MOUSE GENE INFORMATION [PubMed]
| Description | GIPC PDZ domain containing family, member 3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Synonyms | Ahl5; Gipc3; Rgs19ip3 | ||||||||||
| Chromosome | 10 | ||||||||||
| Genetic Map Distance | 39.72 cM | ||||||||||
| RefSeq Accessions | NM_148951; NP_683753 | ||||||||||
| NCBI Entrez Gene | 209047 at chr10:80800507-80806011 (mm9) / chr10:81336526-81343612 (mm10) | ||||||||||
| Ensembl Gene | ENSMUSG00000034872 | ||||||||||
| VEGA Gene | OTTMUSG00000027857 | ||||||||||
| MGI Gene | MGI:2387006 | ||||||||||
| Mouse Protein (1) |
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| Pfam Domains | Pfam-B_3689; PDZ; CBM_X | ||||||||||
| Mouse alleles (4) |
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| Human Homolog | GIPC3 (GIPC PDZ domain containing family, member 3) | ||||||||||
| Human synonyms | C19orf64; DFNB15; DFNB72; DFNB95 | ||||||||||
| Human cytoband | 19p13.3 | ||||||||||
| Known deafness gene | DFNB15/DFNB95 | ||||||||||
| Within mapped deafness loci | DFNB72 | ||||||||||
| Associated Human Disease in OMIM |
None
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| Chicken homolog (0) |
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Gene Ontology
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FACS-Sorted Hair Cells
Data |
Chart
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
|
|---|---|---|---|---|---|---|
Utricle GFP+ cells |
0 |
0 |
0 |
0 |
0 |
0 |
Cochlea GFP+ cells |
0 |
0 |
0 |
0 |
0 |
NA |
Utricle GFP- cells |
0 |
0 |
0 |
0 |
0 |
0 |
Cochlea GFP- cells |
0 |
1 |
0 |
0 |
0 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
GFP- |
0 |
GFP+ |
0 |
0.29 |
0.945 |
Utricle |
0 |
Cochlea |
0 |
4.10 |
1 |
Embryonic |
0 |
Postnatal |
0 |
0.25 |
1 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID | IHC (mean ± sd) | OHC (mean ± sd) [OHC replicate] | Fold Change (OHC/IHC) | False Discovery Rate (FDR) |
|---|---|---|---|---|
| 17243278 | 34.37 ± 7.52 | 65.90 ± 23.14 [59.10] | 1.92 | 0.501 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
|---|---|---|---|---|
bFGF |
0 |
2 |
1 |
3 |
No bFGF |
0 |
5 |
3 |
2 |
EGF |
0 |
0 |
0 |
0 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
bFGF |
3 |
No bFGF |
2 |
0.71 |
1 |
bFGF |
3 |
EGF |
0 |
0.09 |
0.0217 |
No bFGF |
2 |
EGF |
0 |
0.12 |
0.107 |
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Gipc3.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1426150_at
| Age | E12 | E13 | E16 | P0 | P6 | P15 |
|---|---|---|---|---|---|---|
| Spiral ganglion | ||||||
| Replicate 1 | 17.6 | 57.23 | 24 | 23.38 | 22.85 | 33.08 |
| Replicate 1 Call | A | A | A | A | A | A |
| Replicate 2 | 27.25 | 38.1 | 43.39 | 40.84 | 36.47 | 23.35 |
| Replicate 2 Call | A | A | A | A | A | A |
| Replicate 3 | 28.08 | 43.48 | 16.84 | 26 | 39.54 | 49.43 |
| Replicate 3 Call | A | A | A | A | A | A |
| Replicate 4 | 8.8 | 32.63 | 37.12 | 30.47 | ||
| Replicate 4 Call | A | A | A | A | ||
| Mean | 24.31 | 46.27 | 23.26 | 30.71 | 34 | 34.08 |
| Standard Deviation | 5.83 | 9.87 | 14.79 | 7.79 | 7.55 | 11.03 |
| Log2 Mean | 4.57 | 5.51 | 4.31 | 4.91 | 5.06 | 5.04 |
| Log2 Standard Deviation | 0.38 | 0.3 | 0.96 | 0.36 | 0.36 | 0.45 |
| Vestibular ganglion | ||||||
| Replicate 1 | 7.8 | 44.9 | 32.19 | 44.63 | 28.48 | 34.6 |
| Replicate 1 Call | A | A | A | A | A | A |
| Replicate 2 | 30.39 | 44.28 | 49.11 | 27.59 | 38.69 | 40.37 |
| Replicate 2 Call | A | A | A | A | A | A |
| Replicate 3 | 14.15 | 57.5 | 28.01 | 20.97 | 27.96 | 32.36 |
| Replicate 3 Call | A | A | A | A | A | A |
| Mean | 17.45 | 48.89 | 36.44 | 31.06 | 31.71 | 35.78 |
| Standard Deviation | 11.65 | 7.46 | 11.17 | 12.21 | 6.05 | 4.13 |
| Log2 Mean | 3.9 | 5.6 | 5.14 | 4.89 | 4.97 | 5.15 |
| Log2 Standard Deviation | 0.98 | 0.21 | 0.42 | 0.55 | 0.26 | 0.16 |