GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description fibroblast growth factor receptor 2
Synonyms Fgfr7; svs; Fgfr-2; KGFRTr; Fgfr-7; Bek
Chromosome 7
Genetic Map Distance 73.19 cM
RefSeq Accessions NP_034337; NP_963895; XM_987418
NCBI Entrez Gene 14183 at chr7:137305965-137410322 (mm9) / chr7:130162451-130266808 (mm10)
Ensembl Gene ENSMUSG00000030849
VEGA Gene OTTMUSG00000031222
MGI Gene MGI:95523
Mouse Protein (24)
UniProt ID Description Length (AA) Predicted # TMs
B7ZWP2 Fgfr2 protein 752 2
B9EKY4 Fgfr2 protein 725 2
P21803 Fibroblast growth factor receptor 2 821 1
A1YYM3 FGFR2 733 1
A1YYM4 FGFR2 822 1
A1YYM5 FGFR2 707 1
A1YYM6 FGFR2 731 1
A1YYM7 FGFR2 724 1
A1YYM8 FGFR2 705 1
A1YYM9 FGFR2 820 1
A1YYN0 FGFR2 813 1
A1YYN1 FGFR2 670 1
A1YYN2 FGFR2 696 1
A1YYN4 FGFR2 608 1
A1YYN5 FGFR2 695 1
A1YYN6 FGFR2 819 1
A1YYN7 FGFR2 698 1
A1YYN8 FGFR2 609 1
A1YYN9 FGFR2 821 1
A1YYP0 FGFR2 704 1
A1YYP1 FGFR2 706 1
D3Z5M8 Uncharacterized protein 709 1
D6RJK5 Uncharacterized protein 334 1
A1YYN3 FGFR2 277 0
Pfam Domains I-set; I-set; Pkinase_Tyr
Mouse alleles (28)
Allele Name Allele Type
Fgfr2tm1(NCOM)Mfgc NorCOMM-projects
Fgfr2tm1(KOMP)Mbp KOMP-CSD-Project
Fgfr2m1Sgg Chemically induced (ENU)
Fgfr2svs Spontaneous
Fgfr2tm1.1Dor Targeted (knock-out)
Fgfr2tm1.1Dsn Targeted (knock-out)
Fgfr2tm1.1Wrst Targeted (knock-out)
Fgfr2tm1Cxd Targeted (knock-out)
Fgfr2tm1Dor Targeted (Floxed/Frt)
Fgfr2tm1Dsn Targeted (Floxed/Frt)
Fgfr2tm1Ewj Targeted (knock-in)
Fgfr2tm1Lni Targeted (knock-out)
Fgfr2tm1Moon Targeted (Reporter)
Fgfr2tm1Schl Targeted (knock-in)
Fgfr2tm1Wrst Targeted (Floxed/Frt)
Fgfr2tm2.1Dsn Targeted (knock-out)
Fgfr2tm2.1Lni Targeted (knock-out)
Fgfr2tm2.2Dsn Targeted (Floxed/Frt)
Fgfr2tm2.3Dsn Targeted (knock-out)
Fgfr2tm2Cxd Targeted (Floxed/Frt)
Fgfr2tm2Dsn Targeted (Floxed/Frt)
Fgfr2tm2Ewj Targeted (knock-in)
Fgfr2tm2Lni Targeted (knock-out)
Fgfr2tm2Schl Targeted (knock-in)
Fgfr2tm3.1Lni Targeted (knock-out)
Fgfr2tm3Dsn Targeted (Reporter)
Fgfr2tm3Lni Targeted (knock-out)
Fgfr2tm4Lni Targeted (knock-in)
Human Homolog FGFR2 (fibroblast growth factor receptor 2)
Human synonyms BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25
Human cytoband 10q26
Known deafness gene No
Within mapped deafness loci DFNB57
Associated Human Disease in OMIM
Chicken homolog (3)
ENSGALG00000009495 (FGFR2_CHICK) encoding ENSGALP00000015441
ENSGALG00000009495 (FGFR2_CHICK) encoding ENSGALP00000015442
ENSGALG00000009495 (FGFR2_CHICK) encoding ENSGALP00000037940
Gene Ontology
Biological Process (130) lacrimal gland development; epithelial cell proliferation; pyramidal neuron development; epithelial cell proliferation; embryonic organ development; epithelial to mesenchymal transition; positive regulation of mesenchymal cell proliferation; in utero embryonic development; limb bud formation; negative regulation of epithelial cell proliferation; branching involved in salivary gland morphogenesis; inner ear morphogenesis; branch elongation involved in salivary gland morphogenesis; ureteric bud development; branch elongation involved in salivary gland morphogenesis; in utero embryonic development; epithelial cell proliferation involved in salivary gland morphogenesis; midbrain development; epithelial cell proliferation involved in salivary gland morphogenesis; regulation of epithelial cell proliferation; branching involved in embryonic placenta morphogenesis; otic vesicle