GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description collagen, type XI, alpha 1
Synonyms C530001D20Rik
Chromosome 3
Genetic Map Distance 49.35 cM
RefSeq Accessions NM_007729; NP_031755
NCBI Entrez Gene 12814 at chr3:113733458-113923244 (mm9) / chr3:114030479-114220327 (mm10)
Ensembl Gene ENSMUSG00000027966
VEGA Gene OTTMUSG00000022509
MGI Gene MGI:88446
Mouse Protein (21)
UniProt ID Description Length (AA) Predicted # TMs
Q61245 Collagen alpha-1(XI) chain 1804 0
Q3TST6 Putative uncharacterized protein (Fragment) 1286 0
Q3TTT4 Putative uncharacterized protein (Fragment) 241 0
Q3UST0 Putative uncharacterized protein (Fragment) 383 0
Q61246 Alpha 1 type XI collagen (Fragment) 187 0
Q80WR4 Collagen, type XI, alpha 1 1804 0
Q8C4S5 Putative uncharacterized protein (Fragment) 275 0
Q8C6X0 Putative uncharacterized protein (Fragment) 262 0
Q8VIA2 A1(XI) collagen (Fragment) 73 0
Q8VIA3 A1(XI) collagen (Fragment) 124 0
Q8VIA4 A1(XI) collagen (Fragment) 112 0
Q8VIA5 A1(XI) collagen (Fragment) 158 0
Q8VIA6 A1(XI) collagen (Fragment) 209 0
Q8VIA7 A1(XI) collagen (Fragment) 197 0
Q8VIA8 A1(XI) collagen (Fragment) 248 0
Q9EQU6 A1(XI) collagen (Fragment) 324 0
Q9EQU7 A1(XI) collagen (Fragment) 409 0
Q9EQU8 A1(XI) collagen (Fragment) 375 0
Q9EQU9 A1(XI) collagen (Fragment) 363 0
Q9EQV0 A1(XI) collagen (Fragment) 460 0
Q9EQV1 A1(XI) collagen (Fragment) 448 0
Pfam Domains Pfam-B_38; Laminin_G_2; Pfam-B_6080; Collagen; Collagen; Collagen; Collagen; Collagen; Pfam-B_544; Pfam-B_5239; Pfam-B_544; Pfam-B_544; Pfam-B_5239; Pfam-B_5239; Pfam-B_5239; Collagen; Collagen; Pfam-B_544; Collagen; Pfam-B_10794; COLFI
Mouse alleles (1)
Allele Name Allele Type
Col11a1cho Spontaneous
Human Homolog COL11A1 (collagen, type XI, alpha 1)
Human synonyms CO11A1; COLL6; STL2
Human cytoband 1p21
Known deafness gene STL2
Within mapped deafness loci DFNA37; WS2B
Associated Human Disease in OMIM
Chicken homolog (3)
ENSGALG00000005180 (Q90796_CHICK) encoding ENSGALP00000008306
ENSGALG00000005180 (Q90796_CHICK) encoding ENSGALP00000008307
ENSGALG00000005180 (Q90796_CHICK) encoding ENSGALP00000008308
Gene Ontology
Biological Process (23) cartilage development; ventricular cardiac muscle tissue morphogenesis; heart morphogenesis; collagen fibril organization; collagen fibril organization; collagen fibril organization; collagen fibril organization; collagen fibril organization; proteoglycan metabolic process; inner ear morphogenesis; cartilage condensation; cartilage development; cartilage development; cartilage development; chondrocyte development; embryonic skeletal system morphogenesis; cartilage development; skeletal system morphogenesis; collagen fibril organization; collagen fibril organization; visual perception; sensory perception of sound; detection of mechanical stimulus involved in sensory perception of sound
Cellular Component (6) extracellular matrix; extracellular matrix; proteinaceous extracellular matrix; collagen; collagen type XI; extracellular region
Molecular Function (2) molecular_function; extracellular matrix structural constituent
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
433
817
279
283
411
84
Cochlea GFP+ cells
478
4363
299
724
320
NA
Utricle GFP- cells
1857
2468
2747
1692
3138
456
