GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description diaphanous homolog 3 (Drosophila)
Synonyms 4930417P13Rik; mDia2; p134MDia2; Drf3
Chromosome 14
Genetic Map Distance 43.95 cM
RefSeq Accessions NM_019670; NP_062644
NCBI Entrez Gene 56419 at chr14:87056130-87540921 (mm9) / chr14:86656323-87141251 (mm10)
Ensembl Gene ENSMUSG00000022021
VEGA Gene
MGI Gene MGI:1927222
Mouse Protein (9)
UniProt ID Description Length (AA) Predicted # TMs
Q9Z207 Protein diaphanous homolog 3 1171 0
Q0VGT1 Diaphanous homolog 3 (Drosophila) 1171 0
Q3TLZ9 Putative uncharacterized protein 113 0
Q3TSX1 Putative uncharacterized protein (Fragment) 999 0
Q3UU77 Putative uncharacterized protein (Fragment) 1001 0
Q3UVP0 Putative uncharacterized protein (Fragment) 656 0
Q5DTM7 MKIAA4117 protein (Fragment) 1192 0
Q5PR81 Diap3 protein (Fragment) 1147 0
Q8K331 Diap3 protein 929 0
Pfam Domains Pfam-B_980; Drf_GBD; Drf_FH3; Pfam-B_2472; Pfam-B_18774; Pfam-B_7278; FH2; Drf_DAD
Mouse alleles (4)
Allele Name Allele Type
Diap3tm1(NCOM)Mfgc NorCOMM-projects
Diap3tm1e(KOMP)Mbp KOMP-CSD-Project
Diap3tm1a(KOMP)Mbp KOMP-CSD-Project
Diap3tm1(KOMP)Vlcg KOMP-Regeneron-Project
Human Homolog DIAPH3 (diaphanous homolog 3 (Drosophila))
Human synonyms AN; AUNA1; diap3; DRF3; mDia2; NSDAN
Human cytoband 13q21.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (4)
ENSGALG00000016937 (DIAPH3) encoding ENSGALP00000027326
ENSGALG00000016937 (DIAPH3) encoding ENSGALP00000035720
ENSGALG00000016937 (DIAPH3) encoding ENSGALP00000035721
ENSGALG00000016937 (DIAPH3) encoding ENSGALP00000035722
Gene Ontology
Biological Process (2) actin cytoskeleton organization; cellular component organization
Cellular Component (2) nucleus; cytoplasm
Molecular Function (3) actin binding; Rho GTPase binding; binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
13
17
0
6
0
19
Cochlea GFP+ cells
16
10
0
0
1
NA
Utricle GFP- cells
22
2
15
35
9
0
Cochlea GFP- cells
25
11
4
11
3
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
13
GFP+
7
0.59
0.708
Utricle
11
Cochlea
8
0.72
1
Embryonic
14
Postnatal
7
0.52
0.644
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17308965 7.76 ± 0.81 8.79 ± 2.75 [14.50] 1.13 0.674
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
285
225
217
353
No bFGF
216
204
184
182
EGF
190
190
184
188
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
353
No bFGF
182
0.51
0.4
bFGF
353
EGF
188
0.53
1.1e-6
No bFGF
182
EGF
188
1.04
0.906
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000027326
Symbol DIAPH3
Description Diaphanous homolog 3
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -6.28 ± 0.32
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1422944_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 0.95 1.19 1 1 1.59 1
Replicate 1 Call A A A A A A
Replicate 2 1 1 1 1 1 1.38
Replicate 2 Call A A A A A A
Replicate 3 2.31 3.3 3.72 1 1 1
Replicate 3 Call A A A A A A
Replicate 4 4.12 1 1 1
Replicate 4 Call A A A A
Mean 1.42 1.83 2.46 1 1.15 1.1
Standard Deviation 0.77 1.28 1.69 0 0.3 0.19
Log2 Mean 0.38 0.66 0.98 0 0.17 0.12
Log2 Standard Deviation 0.72 0.93 1.14 0 0.33 0.23
 
Vestibular ganglion
Replicate 1 3.59 1 6.11 2.43 1 1.19
Replicate 1 Call A A A A A A
Replicate 2 2.87 5.18 1 1 8.69 1
Replicate 2 Call A A A A A A
Replicate 3 1 1 1 1 3.28 5.25
Replicate 3 Call A A A A A P
Mean 2.49 2.39 2.7 1.48 4.32 2.48
Standard Deviation 1.34 2.41 2.95 0.83 3.95 2.4
Log2 Mean 1.12 0.79 0.87 0.43 1.61 0.88
Log2 Standard Deviation 0.98 1.37 1.51 0.74 1.56 1.31