GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description fibroblast growth factor receptor 3
Synonyms HBGFR; sam3; Fgfr-3
Chromosome 5
Genetic Map Distance 17.83 cM
RefSeq Accessions NM_001163215; NM_001163216; NM_001163217; NM_001205270; NM_008010; NP_001156687; NP_001156688; NP_001156689; NP_001192199; NP_032036
NCBI Entrez Gene 14184 at chr5:34064373-34079713 (mm9) / chr5:33721724-33737068 (mm10)
Ensembl Gene ENSMUSG00000054252
VEGA Gene OTTMUSG00000021524
MGI Gene MGI:95524
Mouse Protein (9)
UniProt ID Description Length (AA) Predicted # TMs
Q61851 Fibroblast growth factor receptor 3 801 2
Q3TQL1 Putative uncharacterized protein (Fragment) 762 2
Q3UPE1 Putative uncharacterized protein 801 2
Q61563 Fibroblast growth factor receptor 3, acid box-deleted isoform 782 2
Q7TSI8 Fibroblast growth factor receptor 3 800 2
Q99052 Fibroblast growth factor receptor 800 2
D3Z7U5 Uncharacterized protein 47 0
Q3TQJ1 Putative uncharacterized protein 389 0
Q78EG8 Fibroblast growth factor receptor 3 (Fragment) 123 0
Pfam Domains ig; I-set; Pfam-B_16925; I-set; Pfam-B_7289; Pkinase_Tyr
Mouse alleles (25)
Allele Name Allele Type
Fgfr3tm1e(EUCOMM)Hmgu EUCOMM-projects
Fgfr3tm1a(EUCOMM)Hmgu EUCOMM-projects
Fgfr3m1J Spontaneous
Fgfr3tm1.1Aomw Targeted (knock-in)
Fgfr3tm1.1Iwa Targeted (knock-in)
Fgfr3tm1Aomw Targeted (knock-in)
Fgfr3tm1Cxd Targeted (knock-in)
Fgfr3tm1Dor Targeted (knock-out)
Fgfr3tm1Iwa Targeted (knock-in)
Fgfr3tm1Led Targeted (knock-out)
Fgfr3tm1Llm Targeted (knock-in)
Fgfr3tm1Schl Targeted (knock-out)
Fgfr3tm1Wei Targeted (knock-in)
Fgfr3tm2Cxd Targeted (knock-in)
Fgfr3tm2Schl Targeted (knock-out)
Fgfr3tm2Wei Targeted (knock-in)
Fgfr3tm3.1Cxd Targeted (knock-in)
Fgfr3tm3Cxd Targeted (knock-in)
Fgfr3tm4.1Cxd Targeted (knock-in)
Fgfr3tm4Cxd Targeted (knock-in)
Fgfr3tm5.1Cxd Targeted (knock-in)
Fgfr3tm5Cxd Targeted (knock-in)
Fgfr3tm6.1Cxd Targeted (Floxed/Frt)
Fgfr3tm6.2Cxd Targeted (knock-out)
Fgfr3tm6Cxd Targeted (knock-out)
Human Homolog FGFR3 (fibroblast growth factor receptor 3)
Human synonyms ACH; CD333; CEK2; HSFGFR3EX; JTK4
Human cytoband 4p16.3
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000015708 (FGFR3_CHICK) encoding ENSGALP00000001710
ENSGALG00000015708 (FGFR3_CHICK) encoding ENSGALP00000025286
Gene Ontology
Biological Process (63) positive regulation of canonical Wnt receptor signaling pathway; peptidyl-tyrosine phosphorylation; inner ear development; positive regulation of phospholipase activity; positive regulation of cell differentiation; central nervous system myelination; positive regulation of peptidyl-tyrosine phosphorylation; oligodendrocyte development; positive regulation of apoptotic process; negative regulation of astrocyte differentiation; forebrain development; lens fiber cell development; cochlea development; positive regulation of tyrosine phosphorylation of Stat1 protein; axonogenesis involved in innervation; morphogenesis of an epithelium; alveolar secondary septum development; positive regulation of tyrosine phosphorylation of Stat3 protein; response to axon injury; positive regulation of cell differentiation; substantia nigra development; regulation of apoptotic process; inner ear receptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; inner ear receptor cell differentiation; protein autophosphorylation; lens morphogenesis in camera-type eye; negative regulation of apoptotic process; positive regulation of phosphatidylinositol 3-kinase activity; negative regulation of cell proliferation; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; negative regulation of mitosis; positive regulation of ERK1 and ERK2 cascade; cell differentiation; bone morphogenesis; negative regulation of epithelial cell proliferation; epithelial cell fate commitment; cell-cell signaling; positive regulation of MAPKKK cascade; positive regulation of MAPKKK cascade; positive regulation of MAPKKK