formation; limb bud formation; organ morphogenesis; bone morphogenesis; regulation of epithelial cell proliferation; prostate gland morphogenesis; embryonic digestive tract morphogenesis; lateral sprouting from an epithelium; embryonic digestive tract morphogenesis; branching involved in prostate gland morphogenesis; epithelial cell differentiation; reproductive structure development; embryonic pattern specification; branching involved in prostate gland morphogenesis; organ growth; branching morphogenesis of a nerve; bud elongation involved in lung branching; odontogenesis; lung lobe morphogenesis; regulation of fibroblast growth factor receptor signaling pathway; lung-associated mesenchyme development; lung alveolus development; bone development; post-embryonic development; positive regulation of epithelial cell proliferation involved in lung morphogenesis; multicellular organism growth; regulation of ERK1 and ERK2 cascade; lung alveolus development; positive regulation of phospholipase activity; regulation of smooth muscle cell differentiation; positive regulation of MAPKKK cascade; regulation of cell fate commitment; lung-associated mesenchyme development; protein autophosphorylation; ventricular zone neuroblast division; hair follicle morphogenesis; epidermis morphogenesis; negative regulation of mitosis; positive regulation of cell division; positive regulation of cell cycle; digestive tract development; synaptic vesicle transport; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; positive regulation of epithelial cell proliferation; positive regulation of cardiac muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cardiac muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; ventricular cardiac muscle tissue morphogenesis; negative regulation of transcription from RNA polymerase II promoter; lens fiber cell development; morphogenesis of embryonic epithelium; mesenchymal cell differentiation; bone mineralization; orbitofrontal cortex development; cell fate commitment; embryonic organ morphogenesis; protein phosphorylation; cell-cell signaling; regulation of cell proliferation; positive regulation of cell proliferation; positive regulation of cell proliferation; axonogenesis; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; lung development; lung development; vasculogenesis involved in coronary vascular morphogenesis; positive regulation of Wnt receptor signaling pathway; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; phosphorylation; mesenchymal cell proliferation involved in lung development; neuromuscular junction development; mesenchymal cell differentiation involved in lung development; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of canonical Wnt receptor signaling
Cellular Component (18) cell surface; cell surface; excitatory synapse; cytoplasmic vesicle; extracellular region; cytoplasm; cytoplasm; plasma membrane; integral to plasma membrane; cell cortex; membrane; nucleus; nucleus; nucleus; nucleus; Golgi apparatus; integral to membrane; integral to membrane
Molecular Function (22) protein homodimerization activity; transferase activity; transferring phosphorus-containing groups; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; fibroblast growth factor binding; fibroblast growth factor binding; fibroblast growth factor 1 binding; fibroblast growth factor binding; protein kinase activity; heparin binding; nucleotide binding; protein binding; transferase activity; receptor activity; ATP binding; ATP binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; kinase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
