GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description Dmx-like 2
Synonyms E130119P06Rik; 6430411K14Rik
Chromosome 9
Genetic Map Distance 29.58 cM
RefSeq Accessions NP_766359; XM_358382
NCBI Entrez Gene 235380 at chr9:54212965-54349433 (mm9) / chr9:54365158-54502079 (mm10)
Ensembl Gene ENSMUSG00000041268
VEGA Gene OTTMUSG00000030270
MGI Gene MGI:2444630
Mouse Protein (6)
UniProt ID Description Length (AA) Predicted # TMs
Q8BPN8 DmX-like protein 2 3032 0
B0V2P5 Dmx-like 2 3054 0
B0V2P6 Dmx-like 2 (Fragment) 1311 0
B0V2P7 Dmx-like 2 (Fragment) 2234 0
D6RFA6 Uncharacterized protein 82 0
Q05CM4 Dmxl2 protein 39 0
Pfam Domains Pfam-B_2423; WD40; WD40; PEP-utilisers_N; Pfam-B_14002; Rav1p_C; Pfam-B_19042; Rav1p_C; Pfam-B_19042; Pfam-B_5211; Pfam-B_8183; Pfam-B_15481; WD40; WD40; WD40
Mouse alleles (2)
Allele Name Allele Type
Dmxl2tm1a(EUCOMM)Wtsi EUCOMM-projects
Dmxl2tm1e(EUCOMM)Wtsi EUCOMM-projects
Human Homolog DMXL2 (Dmx-like 2)
Human synonyms RC3
Human cytoband 15q21.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000004805 (LOC776535) encoding ENSGALP00000007662
Gene Ontology
Cellular Component (5) membrane; cell junction; synaptic vesicle; cytoplasmic vesicle; synapse
Molecular Function (1) Rab GTPase binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
1253
1423
1462
1174
2089
732
Cochlea GFP+ cells
1046
543
1866
1068
1825
NA
Utricle GFP- cells
300
392
384
116
640
377
Cochlea GFP- cells
372
345
162
283
380
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
341
GFP+
1316
3.86
0.0244
Utricle
862
Cochlea
789
0.92
1
Embryonic
709
Postnatal
897
1.26
0.799
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17527210 226.82 ± 34.01 144.28 ± 37.68 [90.39] 0.64 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
956
975
886
727
No bFGF
1070
1098
975
892
EGF
1648
1553
1471
1557
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
727
No bFGF
892
1.23
1
bFGF
727
EGF
1557
2.14
1.02e-10
No bFGF
892
EGF
1557
1.75
3.4e-7
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000007662
Symbol DMXL2
Description Dmx-like 2
log10 riBAQ in stereocilia (mean ± sd) -4.61 ± 0.27
log10 riBAQ in utricle (mean ± sd) -3.95 ± 0.08
Molecules per stereocilium (mean ± error with slope error) 36.14 ± 2.34
Corrected Molecules per stereocilium (mean ± sd) 3.34 ± 43.48
Stereocilium / Utricle ratio (mean ± sd) 0.22 ± 0.02
Enriched in the stereocilia (FDR < 0.05) FALSE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1428749_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 5616.28 5436.05 5582.38 5196.55 2739.47 2234.69
Replicate 1 Call P P P P P P
Replicate 2 5688.53 6023.03 4286.05 3976.39 4823.94 1771.21
Replicate 2 Call P P P P P P
Replicate 3 5570.4 5902.53 4401.39 4997.69 1829.2 3777.69
Replicate 3 Call P P P P P P
Replicate 4 3194.18 5204.78 1881.96 4264.88
Replicate 4 Call P P P P
Mean 5625.07 5787.2 4366 4843.85 2818.64 3012.12
Standard Deviation 59.55 310.02 976.45 586.18 1400.46 1197.19
Log2 Mean 12.46 12.5 12.06 12.23 11.34 11.46
Log2 Standard Deviation 0.02 0.08 0.33 0.19 0.65 0.6
 
Vestibular ganglion
Replicate 1 5398.43 5620.32 4935.24 5616.08 5721.31 5821.48
Replicate 1 Call P P P P P P
Replicate 2 5508.54 5834.51 5392.97 5052.65 5189.04 5898.85
Replicate 2 Call P P P P P P
Replicate 3 5235.2 5725.36 5245.44 5467.58 5769.58 6047.85
Replicate 3 Call P P P P P P
Mean 5380.72 5726.73 5191.22 5378.77 5559.98 5922.73
Standard Deviation 137.53 107.1 233.63 292.03 322.15 115.06
Log2 Mean 12.39 12.48 12.34 12.39 12.44 12.53
Log2 Standard Deviation 0.04 0.03 0.07 0.08 0.09 0.03