GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description fat storage-inducing transmembrane protein 2
Synonyms D930001I22Rik; Fit2
Chromosome 2
Genetic Map Distance 84.29 cM
RefSeq Accessions NM_173397; NP_775573
NCBI Entrez Gene 228859 at chr2:163294439-163298365 (mm9) / chr2:163468703-163472629 (mm10)
Ensembl Gene ENSMUSG00000048486
VEGA Gene OTTMUSG00000001072
MGI Gene MGI:2444508
Mouse Protein (1)
UniProt ID Description Length (AA) Predicted # TMs
P59266 Fat storage-inducing transmembrane protein 2 262 5
Pfam Domains Scs3p; UNC-50
Mouse alleles (2)
Allele Name Allele Type
Fitm2tm1(KOMP)Wtsi KOMP-CSD-Project
Fitm2tm1(KOMP)Vlcg KOMP-Regeneron-Project
Human Homolog FITM2 (fat storage-inducing transmembrane protein 2)
Human synonyms C20orf142; dJ881L22.2; Fit2
Human cytoband 20q13.12
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000004301 (C20orf142) encoding ENSGALP00000006842
Gene Ontology
Biological Process (7) cytoskeleton organization; regulation of cell morphogenesis; lipid particle organization; lipid particle organization; cellular triglyceride homeostasis; regulation of triglyceride biosynthetic process; positive regulation of sequestering of triglyceride
Cellular Component (6) integral to membrane; membrane; integral to endoplasmic reticulum membrane; endoplasmic reticulum membrane; endoplasmic reticulum; mitochondrion
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
0
24
15
16
0
Cochlea GFP+ cells
21
5
20
18
22
NA
Utricle GFP- cells
16
8
13
17
24
0
Cochlea GFP- cells
7
8
14
4
11
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
11
GFP+
13
1.15
0.869
Utricle
11
Cochlea
13
1.14
1
Embryonic
9
Postnatal
14
1.61
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17394036 24.20 ± 2.43 41.57 ± 18.17 [27.02] 1.72 0.554
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
203
239
250
231
No bFGF
259
266
311
272
EGF
300
340
309
316
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
231
No bFGF
272
1.18
1
bFGF
231
EGF
316
1.37
0.0378
No bFGF
272
EGF
316
1.16
0.36
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1454935_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 706.9 804.17 1471.43 1463.9 1350.84 1026.51
Replicate 1 Call P P P P P P
Replicate 2 720.98 875.29 1464.65 968.79 1820.76 486.63
Replicate 2 Call P P P P P P
Replicate 3 758.13 984.96 1550.42 1824.55 752.63 2430.47
Replicate 3 Call P P P P P P
Replicate 4 1042.67 1870.7 901.19 2696.05
Replicate 4 Call P P P P
Mean 728.67 888.14 1382.29 1531.99 1206.36 1659.92
Standard Deviation 26.47 91.08 229.74 417.19 482.13 1071.62
Log2 Mean 9.51 9.79 10.42 10.53 10.15 10.39
Log2 Standard Deviation 0.05 0.15 0.26 0.44 0.57 1.16
 
Vestibular ganglion
Replicate 1 844.57 1345.78 729.71 649.65 968.13 1237.49
Replicate 1 Call P P P P P P
Replicate 2 755.33 1115.39 855.31 808.64 869.01 1444.3
Replicate 2 Call P P P P P P
Replicate 3 850.67 1264.84 586.62 886.99 990.22 1310.83
Replicate 3 Call P P P P P P
Mean 816.86 1242 723.88 781.76 942.45 1330.87
Standard Deviation 53.37 116.88 134.44 120.93 64.56 104.85
Log2 Mean 9.67 10.27 9.48 9.6 9.88 10.38
Log2 Standard Deviation 0.1 0.14 0.27 0.23 0.1 0.11