MOUSE GENE INFORMATION [
PubMed]
| Description |
GATA binding protein 3 |
| Synonyms |
jal; Gata-3 |
| Chromosome |
2 |
| Genetic Map Distance |
6.69 cM |
| RefSeq Accessions |
NM_008091; NP_032117 |
| NCBI Entrez Gene |
14462 at
chr2:9778705-9800227 (mm9)
/
chr2:9857078-9887669 (mm10)
|
| Ensembl Gene |
ENSMUSG00000015619
|
| VEGA Gene |
OTTMUSG00000011129
|
| MGI Gene |
MGI:95663
|
| Mouse Protein (6) |
| UniProt ID |
Description |
Length (AA) |
Predicted # TMs |
|
P23772
|
Trans-acting T-cell-specific transcription factor GATA-3
|
443 |
0 |
|
A2AS31
|
GATA binding protein 3 (Fragment)
|
119 |
0 |
|
Q3TZD6
|
Putative uncharacterized protein
|
365 |
0 |
|
Q3TZS0
|
Putative uncharacterized protein
|
408 |
0 |
|
Q3U0R5
|
GATA binding protein 3
|
443 |
0 |
|
Q3U223
|
Putative uncharacterized protein
|
442 |
0 |
|
| Pfam Domains |
GATA; GATA |
| Mouse alleles (12) |
|
| Human Homolog |
GATA3
(GATA binding protein 3)
|
| Human synonyms |
HDR; HDRS
|
| Human cytoband |
10p15 |
| Known deafness gene |
* |
| Within mapped deafness loci |
No
|
| Associated Human Disease in OMIM |
|
| Chicken homolog (1) |
ENSGALG00000006726 (GATA3_CHICK) encoding ENSGALP00000010868
|
|
Gene Ontology
|
| Biological Process
(130) |
positive regulation of transcription from RNA polymerase II promoter; T-helper 2 cell differentiation; signal transduction; neuron differentiation; nervous system development; in utero embryonic development; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; canonical Wnt receptor signaling pathway involved in metanephric kidney development; male gonad development; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; positive regulation of T cell differentiation; negative regulation of cell proliferation involved in mesonephros development; positive regulation of cell differentiation; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; negative regulation of cell proliferation; negative regulation of cell cycle; negative regulation of cell cycle; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; T cell differentiation; positive regulation of transcription from RNA polymerase II promoter; T cell differentiation; erythrocyte differentiation; cell morphogenesis; transcription; DNA-dependent; axon guidance; negative regulation of transcription from RNA polymerase II promoter; positive regulation of signal transduction; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; inner ear morphogenesis; negative regulation of transcription; DNA-dependent; thymic T cell selection; negative regulation of cell proliferation; humoral immune response; regulation of transcription; DNA-dependent; regulation of cytokine biosynthetic process; inner ear morphogenesis; regulation of transcription from RNA polymerase II promoter; cell fate determination; norepinephrine biosynthetic process; positive regulation of transcription; DNA-dependent; positive regulation of transcription; DNA-dependent; positive regulation of transcription; DNA-dependent; positive regulation of transcription; DNA-dependent; positive regulation of transcription; DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; uterus development; pharyngeal system development; regulation of histone H3-K4 methylation; ventricular septum development; ureteric bud formation; regulation of neuron apoptosis; positive regulation of endothelial cell migration; parathyroid gland development; negative regulation of mammary gland epithelial cell proliferation; lens development in camera-type eye; mesenchymal to epithelial transition; mesonephros development; developmental growth; anatomical structure formation involved in morphogenesis; otic vesicle development; embryonic hemopoiesis; renal system development; regulation of CD4-positive; alpha-beta T cell differentiation; regulation of histone H3-K27 methylation; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; cellular response to cytokine stimulus; lymphocyte migration; negative regulation of cell motility; T cell differentiation in thymus; negative regulation of endothelial cell apoptosis; T cell differentiation in thymus; positive regulation of thyroid hormone generation; T cell differentiation in thymus; positive regulation of interleukin-5 secretion; T cell differentiation in thymus; positive regulation of interleukin-13 secretion; mast cell differentiation; regulation of cellular response to X-ray; cellular response to interleukin-4; ne |
