GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description epidermal growth factor receptor pathway substrate 8
Synonyms
Chromosome 6
Genetic Map Distance 66.78 cM
RefSeq Accessions NM_007945; NP_031971
NCBI Entrez Gene 13860 at chr6:137425766-137597641 (mm9) / chr6:137477245-137649397 (mm10)
Ensembl Gene ENSMUSG00000015766
VEGA Gene OTTMUSG00000022767
MGI Gene MGI:104684
Mouse Protein (9)
UniProt ID Description Length (AA) Predicted # TMs
Q08509 Epidermal growth factor receptor kinase substrate 8 821 0
D3YXC3 Uncharacterized protein 14 0
D3Z5I5 Uncharacterized protein 329 0
D3Z7F4 Uncharacterized protein 189 0
Q3TM41 Putative uncharacterized protein 821 0
Q3TMV3 Putative uncharacterized protein 561 0
Q3U2Z5 Putative uncharacterized protein 847 0
Q3UFL4 Putative uncharacterized protein (Fragment) 463 0
Q3UGL1 Putative uncharacterized protein (Fragment) 587 0
Pfam Domains PTB; Pfam-B_2891; SH3_1
Mouse alleles (2)
Allele Name Allele Type
Eps8tm1a(EUCOMM)Hmgu EUCOMM-projects
Eps8tm1Ppdf Targeted (knock-out)
Human Homolog EPS8 (epidermal growth factor receptor pathway substrate 8)
Human synonyms
Human cytoband 12p12.3
Known deafness gene DFNB102
Within mapped deafness loci DFNB62; Meniere
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000013091 (EPS8) encoding ENSGALP00000021338
Gene Ontology
Biological Process (4) actin filament bundle assembly; behavioral response to ethanol; adult locomotory behavior; actin cytoskeleton reorganization
Cellular Component (3) postsynaptic density; synaptosome; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function (4) protein binding; protein binding; protein binding; protein binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
164
499
105
262
470
496
Cochlea GFP+ cells
69
184
186
198
747
NA
Utricle GFP- cells
636
378
531
293
480
78
Cochlea GFP- cells
293
400
185
184
233
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
335
GFP+
307
0.92
0.909
Utricle
366
Cochlea
268
0.73
1
Embryonic
328
Postnatal
318
0.97
0.984
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17472235 31.53 ± 3.14 36.02 ± 2.54 [38.70] 1.14 0.541
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
2733
2600
2551
3089
No bFGF
2018
1952
1890
2085
EGF
956
897
872
908
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
3089
No bFGF
2085
0.67
0.96
bFGF
3089
EGF
908
0.29
7.71e-42
No bFGF
2085
EGF
908
0.44
8.78e-19
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1422823_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 278.11 355.7 218.04 326.62 504.26 887.86
Replicate 1 Call P P P P P P
Replicate 2 269.53 360.63 210.52 1571.15 583.41 323.56
Replicate 2 Call P P P P P P
Replicate 3 291.28 354.58 151.24 135.61 1117.2 451.16
Replicate 3 Call P P P P P P
Replicate 4 260.21 156.65 1104.32 281.26
Replicate 4 Call P P P P
Mean 279.64 356.97 210 547.51 827.3 485.96
Standard Deviation 10.96 3.22 44.87 687.77 328.95 277.5
Log2 Mean 8.13 8.48 7.69 8.34 9.6 8.77
Log2 Standard Deviation 0.06 0.01 0.33 1.62 0.6 0.74
 
Vestibular ganglion
Replicate 1 159.14 156.51 562.27 796.5 826.86 992.99
Replicate 1 Call P P P P P P
Replicate 2 186.39 201.72 917.29 488.33 1567.61 805.34
Replicate 2 Call P P P P P P
Replicate 3 149.61 196.59 687.93 845.88 1891.65 906.13
Replicate 3 Call P P P P P P
Mean 165.05 184.94 722.5 710.24 1428.71 901.49
Standard Deviation 19.09 24.75 180.02 193.76 545.82 93.91
Log2 Mean 7.36 7.52 9.47 9.43 10.4 9.81
Log2 Standard Deviation 0.16 0.2 0.35 0.43 0.63 0.15
Probe set ID: 1422824_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 439.77 524.33 280.11 493.04 1009.09 1756.16
Replicate 1 Call P P P P P P
Replicate 2 441.29 496.42 315.93 2030.88 743.53 1032.5
Replicate 2 Call P P P P P P
Replicate 3 463.62 539.1 252.76 137.93 1342.91 876.32
Replicate 3 Call P P P A P P
Replicate 4 423.45 176.79 1695.41 484.74
Replicate 4 Call P P P P
Mean 448.23 519.95 318.06 709.66 1197.74 1037.43
Standard Deviation 13.35 21.67 74.87 895.06 412.57 531.67
Log2 Mean 8.81 9.02 8.29 8.63 10.16 9.87
Log2 Standard Deviation 0.04 0.06 0.32 1.76 0.51 0.76
 
Vestibular ganglion
Replicate 1 233.51 284.9 685.56 1050.96 1303.35 1317.8
Replicate 1 Call P P P P P P
Replicate 2 258.05 288.1 1208.03 802.38 1984.18 1052.41
Replicate 2 Call P P P P P P
Replicate 3 184.99 245.18 1105.81 1296.07 2322.22 1158.42
Replicate 3 Call M P P P P P
Mean 225.52 272.73 999.8 1049.8 1869.92 1176.21
Standard Deviation 37.18 23.91 276.9 246.85 518.96 133.59
Log2 Mean 7.8 8.09 9.92 10.01 10.83 10.19
Log2 Standard Deviation 0.25 0.13 0.44 0.35 0.43 0.16
Probe set ID: 1425733_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 39.76 43.3 63.25 84.84 82.57 115.91
Replicate 1 Call A A P A P A
Replicate 2 49.26 50.18 47.62 111 62.44 80.59
Replicate 2 Call A A A A A A
Replicate 3 67.16 33.56 86.83 72.76 68.68 73.99
Replicate 3 Call A A A M A A
Replicate 4 53.15 84.54 84.99 80.02
Replicate 4 Call A A A A
Mean 52.06 42.35 62.71 88.29 74.67 87.63
Standard Deviation 13.91 8.35 17.33 16.15 10.87 19.09
Log2 Mean 5.67 5.38 5.93 6.45 6.21 6.43
Log2 Standard Deviation 0.38 0.29 0.38 0.25 0.21 0.29
 
Vestibular ganglion
Replicate 1 38.51 30.98 65.47 40.22 65.54 76.37
Replicate 1 Call A A A A A P
Replicate 2 48.09 57.54 54.93 64.03 74.57 79.81
Replicate 2 Call A A A A A A
Replicate 3 53.59 55.04 76 94.83 65.16 67.05
Replicate 3 Call A A A A A A
Mean 46.73 47.85 65.47 66.36 68.42 74.41
Standard Deviation 7.63 14.67 10.54 27.38 5.33 6.6
Log2 Mean 5.53 5.53 6.02 5.97 6.09 6.21
Log2 Standard Deviation 0.24 0.5 0.23 0.62 0.11 0.13