GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description epithelial cell adhesion molecule
Synonyms Ly74; gp40; Egp314; CD326; Tacstd1; panepithelial glycoprotein 314; TROP1; EpCAM1; EGP-2; EpCAM; Ep-CAM; GA733-2
Chromosome 17
Genetic Map Distance 57.87 cM
RefSeq Accessions NM_008532; NP_032558
NCBI Entrez Gene 17075 at chr17:88035319-88050467 (mm9) / chr17:87635979-87651127 (mm10)
Ensembl Gene ENSMUSG00000045394
VEGA Gene
MGI Gene MGI:106653
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q99JW5 Epithelial cell adhesion molecule 315 1
Q8CG12 Trop-1 protein (Fragment) 130 1
Pfam Domains Thyroglobulin_1; Pathogen_betaC1; FtsX; DUF1180; DUF1312
Mouse alleles (1)
Allele Name Allele Type
EpcamGt(RST556)Byg Gene trapped
Human Homolog EPCAM (epithelial cell adhesion molecule)
Human synonyms DIAR5; EGP-2; EGP314; EGP40; ESA; HNPCC8; KS1/4; KSA; M4S1; MIC18; MK-1; TACSTD1; TROP1
Human cytoband 2p21
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000008969 (EPCAM_CHICK) encoding ENSGALP00000014571
Gene Ontology
Biological Process (1) positive regulation of cell proliferation
Cellular Component (12) tight junction; cell surface; lateral plasma membrane; lateral plasma membrane; cell junction; integral to membrane; plasma membrane; plasma membrane; membrane; apical plasma membrane; basolateral plasma membrane; tight junction
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
7942
21608
9501
6149
7431
8818
Cochlea GFP+ cells
2902
10912
5362
5532
5043
NA
Utricle GFP- cells
3561
8235
6069
4269
2129
10510
Cochlea GFP- cells
2656
1426
2275
1300
2977
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
4128
GFP+
8291
2.01
0.455
Utricle
8019
Cochlea
4039
0.50
1
Embryonic
7406
Postnatal
5526
0.75
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17340272 226.82 ± 21.76 151.65 ± 31.48 [98.18] 0.67 0.49
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
1
0
0
No bFGF
1
2
0
1
EGF
0
0
0
0
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
0
No bFGF
1
2.10
1
bFGF
0
EGF
0
0.00
0.319
No bFGF
1
EGF
0
0.00
0.0216
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000014571
Symbol EPCAM
Description Epithelial cell adhesion molecule
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -3.92 ± 0.20
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416579_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 150.19 97.73 168.73 332.43 190.77 156.59
Replicate 1 Call A A A P A A
Replicate 2 119.95 100.04 281.25 167.09 268.59 66.84
Replicate 2 Call A A P A A A
Replicate 3 105.81 96.73 208.33 271.2 193.02 154.76
Replicate 3 Call A A P A A A
Replicate 4 179.66 205.01 168.63 215.23
Replicate 4 Call A A A A
Mean 125.32 98.17 209.49 243.93 205.25 148.36
Standard Deviation 22.67 1.7 50.67 73.02 43.64 61.17
Log2 Mean 6.95 6.62 7.68 7.88 7.66 7.09
Log2 Standard Deviation 0.26 0.02 0.33 0.44 0.29 0.72
 
Vestibular ganglion
Replicate 1 147.62 83.28 152.39 240.6 83.2 320.51
Replicate 1 Call A A A A A P
Replicate 2 112.4 60.1 94.83 89.46 464.95 243.21
Replicate 2 Call A A A A P A
Replicate 3 115.49 100.36 87.42 119.81 186.7 206.95
Replicate 3 Call A A A A A A
Mean 125.17 81.25 111.55 149.96 244.95 256.89
Standard Deviation 19.5 20.21 35.56 79.95 197.43 58
Log2 Mean 6.96 6.31 6.76 7.1 7.59 7.98
Log2 Standard Deviation 0.22 0.37 0.43 0.73 1.24 0.32
Probe set ID: 1447899_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1379.87 1508.24 1331.79 1591.29 1960.18 2731.45
Replicate 1 Call P A A P P A
Replicate 2 1543.95 1521.39 1494.48 2247.76 1924.06 2930.75
Replicate 2 Call M A P A P A
Replicate 3 1618.18 1289.97 1528.8 1689.87 1948.88 2053.8
Replicate 3 Call A A P P A A
Replicate 4 1636.9 1730.15 2125.84 2124.22
Replicate 4 Call P P M P
Mean 1514 1439.87 1497.99 1814.77 1989.74 2460.06
Standard Deviation 121.95 129.98 126.33 294.5 91.98 437.05
Log2 Mean 10.56 10.49 10.54 10.81 10.96 11.25
Log2 Standard Deviation 0.12 0.13 0.12 0.22 0.07 0.26
 
Vestibular ganglion
Replicate 1 1586.76 1609.35 2375.83 1985.56 2451.48 1629.03
Replicate 1 Call A A P P A P
Replicate 2 1669.95 1619.88 1865.85 2536.16 2303.67 1739.77
Replicate 2 Call A P A A P A
Replicate 3 1734.66 1541.37 2000.13 2228.8 2207.99 1775.1
Replicate 3 Call A A A A P A
Mean 1663.79 1590.2 2080.6 2250.17 2321.05 1714.63
Standard Deviation 74.14 42.61 264.34 275.92 122.67 76.21
Log2 Mean 10.7 10.63 11.02 11.13 11.18 10.74
Log2 Standard Deviation 0.06 0.04 0.18 0.18 0.08 0.06