Cochlea GFP- cells
1759
3094
3246
2842
6218
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
2683
GFP+
772
0.29
0.0928
Utricle
1222
Cochlea
2334
1.91
1
Embryonic
1909
Postnatal
1624
0.85
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17401902 19.33 ± 1.86 14.94 ± 1.53 [17.01] 0.77 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
676
676
724
520
No bFGF
507
519
476
375
EGF
470
473
450
464
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
520
No bFGF
375
0.72
0.787
bFGF
520
EGF
464
0.89
0.443
No bFGF
375
EGF
464
1.24
0.103
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000008307
Symbol COL11A1
Description Collagen, type XI, alpha 1
log10 riBAQ in stereocilia (mean ± sd) -5.47 ± 0.29
log10 riBAQ in utricle (mean ± sd) -4.19 ± 0.19
Molecules per stereocilium (mean ± error with slope error) 5.00 ± 0.31
Corrected Molecules per stereocilium (mean ± sd) -14.41 ± 24.07
Stereocilium / Utricle ratio (mean ± sd) 0.05 ± 0.00
Enriched in the stereocilia (FDR < 0.05) FALSE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1418599_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1588.45 2296.04 876.44 1280.21 3381.83 2538.9
Replicate 1 Call P P P P P P
Replicate 2 1597.37 2641.95 805.09 2209.14 2287.92 3117.74
Replicate 2 Call P P P P P P
Replicate 3 1639.02 2637.47 786.24 572.04 3721.06 2419.67
Replicate 3 Call P P P P P P
Replicate 4 870.1 549.87 3444.64 2671.49
Replicate 4 Call P P P P
Mean 1608.28 2525.15 834.47 1152.82 3208.86 2686.95
Standard Deviation 26.99 198.43 45.53 781.64 631.4 305.06
Log2 Mean 10.65 11.3 9.7 9.92 11.62 11.39
Log2 Standard Deviation 0.02 0.12 0.08 0.97 0.32 0.16
 
Vestibular ganglion
Replicate 1 1846.2 2092.82 2368.77 1655.33 1849.11 2208.69
Replicate 1 Call P P P P P P
Replicate 2 1669.5 2096.57 2590.12 1699.83 2817.08 1280.79
Replicate 2 Call P P P P P P
Replicate 3 1747.83 2152.81 1937.76 1380.29 2219.97 1651.05
Replicate 3 Call P P P P P P
Mean 1754.51 2114.07 2298.88 1578.48 2295.39 1713.51
Standard Deviation 88.54 33.61 331.75 173.08 488.37 467.09
Log2 Mean 10.78 11.05 11.16 10.62 11.14 10.71
Log2 Standard Deviation 0.07 0.02 0.21 0.16 0.3 0.39
Probe set ID: 1449154_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1475.94 4397.05 2073.89 2842.73 7233.26 4050.81
Replicate 1 Call P P P P P P
Replicate 2 1612.28 4761.28 1305.95 5027.82 4690.96 6032.31
Replicate 2 Call P P P P P P
Replicate 3 1764.12 4579.94 1919.03 1604.63 8104.11 4343.54
Replicate 3 Call P P P P P P
Replicate 4 1460.23 1368.31 7853.89 4602
Replicate 4 Call P P P P
Mean 1617.45 4579.42 1689.78 2710.87 6970.56 4757.17
Standard Deviation 144.16 182.12 365.2 1674.5 1563.2 879.41
Log2 Mean 10.66 12.16 10.7 11.21 12.73 12.2
Log2 Standard Deviation 0.13 0.06 0.32 0.85 0.37 0.25
 
Vestibular ganglion
Replicate 1 1667.31 2894.83 4512.24 3500.33 3669.37 2971.35
Replicate 1 Call P P P P P P
Replicate 2 1590.57 3548.54 5753.41 4079.23 5976.96 1599.65
Replicate 2 Call P P P P P P
Replicate 3 1378.65 3250.61 4676.98 3008.24 5052.46 2119.71
Replicate 3 Call P P P P P P
Mean 1545.51 3231.33 4980.88 3529.27 4899.6 2230.24
Standard Deviation 149.51 327.28 674.09 536.08 1161.36 692.5
Log2 Mean 10.59 11.65 12.27 11.77 12.23 11.08
Log2 Standard Deviation 0.14 0.15 0.19 0.22 0.36 0.45