GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ferrochelatase
Synonyms Fcl; fch
Chromosome 18
Genetic Map Distance 37.43 cM
RefSeq Accessions NM_007998; NP_032024
NCBI Entrez Gene 14151 at chr18:64616204-64648720 (mm9) / chr18:64456542-64489097 (mm10)
Ensembl Gene ENSMUSG00000024588
VEGA Gene
MGI Gene MGI:95513
Mouse Protein (6)
UniProt ID Description Length (AA) Predicted # TMs
P22315 Ferrochelatase, mitochondrial 420 0
Q3UC49 Putative uncharacterized protein 422 0
Q4QRK2 Fech protein (Fragment) 399 0
Q544X6 Putative uncharacterized protein 422 0
Q8C3V7 Putative uncharacterized protein 415 0
Q91W09 Fech protein 395 0
Pfam Domains Ferrochelatase
Mouse alleles (2)
Allele Name Allele Type
Fechm1Pas Chemically induced (ENU)
Fechtm1Dab Targeted (knock-out)
Human Homolog FECH (ferrochelatase)
Human synonyms EPP; FCE
Human cytoband 18q21.3
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000003066 (HEMH_CHICK) encoding ENSGALP00000004832
ENSGALG00000003066 (HEMH_CHICK) encoding ENSGALP00000028757
Gene Ontology
Biological Process (20) detection of UV; heme biosynthetic process; heme biosynthetic process; heme biosynthetic process; heme biosynthetic process; heme biosynthetic process; heme biosynthetic process; cholesterol metabolic process; very-low-density lipoprotein particle assembly; iron ion homeostasis; regulation of eIF2 alpha phosphorylation by heme; regulation of eIF2 alpha phosphorylation by heme; regulation of hemoglobin biosynthetic process; protoporphyrinogen IX metabolic process; protoporphyrinogen IX metabolic process; metabolic process; response to light stimulus; erythrocyte differentiation; heme biosynthetic process; porphyrin-containing compound biosynthetic process
Cellular Component (4) mitochondrion; mitochondrion; mitochondrion; mitochondrial inner membrane
Molecular Function (20) tetrapyrrole binding; tetrapyrrole binding; ferrochelatase activity; ferrochelatase activity; lyase activity; ferrochelatase activity; tetrapyrrole binding; iron-responsive element binding; iron ion binding; tetrapyrrole binding; heme binding; ferrochelatase activity; ferrochelatase activity; ferrochelatase activity; ferrochelatase activity; ferrochelatase activity; ferrochelatase activity; ferrochelatase activity; ferrochelatase activity; ferrochelatase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
73
93
233
351
490
183
Cochlea GFP+ cells
65
132
187
425
712
NA
Utricle GFP- cells
445
355
201
417
538
298
Cochlea GFP- cells
448
250
134
139
226
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
314
GFP+
268
0.85
0.992
Utricle
306
Cochlea
272
0.89
1
Embryonic
233
Postnatal
324
1.39
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17354995 75.59 ± 0.76 32.37 ± 12.76 [15.48] 0.43 0.398
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
626
582
499
751
No bFGF
649
636
585
684
EGF
533
497
495
509
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
751
No bFGF
684
0.91
1
bFGF
751
EGF
509
0.68
0.000758
No bFGF
684
EGF
509
0.74
0.0124
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000004832
Symbol FECH
Description Ferrochelatase
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -4.56 ± 0.08
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1418698_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 547.01 782.57 591.66 477.06 829.84 919.91
Replicate 1 Call P P P P P P
Replicate 2 566.37 587.15 312.04 619.77 492 1318.87
Replicate 2 Call P P P P P P
Replicate 3 583.53 666.55 499.47 203.52 1268.28 795.3
Replicate 3 Call P P P P P P
Replicate 4 337.08 429.36 1057.14 799.94
Replicate 4 Call P P P P
Mean 565.64 678.76 435.06 432.43 911.82 958.51
Standard Deviation 18.27 98.28 133.42 172.72 332.24 247.07
Log2 Mean 9.14 9.4 8.71 8.65 9.75 9.87
Log2 Standard Deviation 0.05 0.21 0.44 0.69 0.59 0.34
 
