoLoco; GoLoco; GoLoco; GoLoco
Mouse alleles (3)
Allele Name Allele Type
Gpsm2tm1a(EUCOMM)Wtsi EUCOMM-projects
Gpsm2tm1.1(Venus)Fuma Targeted (Reporter)
Gpsm2tm1.2Fuma Targeted (knock-out)
Human Homolog GPSM2 (G-protein signaling modulator 2)
Human synonyms DFNB82; LGN; PINS
Human cytoband 1p13.3
Known deafness gene DFNB32 /DFNB82
Within mapped deafness loci WS2B
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000002090 (GPSM2) encoding ENSGALP00000003253
Gene Ontology
Biological Process (5) regulation of G-protein coupled receptor protein signaling pathway; signal transduction; regulation of catalytic activity; establishment of mitotic spindle orientation; lung epithelial cell differentiation
Cellular Component (4) apical part of cell; nucleus; cytoplasm; cell
Molecular Function (4) GTPase regulator activity; identical protein binding; GDP-dissociation inhibitor activity; binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
182
329
603
274
256
84
Cochlea GFP+ cells
82
167
391
308
427
NA
Utricle GFP- cells
125
148
112
68
86
47
Cochlea GFP- cells
120
102
73
127
84
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
99
GFP+
282
2.83
0.22
Utricle
193
Cochlea
188
0.98
1
Embryonic
157
Postnatal
210
1.34
0.942
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17409386 215.95 ± 10.01 170.48 ± 22.36 [137.52] 0.79 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1224
1116
1013
1430
No bFGF
873
843
716
801
EGF
1152
1029
938
1040
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1430
No bFGF
801
0.56
0.356
bFGF
1430
EGF
1040
0.73
0.00311
No bFGF
801
EGF
1040
1.30
0.0305
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1424895_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1860.6 1945.31 538.18 744.14 998.27 964.9
Replicate 1 Call P P P M P P
Replicate 2 1896.05 2173.77 427.38 1011.06 823.65 1408.16
Replicate 2 Call P P A P P P
Replicate 3 1992.95 2322.05 524.52 244.34 1680.13 658.11
Replicate 3 Call P P P A P P
Replicate 4 459.21 263.29 1557.15 497.34
Replicate 4 Call A A P M
Mean 1916.53 2147.04 487.32 565.71 1264.8 882.13
Standard Deviation 68.51 189.79 52.77 376.35 417.78 400.75
Log2 Mean 10.9 11.06 8.92 8.87 10.24 9.67
Log2 Standard Deviation 0.05 0.13 0.16 1.04 0.5 0.65
 
Vestibular ganglion
Replicate 1 1836.37 2246.68 2445.8 1910.69 1604.99 896.32
Replicate 1 Call P P P P P P
Replicate 2 1795.35 2331.34 2438.73 1725.95 2181.95 895.85
Replicate 2 Call P P P P P P
Replicate 3 1844.16 2247.17 2385.7 1555.59 1977.39 1030.83
Replicate 3 Call P P P P P P
Mean 1825.29 2275.06 2423.41 1730.74 1921.44 941
Standard Deviation 26.22 48.74 32.85 177.6 292.52 77.8
Log2 Mean 10.83 11.15 11.24 10.75 10.9 9.87
Log2 Standard Deviation 0.02 0.03 0.02 0.15 0.23 0.12
Probe set ID: 1436730_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 131.46 182.56 133.48 80.54 90.22 78.74
Replicate 1 Call A P P A A A
Replicate 2 131.39 179.56 141.83 113.53 96.62 128.71
Replicate 2 Call A P A A A A
Replicate 3 169.23 214.1 92.57 64.57 116.75 102.14
Replicate 3 Call A P P A A A
Replicate 4 193.04 68.63 64.73 175.23
Replicate 4 Call P A A P
Mean 144.03 192.07 140.23 81.82 92.08 121.21
Standard Deviation 21.83 19.13 41.27 22.2 21.45 41.4
Log2 Mean 7.16 7.58 7.08 6.32 6.49 6.86
Log2 Standard Deviation 0.21 0.14 0.43 0.36 0.35 0.49
 
Vestibular ganglion
Replicate 1 126.11 147.11 91.29 107.34 64.61 156.41
Replicate 1 Call A A A A A A
Replicate 2 119.8 137.76 110.4 80.76 114.36 135.25
Replicate 2 Call A P A A A P
Replicate 3 117.76 144.4 117.03 68.29 101.38 141.95
Replicate 3 Call A P A A A A
Mean 121.22 143.09 106.24 85.46 93.45 144.54
Standard Deviation 4.35 4.81 13.36 19.95 25.81 10.81
Log2 Mean 6.92 7.16 6.72 6.39 6.5 7.17
Log2 Standard Deviation 0.05 0.05 0.19 0.33 0.43 0.11