GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms D-LTCC; C79217; Cchl1a2; Cchl1a; Cacnl1a2; 8430418G19Rik; Cav1.3alpha1
Chromosome 14
Genetic Map Distance 18.43 cM
RefSeq Accessions NM_001083616; NM_028981; NP_001077085; NP_083257
NCBI Entrez Gene 12289 at chr14:30853125-31304342 (mm9) / chr14:30039939-30491156 (mm10)
Ensembl Gene ENSMUSG00000015968
VEGA Gene
MGI Gene MGI:88293
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q99246 Voltage-dependent L-type calcium channel subunit alpha-1D 2179 19
Q6PDD2 Cacna1d protein 859 2
Q9CRQ8 Putative uncharacterized protein (Fragment) 134 0
Pfam Domains Ion_trans; Ion_trans; PGA2; Ion_trans; Ion_trans; Ca_chan_IQ
Mouse alleles (5)
Allele Name Allele Type
Cacna1dtm1a(EUCOMM)Hmgu EUCOMM-projects
Cacna1dtm1e(EUCOMM)Hmgu EUCOMM-projects
Cacna1dGt(OST116380)Lex Gene trapped
Cacna1dtm1Hssh Targeted (knock-out)
Cacna1dtm1Jst Targeted (knock-out)
Human Homolog CACNA1D (calcium channel, voltage-dependent, L type, alpha 1D subunit)
Human synonyms CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2
Human cytoband 3p14.3
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (3)
ENSGALG00000005332 (CAC1D_CHICK) encoding ENSGALP00000008540
ENSGALG00000005332 (CAC1D_CHICK) encoding ENSGALP00000021217
ENSGALG00000005332 (CAC1D_CHICK) encoding ENSGALP00000035486
Gene Ontology
Biological Process (13) calcium ion transport; sensory perception of sound; regulation of calcium ion transport via voltage-gated calcium channel activity; calcium-mediated signaling; G-protein signaling; coupled to cAMP nucleotide second messenger; transmembrane transport; regulation of ion transmembrane transport; calcium ion transmembrane transport; calcium ion transmembrane transport; calcium ion transmembrane transport; transport; ion transport; ion transport
Cellular Component (11) plasma membrane; intracellular; intracellular; apical plasma membrane; voltage-gated calcium channel complex; voltage-gated calcium channel complex; integral to plasma membrane; integral to membrane; integral to membrane; membrane; membrane
Molecular Function (8) voltage-gated ion channel activity; ion channel activity; ion channel activity; protein binding; high voltage-gated calcium channel activity; calcium channel activity; voltage-gated calcium channel activity; voltage-gated calcium channel activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
3752
45
415
281
206
536
Cochlea GFP+ cells
33
32
277
462
642
NA
Utricle GFP- cells
10
44
22
17
69
15
Cochlea GFP- cells
5
6
115
56
50
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
37
GFP+
607
16.16
9.79e-5
Utricle
451
Cochlea
168
0.37
1
Embryonic
491
Postnatal
226
0.46
0.346
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17304353 141.57 ± 7.99 502.18 ± 57.85 [430.82] 3.55 0.0753
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1
1
1
1
No bFGF
7
7
9
6
EGF
28
24
27
26
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1
No bFGF
6
6.34
0.327
bFGF
1
EGF
26
25.03
1.84e-9
No bFGF
6
EGF
26
3.95
5.27e-5
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1427974_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 233.09 626.94 2612.85 3881.2 1396.98 823.01
Replicate 1 Call P P P P P P
Replicate 2 237.47 560.42 3185.02 2150.78 2685.54 865.74
Replicate 2 Call P P P P P P
Replicate 3 244.06 559.53 2718.52 4221.23 892.22 1347.21
Replicate 3 Call P P P P P P
Replicate 4 2519.94 3401.04 654.7 1302.99
Replicate 4 Call P P P P
Mean 238.21 582.3 2759.08 3413.56 1407.36 1084.74
Standard Deviation 5.52 38.66 295.32 906.6 906.59 278.68
Log2 Mean 7.9 9.18 11.42 11.69 10.25 10.05
Log2 Standard Deviation 0.03 0.09 0.15 0.43 0.88 0.38
 
