MOUSE GENE INFORMATION [PubMed]
| Description | claudin 14 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Synonyms | |||||||||||||
| Chromosome | 16 | ||||||||||||
| Genetic Map Distance | 54.99 cM | ||||||||||||
| RefSeq Accessions | NM_001165925; NM_001165926; NM_019500; NP_001159397; NP_001159398; NP_062373 | ||||||||||||
| NCBI Entrez Gene | 56173 at chr16:93919276-94009082 (mm9) / chr16:93919031-94008837 (mm10) | ||||||||||||
| Ensembl Gene | ENSMUSG00000047109 | ||||||||||||
| VEGA Gene | OTTMUSG00000019962 | ||||||||||||
| MGI Gene | MGI:1860425 | ||||||||||||
| Mouse Protein (2) |
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| Pfam Domains | PMP22_Claudin; DUF2319; Laminin_EGF; CD20; DGF-1_C | ||||||||||||
| Mouse alleles (2) |
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| Human Homolog | CLDN14 (claudin 14) | ||||||||||||
| Human synonyms | DFNB29 | ||||||||||||
| Human cytoband | 21q22.3 | ||||||||||||
| Known deafness gene | DFNB29 | ||||||||||||
| Within mapped deafness loci | No | ||||||||||||
| Associated Human Disease in OMIM | |||||||||||||
| Chicken homolog (1) |
ENSGALG00000016043 (CLDN14) encoding ENSGALP00000035953
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Gene Ontology
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FACS-Sorted Hair Cells
Data |
Chart
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
|
|---|---|---|---|---|---|---|
Utricle GFP+ cells |
21 |
7 |
86 |
167 |
228 |
248 |
Cochlea GFP+ cells |
4 |
16 |
234 |
875 |
668 |
NA |
Utricle GFP- cells |
2 |
16 |
2 |
82 |
12 |
0 |
Cochlea GFP- cells |
1 |
1 |
8 |
8 |
7 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
GFP- |
13 |
GFP+ |
232 |
17.75 |
2.07e-7 |
Utricle |
73 |
Cochlea |
182 |
2.50 |
0.886 |
Embryonic |
8 |
Postnatal |
187 |
20.89 |
1.43e-5 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID | IHC (mean ± sd) | OHC (mean ± sd) [OHC replicate] | Fold Change (OHC/IHC) | False Discovery Rate (FDR) |
|---|---|---|---|---|
| 17332290 | 45.58 ± 1.99 | 49.26 ± 5.13 [56.43] | 1.08 | 0.615 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
|---|---|---|---|---|
bFGF |
0 |
1 |
1 |
0 |
No bFGF |
0 |
0 |
0 |
0 |
EGF |
2 |
1 |
5 |
3 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
bFGF |
0 |
No bFGF |
0 |
0.29 |
1 |
bFGF |
0 |
EGF |
3 |
3.87 |
0.118 |
No bFGF |
0 |
EGF |
3 |
13.23 |
0.0139 |
Chicken Stereocilium Proteomics
| The chicken protein was not reproducibly detected in the chicken stereocilia. |
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1420345_at
| Age | E12 | E13 | E16 | P0 | P6 | P15 |
|---|---|---|---|---|---|---|
| Spiral ganglion | ||||||
| Replicate 1 | 35.13 | 32.7 | 45.73 | 48.04 | 83.81 | 58.76 |
| Replicate 1 Call | A | P | A | A | A | A |
| Replicate 2 | 14.1 | 57.75 | 49.83 | 38.8 | 74.05 | 71.5 |
| Replicate 2 Call | A | P | P | P | A | P |
| Replicate 3 | 42.78 | 35.06 | 36.5 | 65.15 | 66.26 | 50.92 |
| Replicate 3 Call | A | A | P | M | A | A |
| Replicate 4 | 47.67 | 43.53 | 72.81 | 49.78 | ||
| Replicate 4 Call | P | M | A | A | ||
| Mean | 30.67 | 41.84 | 44.93 | 48.88 | 74.23 | 57.74 |
| Standard Deviation | 14.85 | 13.83 | 5.87 | 11.48 | 7.24 | 10 |
| Log2 Mean | 4.79 | 5.34 | 5.48 | 5.58 | 6.21 | 5.84 |
| Log2 Standard Deviation | 0.85 | 0.45 | 0.2 | 0.32 | 0.14 | 0.24 |
| Vestibular ganglion | ||||||
| Replicate 1 | 35.64 | 59.23 | 39.97 | 72.7 | 29.83 | 52.68 |
| Replicate 1 Call | A | P | A | P | A | P |
| Replicate 2 | 37.62 | 53.15 | 52.22 | 45.71 | 50.47 | 45.81 |
| Replicate 2 Call | A | P | A | P | A | A |
| Replicate 3 | 11.34 | 76.48 | 49.06 | 57.68 | 43.94 | 58.33 |
| Replicate 3 Call | A | P | M | A | A | A |
| Mean | 28.2 | 62.95 | 47.08 | 58.7 | 41.41 | 52.27 |
| Standard Deviation | 14.63 | 12.1 | 6.36 | 13.52 | 10.55 | 6.27 |
| Log2 Mean | 4.63 | 5.96 | 5.55 | 5.85 | 5.34 | 5.7 |
| Log2 Standard Deviation | 0.98 | 0.27 | 0.2 | 0.33 | 0.39 | 0.17 |