Vestibular ganglion
Replicate 1 451.83 489.63 5326.3 2316.76 1356.94 1673.75
Replicate 1 Call P P P P P P
Replicate 2 455.25 563.34 4490.12 1862.63 1640.63 1695.32
Replicate 2 Call P P P P P P
Replicate 3 354.55 590.14 3154.97 1245.4 1585.11 1657.62
Replicate 3 Call P P P P P P
Mean 420.54 547.7 4323.8 1808.26 1527.56 1675.56
Standard Deviation 57.18 52.05 1095.18 537.75 150.35 18.92
Log2 Mean 8.71 9.09 12.04 10.77 10.57 10.71
Log2 Standard Deviation 0.21 0.14 0.39 0.45 0.15 0.02
Probe set ID: 1418699_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1381.92 1375.34 1486.59 1624.09 2287.73 2593.96
Replicate 1 Call P P P P P P
Replicate 2 1387.71 1512.69 1170.95 2122.85 1731.68 2916.34
Replicate 2 Call P P P P P P
Replicate 3 1454.11 1510.31 1663.91 1043.28 2874.5 2439.19
Replicate 3 Call P P P P P P
Replicate 4 1595.71 1424.92 2767.01 2369.96
Replicate 4 Call P P P P
Mean 1407.91 1466.11 1479.29 1553.79 2415.23 2579.86
Standard Deviation 40.11 78.62 218.15 449.44 522.23 243.08
Log2 Mean 10.46 10.52 10.52 10.56 11.21 11.33
Log2 Standard Deviation 0.04 0.08 0.23 0.43 0.33 0.13
 
Vestibular ganglion
Replicate 1 1347.17 1535.04 7295.97 3869.29 2669.48 2645.58
Replicate 1 Call P P P P P P
Replicate 2 1304.88 1500.55 5841.03 3264.8 2692.15 2477.08
Replicate 2 Call P P P P P P
Replicate 3 1291.81 1520.51 4121.79 2475.77 2807.66 2589.53
Replicate 3 Call P P P P P P
Mean 1314.62 1518.7 5752.93 3203.29 2723.1 2570.73
Standard Deviation 28.94 17.32 1588.92 698.79 74.11 85.81
Log2 Mean 10.36 10.57 12.45 11.62 11.41 11.33
Log2 Standard Deviation 0.03 0.02 0.42 0.33 0.04 0.05
Probe set ID: 1427696_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 4.37 7.03 5.19 3.37 1.9 3.17
Replicate 1 Call A A A A A A
Replicate 2 1 1.07 9.31 7.34 6.5 1
Replicate 2 Call A A A A A A
Replicate 3 9.89 10.72 3.34 12.39 14.72 1
Replicate 3 Call A A A A A A
Replicate 4 1 14.09 1.81 1
Replicate 4 Call A A A A
Mean 5.09 6.27 4.71 9.3 6.23 1.54
Standard Deviation 4.49 4.87 3.51 4.88 6.07 1.09
Log2 Mean 1.81 2.11 1.83 3.02 2.09 0.42
Log2 Standard Deviation 1.68 1.77 1.36 0.94 1.47 0.83
 
Vestibular ganglion
Replicate 1 20.7 3.32 4.27 20.24 9.48 1.9
Replicate 1 Call A A A A A A
Replicate 2 17.41 5.13 18.25 13.28 1 9.91
Replicate 2 Call A A A A A A
Replicate 3 16.23 9.72 9.21 19.94 2.72 9.8
Replicate 3 Call A A A A A A
Mean 18.11 6.06 10.58 17.82 4.4 7.2
Standard Deviation 2.32 3.3 7.09 3.93 4.48 4.59
Log2 Mean 4.17 2.46 3.16 4.13 1.56 2.51
Log2 Standard Deviation 0.18 0.78 1.05 0.34 1.63 1.37
Probe set ID: 1449181_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 947.85 1124.94 1466.5 1349.71 913.67 1777.91
Replicate 1 Call P P P P P P
Replicate 2 972.3 1196.6 952.31 1280.88 1483.11 953.38
Replicate 2 Call P P P P P P
Replicate 3 1042.02 1236 1160.11 1207.2 1470.21 1163.39
Replicate 3 Call P P P P P P
Replicate 4 750.48 1023.79 1601.52 1366.69
Replicate 4 Call P P P P
Mean 987.39 1185.85 1082.35 1215.4 1367.13 1315.34
Standard Deviation 48.86 56.31 305.87 140.37 308.03 351.53
Log2 Mean 9.95 10.21 10.04 10.24 10.38 10.32
Log2 Standard Deviation 0.07 0.07 0.41 0.17 0.37 0.38
 
Vestibular ganglion
Replicate 1 885.47 1018.7 4108.61 2239.5 2638.49 1919.73
Replicate 1 Call P P P P P P
Replicate 2 865.91 1168.66 3587.47 2164.64 2496.91 1870.2
Replicate 2 Call P P P P P P
Replicate 3 775.13 1276.94 3065.31 1893.62 3160.9 1988.92
Replicate 3 Call P P P P P P
Mean 842.17 1154.77 3587.13 2099.25 2765.43 1926.28
Standard Deviation 58.88 129.68 521.65 181.97 349.72 59.63
Log2 Mean 9.72 10.17 11.8 11.03 11.43 10.91
Log2 Standard Deviation 0.1 0.16 0.21 0.13 0.18 0.04