Vestibular ganglion
Replicate 1 602.07 1258.92 751.22 873.34 676.23 676.33
Replicate 1 Call P P P P P P
Replicate 2 602.44 1151.71 1089.15 693.57 938.69 530.65
Replicate 2 Call P P P P P P
Replicate 3 562.77 1326.38 758.33 888.81 1070.41 564.04
Replicate 3 Call P P P P P P
Mean 589.09 1245.67 866.23 818.57 895.11 590.34
Standard Deviation 22.8 88.09 193.08 108.53 200.67 76.32
Log2 Mean 9.2 10.28 9.74 9.67 9.78 9.2
Log2 Standard Deviation 0.06 0.1 0.31 0.2 0.34 0.18
Probe set ID: 1428051_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 196.76 294.51 271.62 231.44 227.13 199.81
Replicate 1 Call A A A A A A
Replicate 2 193.65 314.62 335.92 241.45 229.4 248.78
Replicate 2 Call A A A A A A
Replicate 3 169.46 340.52 290.67 249.7 218.46 246.32
Replicate 3 Call A A A A A A
Replicate 4 230.68 245.1 256.03 346.9
Replicate 4 Call A A A A
Mean 186.62 316.55 282.22 241.92 232.76 260.45
Standard Deviation 14.95 23.07 43.68 7.76 16.22 61.88
Log2 Mean 7.54 8.3 8.13 7.92 7.86 8
Log2 Standard Deviation 0.12 0.1 0.23 0.05 0.1 0.33
 
Vestibular ganglion
Replicate 1 247.67 257.44 191.58 178.16 204.54 400.31
Replicate 1 Call A A A A A P
Replicate 2 210.39 311.21 228.09 221.43 227.52 307.94
Replicate 2 Call A P A A A P
Replicate 3 180.74 281.08 200.06 259.55 210.37 287.42
Replicate 3 Call A P A A A P
Mean 212.93 283.24 206.58 219.71 214.14 331.89
Standard Deviation 33.54 26.95 19.11 40.72 11.95 60.14
Log2 Mean 7.72 8.14 7.69 7.76 7.74 8.36
Log2 Standard Deviation 0.23 0.14 0.13 0.27 0.08 0.25
Probe set ID: 1455435_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 107.36 101.14 201.4 254.47 841.94 409.48
Replicate 1 Call A P P P P P
Replicate 2 87.37 87.75 465.4 155.95 533.67 474.44
Replicate 2 Call A P P P P P
Replicate 3 92.79 84.9 415.59 699.97 820.68 903.76
Replicate 3 Call A P P P P P
Replicate 4 601.14 300.56 527.51 952.58
Replicate 4 Call P P P P
Mean 95.84 91.26 420.88 352.74 680.95 685.07
Standard Deviation 10.34 8.67 166.01 239.22 173.86 282.67
Log2 Mean 6.58 6.51 8.61 8.24 9.38 9.32
Log2 Standard Deviation 0.15 0.13 0.68 0.9 0.37 0.63
 
Vestibular ganglion
Replicate 1 128.56 114.65 135.85 178.41 539.34 935.51
Replicate 1 Call A P M M P P
Replicate 2 92.98 119.55 132.84 114.41 598.66 864.68
Replicate 2 Call A P A A P P
Replicate 3 117.23 106.12 289.01 153.83 340.07 878.64
Replicate 3 Call A P P A P P
Mean 112.92 113.44 185.9 148.88 492.69 892.94
Standard Deviation 18.18 6.8 89.31 32.29 135.46 37.52
Log2 Mean 6.81 6.82 7.44 7.19 8.9 9.8
Log2 Standard Deviation 0.24 0.09 0.64 0.33 0.43 0.06