GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description collagen, type XI, alpha 2
Synonyms
Chromosome 17
Genetic Map Distance 17.98 cM
RefSeq Accessions NM_009926; NP_034056
NCBI Entrez Gene 12815 at chr17:34176382-34203187 (mm9) / chr17:34038506-34066684 (mm10)
Ensembl Gene ENSMUSG00000024330
VEGA Gene OTTMUSG00000022512
MGI Gene MGI:88447
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q64739 Collagen alpha-2(XI) chain 1736 1
Q3UUU1 Putative uncharacterized protein (Fragment) 771 0
Pfam Domains Laminin_G_2; Pfam-B_6080; Collagen; Pfam-B_5239; Collagen; Collagen; Pfam-B_544; Pfam-B_544; Pfam-B_5239; Pfam-B_5239; Collagen; Collagen; Pfam-B_5239; Collagen; Pfam-B_544; Collagen; Pfam-B_5239; Pfam-B_544; Pfam-B_544; Pfam-B_5239; Collagen; Pfam-B_10794; COLFI; COLFI
Mouse alleles (2)
Allele Name Allele Type
Col11a2tm1a(KOMP)Wtsi KOMP-CSD-Project
Col11a2tm1Mne Targeted (knock-out)
Human Homolog COL11A2 (collagen, type XI, alpha 2)
Human synonyms DFNA13; DFNB53; HKE5; PARP; STL3
Human cytoband 6p21.3
Known deafness gene DFNA13/DFNB53/STL3
Within mapped deafness loci DFNA21; DFNA31; OTSC3
Associated Human Disease in OMIM
Chicken homolog (0)
Gene Ontology
Biological Process (14) tissue homeostasis; ossification; skeletal system development; cartilage development; palate development; soft palate development; collagen fibril organization; sensory perception of sound; sensory perception of sound; sensory perception of sound; skeletal system morphogenesis; chondrocyte differentiation; collagen fibril organization; collagen fibril organization
Cellular Component (4) extracellular region; proteinaceous extracellular matrix; collagen type XI; collagen
Molecular Function (1) extracellular matrix structural constituent
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
8
5
0
9
14
13
Cochlea GFP+ cells
0
26
5
11
27
NA
Utricle GFP- cells
3
22
48
114
161
94
Cochlea GFP- cells
6
35
23
144
173
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
75
GFP+
11
0.15
0.0778
Utricle
41
Cochlea
45
1.10
1
Embryonic
13
Postnatal
60
4.43
0.099
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17336338 23.13 ± 1.32 20.90 ± 1.94 [16.63] 0.90 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
106
126
172
116
No bFGF
170
183
229
183
EGF
142
198
200
180
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
116
No bFGF
183
1.58
1
bFGF
116
EGF
180
1.55
0.0122
No bFGF
183
EGF
180
0.98
1
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Col11a2.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1423578_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 48.05 49.97 65.82 77.52 809.95 237.57
Replicate 1 Call A A A A P A
Replicate 2 40.13 59.63 123.75 109.63 167.19 141.36
Replicate 2 Call A A A A A A
Replicate 3 57.07 46.62 120.73 64.27 1542.97 163.28
Replicate 3 Call A A P A P A
Replicate 4 134.11 59.18 1820.65 201.46
Replicate 4 Call P A P A
Mean 48.42 52.07 111.1 77.65 1085.19 185.92
Standard Deviation 8.48 6.76 30.73 22.68 745.87 42.46
Log2 Mean 5.58 5.69 6.74 6.24 9.62 7.51
Log2 Standard Deviation 0.25 0.18 0.47 0.4 1.57 0.33
 
Vestibular ganglion
Replicate 1 43.02 51.32 21.48 42.68 43.56 60.46
Replicate 1 Call A A A A A A
Replicate 2 43.66 41.32 21.49 34 84.34 34.61
Replicate 2 Call A A A A A P
Replicate 3 59.75 44.2 32.33 44.88 50.65 54.65
Replicate 3 Call A A A A A P
Mean 48.81 45.61 25.1 40.52 59.52 49.91
Standard Deviation 9.48 5.15 6.26 5.75 21.79 13.56
Log2 Mean 5.59 5.51 4.62 5.33 5.84 5.6
Log2 Standard Deviation 0.27 0.16 0.34 0.21 0.5 0.43