SHIELD | Shared Harvard Inner-Ear Laboratory Database

MOUSE GENE INFORMATION [PubMed]

Description

coproporphyrinogen oxidase

Synonyms

nct; cac; Cpo; clone 560

Chromosome

Genetic Map Distance

34.80 cM

RefSeq Accessions

NM_007757; NP_031783

NCBI Entrez Gene

12892 at chr16:58670321-58680504 (mm9) / chr16:58670208-58680391 (mm10)

Ensembl Gene

ENSMUSG00000022742

VEGA Gene

MGI Gene

MGI:104841

Mouse Protein (2)

UniProt ID	Description	Length (AA)	Predicted # TMs
P36552	Coproporphyrinogen-III oxidase, mitochondrial	443	0
Q3U029	Putative uncharacterized protein	380	0

Pfam Domains

Coprogen_oxidas

Mouse alleles (2)

Allele Name	Allele Type
Cpox^{tm1a(KOMP)Wtsi}	KOMP-CSD-Project
Cpox^{tm2e(KOMP)Wtsi}	KOMP-CSD-Project

Human Homolog

CPOX (coproporphyrinogen oxidase)

Human synonyms

CPO; CPX; HCP

Human cytoband

3q12

Known deafness gene

Within mapped deafness loci

Associated Human Disease in OMIM

Coproporphyria, Hereditary; HCP [Coproporphyrinogen Oxidase Deficiency|CPO Deficiency|Cpox Deficiency]

Chicken homolog (1)

ENSGALG00000015240 (CPOX) encoding ENSGALP00000024546

Gene Ontology

Biological Process (7)	oxidation-reduction process; oxidation-reduction process; protoporphyrinogen IX biosynthetic process; porphyrin-containing compound biosynthetic process; porphyrin-containing compound biosynthetic process; heme biosynthetic process; heme biosynthetic process
Cellular Component (9)	cytoplasm; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; mitochondrion; mitochondrion; mitochondrion; mitochondrion; mitochondrion
Molecular Function (5)	identical protein binding; oxidoreductase activity; coproporphyrinogen oxidase activity; coproporphyrinogen oxidase activity; protein homodimerization activity

FACS-Sorted Hair Cells

Data | Chart

	E16a	E16b	P0	P4	P7	P16
Utricle GFP+ cells	108	184	301	292	254	451
Cochlea GFP+ cells	177	144	167	440	95	NA
Utricle GFP- cells	153	152	119	321	138	393
Cochlea GFP- cells	176	112	147	121	148	NA

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
GFP-	180	GFP+	238	1.32	0.791
Utricle	239	Cochlea	173	0.72	1
Embryonic	151	Postnatal	242	1.60	1

Adult Cochlear Inner and Outer Hair Cells

Probeset ID	IHC (mean ± sd)	OHC (mean ± sd) [OHC replicate]	Fold Change (OHC/IHC)	False Discovery Rate (FDR)
17326428	10.96 ± 1.98	10.14 ± 1.61 [10.00]	0.93	0.835

Otic Progenitor Cells

Data

Growth Factor	Replicate 1	Replicate 2	Replicate 3	Mean
bFGF	644	649	802	739
No bFGF	556	558	575	622
EGF	436	419	400	418

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
bFGF	739	No bFGF	622	0.84	1
bFGF	739	EGF	418	0.57	3.72e-7
No bFGF	622	EGF	418	0.67	0.000697

Chicken Stereocilium Proteomics

Protein ID	ENSGALP00000024546
Symbol	CPOX
Description	Coproporphyrinogen oxidase
log10 riBAQ in stereocilia (mean ± sd)	ND
log10 riBAQ in utricle (mean ± sd)	-5.03 ± 0.31
Molecules per stereocilium (mean ± error with slope error)	ND
Corrected Molecules per stereocilium (mean ± sd)	ND
Stereocilium / Utricle ratio (mean ± sd)	UTR only
Enriched in the stereocilia (FDR < 0.05)	NA

Auditory and Vestibular Ganglion Neurons

Probe set ID: 1422492_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	2205.24	1880.42	2325.1	2075.01	1409.43	2216.7
Replicate 1 Call	P	A	P	P	P	P
Replicate 2	2202.3	2131.86	2284.35	2245.89	2115.97	1932.35
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	2250.68	2321.16	2321.95	1874	1817.13	2160.36
Replicate 3 Call	P	P	P	P	P	P
Replicate 4			1868.58	2440	2008.72	2638.04
Replicate 4 Call			P	P	P	P
Mean	2219.41	2111.15	2200	2158.73	1837.81	2236.86
Standard Deviation	27.12	221.1	221.72	241.38	311.19	294.35
Log2 Mean	11.12	11.04	11.1	11.07	10.83	11.12
Log2 Standard Deviation	0.02	0.15	0.15	0.16	0.26	0.19

Vestibular ganglion
Replicate 1	2059.24	2538.01	3387.16	2859.5	3363.44	2615.27
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	2025.95	2262.47	3524.26	2584.43	4166.42	2077.23
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	2092.37	2475.59	3051.86	2566.88	3909.94	2550.8
Replicate 3 Call	P	P	P	P	P	P
Mean	2059.19	2425.36	3321.09	2670.27	3813.27	2414.43
Standard Deviation	33.21	144.48	243.03	164.11	410.13	293.8
Log2 Mean	11.01	11.24	11.69	11.38	11.89	11.23
Log2 Standard Deviation	0.02	0.09	0.11	0.09	0.16	0.18

Probe set ID: 1422493_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	204.18	192.07	212.54	202.09	164.99	160.49
Replicate 1 Call	P	P	P	P	A	M
Replicate 2	191.76	194.33	255.82	202.2	174.31	175.65
Replicate 2 Call	P	P	P	P	P	M
Replicate 3	174.12	157.53	225.12	183.65	203.46	238.83
Replicate 3 Call	P	P	P	P	P	P
Replicate 4			261.12	192.95	157.52	180.22
Replicate 4 Call			P	P	A	A
Mean	190.02	181.31	238.65	195.22	175.07	188.8
Standard Deviation	15.11	20.63	23.55	8.85	20.13	34.4
Log2 Mean	7.57	7.5	7.89	7.61	7.44	7.54
Log2 Standard Deviation	0.12	0.17	0.14	0.07	0.16	0.25

Vestibular ganglion
Replicate 1	211.11	170.79	197.87	176.4	154.53	131.42
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	208.2	137.23	102.25	205.28	207.81	88.51
Replicate 2 Call	P	P	M	M	P	P
Replicate 3	248.67	173.82	121.81	204.84	140.07	96.79
Replicate 3 Call	P	P	A	P	P	P
Mean	222.66	160.61	140.64	195.51	167.47	105.57
Standard Deviation	22.57	20.31	50.52	16.55	35.68	22.76
Log2 Mean	7.79	7.32	7.08	7.61	7.37	6.7
Log2 Standard Deviation	0.14	0.19	0.49	0.13	0.3	0.3

GENE VIEW

Cpox