GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description gap junction protein, beta 2
Synonyms Gjb-2; connexin 26; Cx26
Chromosome 14
Genetic Map Distance 30.10 cM
RefSeq Accessions NM_008125; NP_032151
NCBI Entrez Gene 14619 at chr14:57717439-57723539 (mm9) / chr14:57098602-57104702 (mm10)
Ensembl Gene ENSMUSG00000046352
VEGA Gene OTTMUSG00000034674
MGI Gene MGI:95720
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
Q00977 Gap junction beta-2 protein 226 4
Q3TZE5 Putative uncharacterized protein 226 4
Q3UJE9 Gap junction membrane channel protein beta 2, isoform CRA_a 226 4
Q3UY12 Putative uncharacterized protein 226 4
Pfam Domains Connexin; COX6A; Connexin_CCC
Mouse alleles (9)
Allele Name Allele Type
Gjb2tm1(KOMP)Vlcg KOMP-Regeneron-Project
Gjb2E119stop Chemically induced (ENU)
Gjb2I128V Chemically induced (ENU)
Gjb2K102N Chemically induced (ENU)
Gjb2tm1Kwi Targeted (knock-out)
Gjb2tm1Mony Targeted (Reporter)
Gjb2tm1Ugds Targeted (Floxed/Frt)
Gjb2tm2.1Kwi Targeted (Floxed/Frt)
Gjb2tm2.2Kwi Targeted (Reporter)
Human Homolog GJB2 (gap junction protein, beta 2, 26kDa)
Human synonyms CX26; DFNA3; DFNA3A; DFNB1; DFNB1A; HID; KID; NSRD1; PPK
Human cytoband 13q11-q12
Known deafness gene DFNB1A/DFNA3A
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (0)
Gene Ontology
Biological Process (2) cell communication; sensory perception of sound
Cellular Component (8) plasma membrane; connexon complex; lateral plasma membrane; gap junction; gap junction; integral to membrane; membrane; cell junction
Molecular Function (1) protein binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
412
1215
124
276
607
91
Cochlea GFP+ cells
911
6946
872
1840
1033
NA
Utricle GFP- cells
1068
1488
3486
9138
16219
5066
Cochlea GFP- cells
1675
637
665
1893
5030
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
4215
GFP+
1302
0.31
0.45
Utricle
3266
Cochlea
2150
0.66
1
Embryonic
1794
Postnatal
3310
1.85
0.866
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17307117 1054.46 ± 30.76 582.29 ± 116.78 [707.66] 0.55 0.374
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
2
0
0
No bFGF
0
0
0
0
EGF
0
1
0
0
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
0
No bFGF
0
0.00
1
bFGF
0
EGF
0
1.68
1
No bFGF
0
EGF
0
0.00
0.282
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Gjb2.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1423271_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 155.86 181.47 148.36 857.4 5412.29 7432.03
Replicate 1 Call P P A P P P
Replicate 2 183.3 179.55 253.79 2416.92 1565.55 5177.14
Replicate 2 Call P P P P P P
Replicate 3 226.79 179.43 224.15 515.29 6038.39 3152.02
Replicate 3 Call P P A P P P
Replicate 4 460.18 190.2 5927.86 3590.53
Replicate 4 Call P A P P
Mean 188.65 180.15 271.62 994.95 4736.02 4837.93
Standard Deviation 35.77 1.14 133.32 986.34 2131.19 1935.86
Log2 Mean 7.54 7.49 7.96 9.39 12.03 12.16
Log2 Standard Deviation 0.27 0.01 0.67 1.53 0.95 0.56
 
Vestibular ganglion
Replicate 1 219.39 278.15 5128.42 3862.48 4344.37 4774.19
Replicate 1 Call P P P P P P
Replicate 2 233.42 297.86 4441.63 4985.26 5018.75 4076.42
Replicate 2 Call P P P P P P
Replicate 3 197.6 311.84 3745.96 3228 5209.54 4699.9
Replicate 3 Call P P P P P P
Mean 216.8 295.95 4438.67 4025.25 4857.55 4516.84
Standard Deviation 18.05 16.93 691.23 889.87 454.55 383.22
Log2 Mean 7.76 8.21 12.1 11.95 12.24 12.14
Log2 Standard Deviation 0.12 0.08 0.23 0.32 0.14 0.13