cascade; positive regulation of MAPKKK cascade; negative regulation of epithelial cell proliferation; negative regulation of epithelial cell proliferation; protein phosphorylation; cartilage development; signal transduction; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of cell proliferation; positive regulation of cell proliferation; negative regulation of smoothened signaling pathway; positive regulation of endothelial cell proliferation; digestive tract morphogenesis; negative regulation of cell proliferation; somatic stem cell maintenance; MAPKKK cascade; positive regulation of protein ubiquitination; phosphorylation
Cellular Component (9) internal side of plasma membrane; perinuclear region of cytoplasm; cell surface; integral to membrane; membrane; integral to plasma membrane; nucleus; lysosome; cytoplasm
Molecular Function (14) kinase activity; nucleotide binding; transferase activity; receptor activity; ATP binding; protein binding; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; fibroblast growth factor binding; fibroblast growth factor binding; fibroblast growth factor binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
43
17
8
33
36
0
Cochlea GFP+ cells
84
599
501
647
490
NA
Utricle GFP- cells
100
70
35
53
56
0
Cochlea GFP- cells
118
63
33
132
114
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
70
GFP+
223
3.16
0.101
Utricle
37
Cochlea
278
7.33
0.442
Embryonic
137
Postnatal
153
1.12
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17436481 9.24 ± 1.88 25.91 ± 13.01 [54.83] 2.80 0.255
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
2514
2696
3125
2115
No bFGF
4538
4906
5599
4211
EGF
2849
2827
3414
3030
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
2115
No bFGF
4211
1.99
0.455
bFGF
2115
EGF
3030
1.43
0.000915
No bFGF
4211
EGF
3030
0.72
0.000876
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1421841_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 147.99 169.92 202.42 127.59 1156.31 2101.11
Replicate 1 Call P P P A P P
Replicate 2 135.85 112.98 154.28 847.29 1864.43 3840.45
Replicate 2 Call P P P P P P
Replicate 3 155.91 123.19 133.99 133.93 2488.35 1758.76
Replicate 3 Call P P P A P P
Replicate 4 177.52 67.15 1788.45 2262.51
Replicate 4 Call A A P P
Mean 146.58 135.36 167.05 293.99 1824.39 2490.71
Standard Deviation 10.1 30.36 29.53 370.09 544.69 924.02
Log2 Mean 7.19 7.06 7.37 7.46 10.78 11.22
Log2 Standard Deviation 0.1 0.31 0.26 1.58 0.46 0.48
 
Vestibular ganglion
Replicate 1 104.44 79.33 614.06 1527.23 1601.57 1121.21
Replicate 1 Call A P P P P P
Replicate 2 128.19 88.87 988.19 765.65 2476.45 1117.25
Replicate 2 Call P P P P P P
Replicate 3 125.95 70 1530.99 1748.26 2625.43 953.21
Replicate 3 Call A P P P P P
Mean 119.53 79.4 1044.41 1347.05 2234.48 1063.89
Standard Deviation 13.11 9.44 461.04 515.49 553.16 95.87
Log2 Mean 6.9 6.3 9.93 10.31 11.09 10.05
Log2 Standard Deviation 0.16 0.17 0.66 0.64 0.39 0.13
Probe set ID: 1425796_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 30.71 37.95 40.3 40.64 38.71 41.76
Replicate 1 Call A A A A A A
Replicate 2 27.87 36.14 42.62 32.5 32.71 51.2
Replicate 2 Call A A A A A A
Replicate 3 35.78 31.82 37.06 30.61 64.51 39.55
Replicate 3 Call A A A A A A
Replicate 4 30.89 32.02 53.29 26.54
Replicate 4 Call A A A A
Mean 31.45 35.3 37.72 33.94 47.31 39.76
Standard Deviation 4.01 3.15 5.09 4.54 14.36 10.16
Log2 Mean 4.97 5.14 5.23 5.08 5.51 5.27
Log2 Standard Deviation 0.18 0.13 0.2 0.18 0.44 0.4
 
Vestibular ganglion
Replicate 1 18.83 29.7 25.09 24.1 61.53 46.44
Replicate 1 Call A A A A A A
Replicate 2 36.57 20.89 27.23 32.11 48.55 51.26
Replicate 2 Call A A A A A A
Replicate 3 52.44 37.28 21.8 39.71 47.4 44.7
Replicate 3 Call A A A A A A
Mean 35.95 29.29 24.71 31.97 52.49 47.47
Standard Deviation 16.81 8.2 2.74 7.81 7.85 3.4
Log2 Mean 5.05 4.83 4.62 4.97 5.7 5.57
Log2 Standard Deviation 0.75 0.42 0.16 0.36 0.21 0.1