MOUSE GENE INFORMATION [PubMed]
| Description | dentin sialophosphoprotein | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Synonyms | Dmp3; Dsp; Dpp | ||||||||||||||||
| Chromosome | 5 | ||||||||||||||||
| Genetic Map Distance | 50.59 cM | ||||||||||||||||
| RefSeq Accessions | NM_010080; NP_034210 | ||||||||||||||||
| NCBI Entrez Gene | 666279 at chr5:104599731-104609146 (mm9) / chr5:104170712-104180127 (mm10) | ||||||||||||||||
| Ensembl Gene | ENSMUSG00000053268 | ||||||||||||||||
| VEGA Gene | |||||||||||||||||
| MGI Gene | MGI:109172 | ||||||||||||||||
| Mouse Protein (3) |
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| Pfam Domains | Pfam-B_4502; Pfam-B_3911; Pfam-B_9044; Pfam-B_3911; Pfam-B_4502; Pfam-B_3911; Pfam-B_9044; Pfam-B_7532 | ||||||||||||||||
| Mouse alleles (2) |
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| Human Homolog | DSPP (dentin sialophosphoprotein) | ||||||||||||||||
| Human synonyms | DFNA39; DGI1; DMP3; DPP; DSP; DTDP2 | ||||||||||||||||
| Human cytoband | 4q21.3 | ||||||||||||||||
| Known deafness gene | DFNA39 | ||||||||||||||||
| Within mapped deafness loci | No | ||||||||||||||||
| Associated Human Disease in OMIM |
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| Chicken homolog (0) |
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Gene Ontology
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FACS-Sorted Hair Cells
Data |
Chart
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
|
|---|---|---|---|---|---|---|
Utricle GFP+ cells |
26 |
1 |
10 |
20 |
0 |
0 |
Cochlea GFP+ cells |
0 |
5 |
0 |
0 |
0 |
NA |
Utricle GFP- cells |
0 |
6 |
3 |
0 |
0 |
15 |
Cochlea GFP- cells |
0 |
8 |
6 |
0 |
0 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
GFP- |
3 |
GFP+ |
5 |
1.51 |
0.894 |
Utricle |
7 |
Cochlea |
2 |
0.34 |
1 |
Embryonic |
6 |
Postnatal |
4 |
0.69 |
1 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID | IHC (mean ± sd) | OHC (mean ± sd) [OHC replicate] | Fold Change (OHC/IHC) | False Discovery Rate (FDR) |
|---|---|---|---|---|
| 17439797 | 8.87 ± 0.66 | 10.99 ± 1.17 [9.92] | 1.24 | 0.501 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
|---|---|---|---|---|
bFGF |
0 |
2 |
1 |
1 |
No bFGF |
1 |
1 |
2 |
1 |
EGF |
0 |
0 |
0 |
0 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
bFGF |
1 |
No bFGF |
1 |
1.40 |
1 |
bFGF |
1 |
EGF |
0 |
0.80 |
0.887 |
No bFGF |
1 |
EGF |
0 |
0.57 |
0.794 |
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Dspp.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1422246_at
| Age | E12 | E13 | E16 | P0 | P6 | P15 |
|---|---|---|---|---|---|---|
| Spiral ganglion | ||||||
| Replicate 1 | 1 | 1 | 1.67 | 1 | 1 | 1 |
| Replicate 1 Call | A | A | A | A | A | A |
| Replicate 2 | 1 | 14.67 | 1 | 1 | 1.33 | 1 |
| Replicate 2 Call | A | A | A | A | A | A |
| Replicate 3 | 1 | 1 | 1 | 1 | 4 | 1 |
| Replicate 3 Call | A | A | A | A | A | A |
| Replicate 4 | 1 | 1 | 11.83 | 1 | ||
| Replicate 4 Call | A | A | A | A | ||
| Mean | 1 | 5.56 | 1.17 | 1 | 4.54 | 1 |
| Standard Deviation | 0 | 7.89 | 0.34 | 0 | 5.04 | 0 |
| Log2 Mean | 0 | 1.29 | 0.18 | 0 | 1.49 | 0 |
| Log2 Standard Deviation | 0 | 2.24 | 0.37 | 0 | 1.63 | 0 |
| Vestibular ganglion | ||||||
| Replicate 1 | 2.5 | 1 | 1 | 1 | 1 | 1 |
| Replicate 1 Call | A | A | A | A | A | A |
| Replicate 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| Replicate 2 Call | A | A | A | A | A | A |
| Replicate 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| Replicate 3 Call | A | A | A | A | A | A |
| Mean | 1.5 | 1 | 1 | 1 | 1 | 1 |
| Standard Deviation | 0.87 | 0 | 0 | 0 | 0 | 0 |
| Log2 Mean | 0.44 | 0 | 0 | 0 | 0 | 0 |
| Log2 Standard Deviation | 0.76 | 0 | 0 | 0 | 0 | 0 |