GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description chemokine (C-X-C motif) ligand 10
Synonyms mob-1; C7; IP-10; gIP-10; Scyb10; INP10; IP10; CRG-2; Ifi10
Chromosome 5
Genetic Map Distance 46.57 cM
RefSeq Accessions NM_021274; NP_067249
NCBI Entrez Gene 15945 at chr5:92775667-92777880 (mm9) / chr5:92346638-92348889 (mm10)
Ensembl Gene ENSMUSG00000034855
VEGA Gene OTTMUSG00000028740
MGI Gene MGI:1352450
Mouse Protein (7)
UniProt ID Description Length (AA) Predicted # TMs
P17515 C-X-C motif chemokine 10 98 1
D3YW23 Uncharacterized protein 93 1
Q3UAS6 Putative uncharacterized protein 98 1
Q3UCV1 Putative uncharacterized protein 98 1
Q3UK71 Putative uncharacterized protein 98 1
Q548V9 Chemokine (C-X-C motif) ligand 10 98 1
Q3U6X5 Putative uncharacterized protein (Fragment) 67 0
Pfam Domains IL8
Mouse alleles (1)
Allele Name Allele Type
Cxcl10tm1Adl Targeted (knock-out)
Human Homolog CXCL10 (chemokine (C-X-C motif) ligand 10)
Human synonyms C7; crg-2; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10
Human cytoband 4q21
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (0)
Gene Ontology
Biological Process (10) inflammatory response; positive regulation of leukocyte chemotaxis; immune response; positive regulation of cell proliferation; protein secretion; negative regulation of angiogenesis; positive regulation of cell migration; defense response to virus; signal transduction; chemotaxis
Cellular Component (7) extracellular space; extracellular space; cell; external side of plasma membrane; extracellular region; extracellular region; extracellular space
Molecular Function (3) cytokine activity; cytokine activity; chemokine activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
0
0
2
0
13
Cochlea GFP+ cells
0
3
0
0
1
NA
Utricle GFP- cells
2
2
42
66
54
31
Cochlea GFP- cells
3
0
18
138
32
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
35
GFP+
2
0.07
0.00602
Utricle
18
Cochlea
20
1.10
1
Embryonic
2
Postnatal
28
13.53
0.0173
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17449718 11.91 ± 0.95 12.59 ± 1.66 [16.40] 1.06 0.617
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
1
2
34
No bFGF
0
2
1
1
EGF
3
1
8
4
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
34
No bFGF
1
0.05
4.8e-5
bFGF
34
EGF
4
0.13
1.26e-11
No bFGF
1
EGF
4
2.91
0.145
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Cxcl10.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1418930_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 10.2 11.12 6.18 728.24 453.51 1234.09
Replicate 1 Call A A A P P P
Replicate 2 13.58 16.86 20.14 2414.18 676.2 1920.51
Replicate 2 Call A A A P P P
Replicate 3 6.95 19.78 20.3 64.9 156.61 859.06
Replicate 3 Call A A A A M P
Replicate 4 13.68 60.13 593.86 679.41
Replicate 4 Call A A P P
Mean 10.24 15.92 15.08 816.86 470.05 1173.27
Standard Deviation 3.32 4.41 6.68 1110.16 228.29 549.15
Log2 Mean 3.3 3.95 3.77 8.17 8.68 10.08
Log2 Standard Deviation 0.48 0.43 0.81 2.64 0.96 0.65
 
Vestibular ganglion
Replicate 1 12.49 11.93 34.88 181.6 154.84 112.43
Replicate 1 Call A A A A A A
Replicate 2 11.9 11.38 63.02 263.65 179.64 87.19
Replicate 2 Call A A A A A P
Replicate 3 13.91 10.98 33.06 111.65 212.49 140.12
Replicate 3 Call A A A A A P
Mean 12.77 11.43 43.65 185.63 182.32 113.25
Standard Deviation 1.03 0.48 16.8 76.08 28.92 26.47
Log2 Mean 3.67 3.51 5.38 7.45 7.5 6.8
Log2 Standard Deviation 0.12 0.06 0.52 0.62 0.23 0.34