221
447
76
54
84
19
Cochlea GFP+ cells
541
1119
374
212
363
NA
Utricle GFP- cells
13226
6739
3956
1997
4071
1667
Cochlea GFP- cells
4761
3673
3837
8242
23204
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
6852
GFP+
319
0.05
3.21e-6
Utricle
2713
Cochlea
4633
1.71
1
Embryonic
3841
Postnatal
3440
0.90
0.781
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17496947 9.78 ± 0.59 9.96 ± 0.47 [8.94] 1.02 0.829
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
360
388
403
326
No bFGF
662
705
709
520
EGF
372
361
360
365
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
326
No bFGF
520
1.60
1
bFGF
326
EGF
365
1.12
0.511
No bFGF
520
EGF
365
0.70
0.00658
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000015441
Symbol FGFR2
Description Fibroblast growth factor receptor 2
log10 riBAQ in stereocilia (mean ± sd) -4.96 ± ND
log10 riBAQ in utricle (mean ± sd) -4.86 ± 0.05
Molecules per stereocilium (mean ± error with slope error) 16.02 ± ND
Corrected Molecules per stereocilium (mean ± sd) 12.30 ± ND
Stereocilium / Utricle ratio (mean ± sd) 0.79 ± ND
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1420847_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 132.66 260.75 221.23 222.34 325.26 283.53
Replicate 1 Call P P P P P P
Replicate 2 152.32 217.85 212.1 269.11 272.66 322.78
Replicate 2 Call P P P P P P
Replicate 3 108.28 200.87 249.56 240.9 295.2 327.14
Replicate 3 Call P P P P P P
Replicate 4 268.96 233.59 247.37 270.97
Replicate 4 Call P P P P
Mean 131.09 226.49 237.96 241.49 285.12 301.11
Standard Deviation 22.06 30.86 26.1 19.94 33.13 28.08
Log2 Mean 7.02 7.81 7.89 7.91 8.15 8.23
Log2 Standard Deviation 0.25 0.19 0.16 0.12 0.17 0.14
 
Vestibular ganglion
Replicate 1 104.86 198.59 253.91 251.98 213.08 196.03
Replicate 1 Call P P P P P P
Replicate 2 122.55 199.92 243.59 228.04 196.47 217.69
Replicate 2 Call P P P P P P
Replicate 3 120.31 183.62 237.04 225.16 214.58 183.64
Replicate 3 Call P P P P P P
Mean 115.91 194.04 244.85 235.06 208.04 199.12
Standard Deviation 9.63 9.05 8.5 14.72 10.05 17.23
Log2 Mean 6.85 7.6 7.94 7.88 7.7 7.63
Log2 Standard Deviation 0.12 0.07 0.05 0.09 0.07 0.12
Probe set ID: 1433489_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 654.29 534.9 653.99 868.38 1542.34 2301.56
Replicate 1 Call A A A A P P
Replicate 2 636.29 595.51 963.01 1500.19 1411.18 2485.2
Replicate 2 Call A A A P P P
Replicate 3 695.01 604.75 784.95 717.39 2162.33 1284.33
Replicate 3 Call A P A A P P
Replicate 4 1221.32 678.04 1642.86 2292.66
Replicate 4 Call A A P P
Mean 661.86 578.39 905.82 941 1689.68 2090.94
Standard Deviation 30.08 37.94 245.52 381.71 329.07 545.01
Log2 Mean 9.37 9.17 9.78 9.8 10.7 10.98
Log2 Standard Deviation 0.07 0.1 0.39 0.52 0.27 0.44
 
Vestibular ganglion
Replicate 1 715.19 619.55 1459.65 1211.91 933.88 925.2
Replicate 1 Call A A P P M P
Replicate 2 658.75 632.35 1236.2 1028.14 1122.78 900.9
Replicate 2 Call A P P P P P
Replicate 3 790.13 633.29 989.32 930.04 1132.69 1057.34
Replicate 3 Call A A P P P P
Mean 721.36 628.4 1228.39 1056.7 1063.12 961.15
Standard Deviation 65.91 7.68 235.26 143.09 112.03 84.19
Log2 Mean 9.49 9.3 10.24 10.04 10.05 9.91
Log2 Standard Deviation 0.13 0.02 0.28 0.19 0.16 0.12