MOUSE GENE INFORMATION [PubMed]
| Description | growth differentiation factor 15 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Synonyms | MIC-1; macrophage inhibiting cytokine-1; NAG-1 | ||||||||||||||||||||
| Chromosome | 8 | ||||||||||||||||||||
| Genetic Map Distance | 34.15 cM | ||||||||||||||||||||
| RefSeq Accessions | NM_011819; NP_035949 | ||||||||||||||||||||
| NCBI Entrez Gene | 23886 at chr8:73153293-73155534 (mm9) / chr8:70629393-70632605 (mm10) | ||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000038508 | ||||||||||||||||||||
| VEGA Gene | OTTMUSG00000023705 | ||||||||||||||||||||
| MGI Gene | MGI:1346047 | ||||||||||||||||||||
| Mouse Protein (4) |
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| Pfam Domains | TGF_beta | ||||||||||||||||||||
| Mouse alleles (4) |
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| Human Homolog | GDF15 (growth differentiation factor 15) | ||||||||||||||||||||
| Human synonyms | GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB | ||||||||||||||||||||
| Human cytoband | 19p13.11 | ||||||||||||||||||||
| Known deafness gene | No | ||||||||||||||||||||
| Within mapped deafness loci | No | ||||||||||||||||||||
| Associated Human Disease in OMIM |
None
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| Chicken homolog (0) |
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Gene Ontology
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FACS-Sorted Hair Cells
Data |
Chart
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
|
|---|---|---|---|---|---|---|
Utricle GFP+ cells |
0 |
1 |
0 |
0 |
0 |
0 |
Cochlea GFP+ cells |
0 |
2 |
0 |
0 |
0 |
NA |
Utricle GFP- cells |
0 |
4 |
1 |
0 |
1 |
0 |
Cochlea GFP- cells |
0 |
0 |
4 |
2 |
1 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
GFP- |
1 |
GFP+ |
0 |
0.28 |
0.699 |
Utricle |
0 |
Cochlea |
1 |
1.44 |
1 |
Embryonic |
1 |
Postnatal |
0 |
0.62 |
0.995 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID | IHC (mean ± sd) | OHC (mean ± sd) [OHC replicate] | Fold Change (OHC/IHC) | False Discovery Rate (FDR) |
|---|---|---|---|---|
| 17510114 | 9.02 ± 0.00 | 8.69 ± 0.43 [9.02] | 0.96 | 0.615 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
|---|---|---|---|---|
bFGF |
5 |
8 |
8 |
6 |
No bFGF |
0 |
9 |
11 |
6 |
EGF |
0 |
1 |
6 |
2 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
bFGF |
6 |
No bFGF |
6 |
0.97 |
1 |
bFGF |
6 |
EGF |
2 |
0.43 |
0.0958 |
No bFGF |
6 |
EGF |
2 |
0.44 |
0.128 |
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Gdf15.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1418949_at
| Age | E12 | E13 | E16 | P0 | P6 | P15 |
|---|---|---|---|---|---|---|
| Spiral ganglion | ||||||
| Replicate 1 | 4.03 | 22.81 | 12.09 | 35.39 | 21.27 | 106.81 |
| Replicate 1 Call | A | A | A | A | A | A |
| Replicate 2 | 1 | 1.23 | 30.54 | 43.49 | 32.46 | 92.68 |
| Replicate 2 Call | A | A | A | A | A | A |
| Replicate 3 | 32.82 | 14.39 | 10.88 | 25.06 | 22.29 | 56.8 |
| Replicate 3 Call | A | A | A | A | A | A |
| Replicate 4 | 3 | 18.37 | 25.31 | 43.22 | ||
| Replicate 4 Call | A | A | A | A | ||
| Mean | 12.62 | 12.81 | 14.13 | 30.58 | 25.33 | 74.88 |
| Standard Deviation | 17.56 | 10.88 | 11.66 | 11.1 | 5.05 | 29.81 |
| Log2 Mean | 2.35 | 2.89 | 3.39 | 4.86 | 4.64 | 6.13 |
| Log2 Standard Deviation | 2.54 | 2.26 | 1.38 | 0.55 | 0.27 | 0.61 |
| Vestibular ganglion | ||||||
| Replicate 1 | 12.46 | 16.54 | 24.37 | 21.59 | 16.55 | 8.08 |
| Replicate 1 Call | A | A | A | A | A | A |
| Replicate 2 | 24.18 | 19.69 | 22.72 | 16.53 | 26.29 | 28.31 |
| Replicate 2 Call | A | A | A | A | A | A |
| Replicate 3 | 14.74 | 19.4 | 15.1 | 17.48 | 38.99 | 18.25 |
| Replicate 3 Call | A | A | A | A | A | A |
| Mean | 17.13 | 18.54 | 20.73 | 18.53 | 27.28 | 18.21 |
| Standard Deviation | 6.21 | 1.74 | 4.95 | 2.69 | 11.25 | 10.12 |
| Log2 Mean | 4.04 | 4.21 | 4.34 | 4.2 | 4.68 | 4.01 |
| Log2 Standard Deviation | 0.5 | 0.14 | 0.37 | 0.2 | 0.62 | 0.92 |