| Cellular Component
(11) |
intracellular; cell; cell; nucleolus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nuclear chromatin |
| Molecular Function
(34) |
DNA binding; core promoter sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; HMG box domain binding; nucleic acid binding transcription factor activity; nucleic acid binding transcription factor activity; transcription coactivator activity; transcription coactivator activity; transcription coactivator activity; protein binding; sequence-specific DNA binding transcription factor activity; protein binding; protein binding; transcription factor binding; zinc ion binding; interleukin-2 receptor binding; core promoter proximal region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding; protein dimerization activity; E-box binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription regulatory region DNA binding; transcription regulatory region DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; nucleic acid binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; enhancer sequence-specific DNA binding; enhancer sequence-specific DNA binding; metal ion binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding |
|
FACS-Sorted Hair Cells
|
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
Utricle GFP+ cells |
741 |
1263 |
2691 |
528 |
99 |
856 |
Cochlea GFP+ cells |
4913 |
16485 |
13443 |
27434 |
24988 |
NA |
Utricle GFP- cells |
1192 |
565 |
737 |
191 |
176 |
3791 |
Cochlea GFP- cells |
4383 |
2938 |
2448 |
2196 |
4817 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
GFP- |
2130 |
GFP+ |
8495 |
3.99 |
0.00913 |
Utricle |
1069 |
Cochlea |
10405 |
9.73 |
0.0147 |
Embryonic |
4060 |
Postnatal |
6028 |
1.48 |
0.929 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID |
IHC (mean ± sd) |
OHC (mean ± sd) [OHC replicate] |
Fold Change (OHC/IHC) |
False Discovery Rate (FDR) |
| 17381533 |
419.16
±
46.65 |
264.40
±
34.82
[203.32]
|
0.63 |
0.336 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
bFGF |
10 |
18 |
25 |
50 |
No bFGF |
40 |
34 |
47 |
31 |
EGF |
11 |
1 |
14 |
9 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
bFGF |
50 |
No bFGF |
31 |
0.62 |
1 |
bFGF |
50 |
EGF |
9 |
0.18 |
2.99e-12 |
No bFGF |
31 |
EGF |
9 |
0.29 |
1.39e-5 |
Chicken Stereocilium Proteomics
| The chicken protein was not reproducibly detected in the chicken stereocilia. |
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1448886_at
| Age |
E12 |
E13 |
E16 |
P0 |
P6 |
P15 |
| Spiral ganglion |
| Replicate 1 |
3741.22
|
2170.56
|
3637.44
|
2157.27
|
599.97
|
1157.78
|
| Replicate 1 Call |
P
|
P
|
P
|
P
|
A
|
A
|
| Replicate 2 |
3684.55
|
2715.49
|
3955.26
|
870.56
|
1014.29
|
376.22
|
| Replicate 2 Call |
P
|
P
|
P
|
A
|
A
|
A
|
| Replicate 3 |
3885
|
2986.2
|
3587.66
|
2157.91
|
150.06
|
1395.91
|
| Replicate 3 Call |
P
|
P
|
P
|
P
|
A
|
P
|
| Replicate 4
|
|
|
4295.71
|
2138.57
|
92.58
|
802.9
|
| Replicate 4 Call |
|
|
P
|
P
|
A
|
A
|
| Mean |
3770.26
|
2624.08
|
3869.02
|
1831.08
|
464.23
|
933.2
|
| Standard Deviation |
103.33
|
415.43
|
327.77
|
640.41
|
431.21
|
444.13
|
| Log2 Mean |
11.88
|
11.34
|
11.91
|
10.74
|
8.24
|
9.71
|
| Log2 Standard Deviation |
0.04
|
0.24
|
0.12
|
0.65
|
1.63
|
0.84
|
| |
| Vestibular ganglion |
| Replicate 1 |
2585.22
|
1199.52
|
245.74
|
102.26
|
60.48
|
97.52
|
| Replicate 1 Call |
P
|
P
|
A
|
A
|
A
|
A
|
| Replicate 2 |
2753.23
|
1172.22
|
267.86
|
139.41
|
76.86
|
83
|
| Replicate 2 Call |
P
|
P
|
A
|
A
|
A
|
A
|
| Replicate 3 |
2715.78
|
1007.59
|
130.21
|
136.75
|
40.85
|
46.29
|
| Replicate 3 Call |
P
|
P
|
A
|
A
|
A
|
A
|
| Mean |
2684.74
|
1126.44
|
214.6
|
126.14
|
59.4
|
75.6
|
| Standard Deviation |
88.2
|
103.83
|
73.92
|
20.72
|
18.03
|
26.4
|
| Log2 Mean |
11.39
|
10.13
|
7.68
|
6.96
|
5.84
|
6.17
|
| Log2 Standard Deviation |
0.05
|
0.14
|
0.57
|
0.25
|
0.46
|
0.57
|
