GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description chromodomain helicase DNA binding protein 7
Synonyms Whi; Flo; Todo; Cycn; WBE1; Obt; Lda; Mt; A730019I05Rik; Gena 52; Edy; Dz; GENA 47; Cyn; GENA 60
Chromosome 4
Genetic Map Distance 3.68 cM
RefSeq Accessions NM_001033395; NM_001081417; NP_001074886
NCBI Entrez Gene 320790 at chr4:8618068-8793957 (mm9) / chr4:8690406-8868449 (mm10)
Ensembl Gene ENSMUSG00000041235
VEGA Gene OTTMUSG00000004417
MGI Gene MGI:2444748
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
A2AJK6 Chromodomain-helicase-DNA-binding protein 7 2986 0
A2AJK7 Chromodomain helicase DNA binding protein 7 (Fragment) 19 0
Pfam Domains Chromo; Pfam-B_6638; Pfam-B_16908; Chromo; SNF2_N; Helicase_C; BRK; BRK
Mouse alleles (18)
Allele Name Allele Type
Chd7tm1e(EUCOMM)Wtsi EUCOMM-projects
Chd7tm1a(EUCOMM)Wtsi EUCOMM-projects
Chd7tm2e(EUCOMM)Wtsi EUCOMM-projects
Chd7tm2a(EUCOMM)Wtsi EUCOMM-projects
Chd7Cycn Chemically induced (ENU)
Chd7Dz Chemically induced (ENU)
Chd7Edy Chemically induced (ENU)
Chd7Flo Chemically induced (ENU)
Chd7Gt(RRR136)Byg Gene trapped
Chd7Gt(S20-7E1)Sor Gene trapped
Chd7Gt(XK403)Byg Gene trapped
Chd7Lda Chemically induced (ENU)
Chd7Mt Chemically induced (ENU)
Chd7Obt Chemically induced (ENU)
Chd7tm1.1Dmm Targeted (Floxed/Frt)
Chd7tm1.2Dmm Targeted (knock-out)
Chd7Todo Chemically induced (ENU)
Chd7Whi Chemically induced (ENU)
Human Homolog CHD7 (chromodomain helicase DNA binding protein 7)
Human synonyms IS3; KAL5
Human cytoband 8q12.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000015472 (CHD7_CHICK) encoding ENSGALP00000005893
ENSGALG00000015472 (CHD7_CHICK) encoding ENSGALP00000024904
Gene Ontology
Biological Process (36) skeletal system development; locomotory behavior; central nervous system development; cranial nerve development; T cell differentiation; genitalia development; cognition; retina development in camera-type eye; regulation of growth hormone secretion; limb development; face development; artery morphogenesis; semicircular canal morphogenesis; adult walking behavior; heart morphogenesis; heart morphogenesis; female genitalia development; camera-type eye development; blood vessel development; blood circulation; adult heart development; nose development; nose development; embryonic hindlimb morphogenesis; palate development; palate development; positive regulation of multicellular organism growth; in utero embryonic development; in utero embryonic development; sensory perception of sound; ear morphogenesis; inner ear morphogenesis; inner ear morphogenesis; regulation of transcription; DNA-dependent; chromatin modification; transcription; DNA-dependent
Cellular Component (1) nucleus
Molecular Function (10) hydrolase activity; nucleotide binding; DNA binding; DNA binding; helicase activity; helicase activity; ATP binding; ATP binding; hydrolase activity; acting on acid anhydrides; nucleic acid binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
99
76
119
176
135
98
Cochlea GFP+ cells
215
64
135
105
60
NA
Utricle GFP- cells
133
35
50
84
98
157
Cochlea GFP- cells
155
48
82
99
67
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
92
GFP+
117
1.27
0.878
Utricle
105
Cochlea
103
0.98
1
Embryonic
103
Postnatal
105
1.01
0.999
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17411647 59.80 ± 6.05 44.65 ± 8.45 [30.73] 0.75 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
9838
9977
10083
7677
No bFGF
12053
12261
12625
10279
EGF
6902
6666
6514
6694
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
7677
No bFGF
10279
1.34
1
bFGF
7677
EGF
6694
0.87
0.203
No bFGF
10279
EGF
6694
0.65
4.47e-6
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000024904
Symbol CHD7
Description Chromodomain helicase DNA binding protein 7
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -6.13 ± 0.26
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1437745_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 3015.03 687.34 1160.09 720.81 331.81 1001.16
Replicate 1 Call P P P P A P
Replicate 2 3017.17 1265.67 2061.02 547.52 511.21 487.51
Replicate 2 Call P P P P P A
Replicate 3 3226.68 1605.11 1556.05 605.55 295.48 413.36
Replicate 3 Call P P P P P A
Replicate 4 2530.98 451.39 629.46 582.94
Replicate 4 Call P P P P
Mean 3086.29 1186.04 1827.04 581.32 441.99 621.24
Standard Deviation 121.58 464.04 596.81 112.65 156.57 262.62
Log2 Mean 11.59 10.13 10.77 9.16 8.72 9.19
Log2 Standard Deviation 0.06 0.63 0.49 0.28 0.51 0.55
 
Vestibular ganglion
Replicate 1 1930.41 1128.07 168.63 62.38 37.66 128.44
Replicate 1 Call P P A A A A
Replicate 2 2014.02 1310.79 326.48 68.92 181.59 85.99
Replicate 2 Call P P A A A A
Replicate 3 1936.4 1132.03 64.96 189.88 64.45 81.18
Replicate 3 Call P P A A A A
Mean 1960.28 1190.3 186.69 107.06 94.57 98.54
Standard Deviation 46.64 104.37 131.69 71.8 76.55 26.01
Log2 Mean 10.94 10.21 7.26 6.55 6.25 6.59
Log2 Standard Deviation 0.03 0.12 1.17 0.89 1.15 0.36
Probe set ID: 1448026_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1891.9 1349.84 1085.71 685.44 207.78 568.57
Replicate 1 Call P P P P A M
Replicate 2 1986.57 1756.57 996.69 390.82 337.01 265.01
Replicate 2 Call P P P A A A
Replicate 3 1883.83 1753.11 951.08 847.73 234.54 351.43
Replicate 3 Call P P P P A A
Replicate 4 910.45 798.58 191.03 327.51
Replicate 4 Call P P A A
Mean 1920.77 1619.84 985.98 680.64 242.59 378.13
Standard Deviation 57.13 233.83 75.24 204.82 65.45 132.08
Log2 Mean 10.91 10.65 9.94 9.35 7.89 8.5
Log2 Standard Deviation 0.04 0.22 0.11 0.51 0.36 0.47
 
Vestibular ganglion
Replicate 1 837.59 1263.53 252.23 234.62 137.47 302.31
Replicate 1 Call P P A A A A
Replicate 2 1002.3 1170.25 392.22 175.86 246.77 340.72
Replicate 2 Call P P A A A A
Replicate 3 928.26 1123.5 380.09 349.6 333.68 308.79
Replicate 3 Call P P A A A A
Mean 922.72 1185.76 341.51 253.36 239.31 317.27
Standard Deviation 82.49 71.29 77.56 88.37 98.32 20.56
Log2 Mean 9.85 10.21 8.39 7.93 7.81 8.31
Log2 Standard Deviation 0.13 0.09 0.36 0.5 0.65 0.09
Probe set ID: 1457954_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 191.22 166.53 80.25 56.96 60.39 122.06
Replicate 1 Call P P P A A P
Replicate 2 199.03 232.73 147.96 37.64 70.2 51.24
Replicate 2 Call P P P A A A
Replicate 3 204.73 248.24 148.89 76.62 65.89 96.04
Replicate 3 Call P P P A P P
Replicate 4 121.36 60.75 59.13 58.05
Replicate 4 Call P A A M
Mean 198.33 215.83 124.62 57.99 63.9 81.85
Standard Deviation 6.78 43.4 32.21 16.02 5.12 33.27
Log2 Mean 7.63 7.73 6.92 5.81 5.99 6.26
Log2 Standard Deviation 0.05 0.31 0.42 0.43 0.11 0.59
 
Vestibular ganglion
Replicate 1 97.37 105.55 35.63 60.45 20.73 54.2
Replicate 1 Call M P A A A P
Replicate 2 86.82 85.78 39.22 42.74 49.32 68.06
Replicate 2 Call P A A A A A
Replicate 3 92.45 88.48 36.85 24.48 42.15 41.92
Replicate 3 Call A P A A A P
Mean 92.21 93.27 37.23 42.56 37.4 54.73
Standard Deviation 5.28 10.72 1.83 17.99 14.88 13.08
Log2 Mean 6.53 6.54 5.22 5.32 5.13 5.75
Log2 Standard Deviation 0.08 0.16 0.07 0.66 0.67 0.35