GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATPase, Ca++ transporting, plasma membrane 2
Synonyms Gena300; Tmy; jog; D6Abb2e; PMCA2; wms
Chromosome 6
Genetic Map Distance 52.85 cM
RefSeq Accessions NM_001036684; NM_009723; NP_001031761; NP_033853
NCBI Entrez Gene 11941 at chr6:113695662-113992020 (mm9) / chr6:113745668-113980591 (mm10)
Ensembl Gene ENSMUSG00000030302
VEGA Gene OTTMUSG00000018967
MGI Gene MGI:105368
Mouse Protein (5)
UniProt ID Description Length (AA) Predicted # TMs
Q9R0K7 Plasma membrane calcium-transporting ATPase 2 1198 8
D3Z0Z7 Uncharacterized protein 1243 8
Q3UHH0 Putative uncharacterized protein 1194 8
Q3UHJ3 ATPase, Ca++ transporting, plasma membrane 2, isoform CRA_a 1198 8
Q6DIB8 Atp2b2 protein 634 4
Pfam Domains Cation_ATPase_N; E1-E2_ATPase; Hydrolase; Hydrolase; Cation_ATPase_C; ATP_Ca_trans_C
Mouse alleles (11)
Allele Name Allele Type
Atp2b2tm1a(EUCOMM)Wtsi EUCOMM-projects
Atp2b2tm1e(EUCOMM)Wtsi EUCOMM-projects
Atp2b2dfw-2J Spontaneous
Atp2b2dfw-3J Spontaneous
Atp2b2dfw Spontaneous
Atp2b2jog Spontaneous
Atp2b2m1Mae Spontaneous
Atp2b2Obv Chemically induced (ENU)
Atp2b2tm1Ges Targeted (knock-out)
Atp2b2Tmy Chemically induced (ENU)
Atp2b2wri Spontaneous
Human Homolog ATP2B2 (ATPase, Ca++ transporting, plasma membrane 2)
Human synonyms PMCA2; PMCA2a; PMCA2i
Human cytoband 3p25.3
Known deafness gene DFNB12
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000004829 (ATP2B2) encoding ENSGALP00000005687
ENSGALG00000004829 (ATP2B2) encoding ENSGALP00000007703
Gene Ontology
Biological Process (58) synapse organization; locomotory behavior; cGMP metabolic process; locomotory behavior; cGMP metabolic process; locomotory behavior; serotonin metabolic process; locomotory behavior; neuromuscular process controlling balance; locomotory behavior; neuromuscular process controlling balance; neuromuscular process controlling balance; lactation; cation transport; locomotory behavior; inner ear morphogenesis; transport; otolith mineralization; ATP biosynthetic process; cell morphogenesis; calcium ion transport; calcium ion transport; calcium ion transport; cellular calcium ion homeostasis; sensory perception of sound; detection of mechanical stimulus involved in sensory perception of sound; neuron differentiation; ATP catabolic process; ATP catabolic process; ATP catabolic process; cytosolic calcium ion homeostasis; cytosolic calcium ion homeostasis; sensory perception of sound; regulation of cell size; sensory perception of sound; locomotion; sensory perception of sound; sensory perception of sound; sensory perception of sound; sensory perception of sound; sensory perception of sound; cerebellum development; cellular calcium ion homeostasis; cerebellar Purkinje cell differentiation; sensory perception of sound; cerebellar granule cell differentiation; sensory perception of sound; organelle organization; regulation of synaptic plasticity; ion transport; calcium ion transmembrane transport; calcium ion transmembrane transport; cochlea development; inner ear receptor cell differentiation; auditory receptor cell stereocilium organization; inner ear development; cerebellar Purkinje cell layer morphogenesis; positive regulation of calcium ion transport
Cellular Component (15) cilium; microsome; membrane; membrane; integral to membrane; neuronal cell body; neuronal cell body; dendrite; cytoplasm; endoplasmic reticulum; plasma membrane; plasma membrane; membrane raft; apical plasma membrane; apical plasma membrane
Molecular Function (18) calcium-dependent ATPase activity; hydrolase activity; metal ion binding; metal ion binding; nucleotide binding; nucleotide binding; calcium-transporting ATPase activity; calcium-transporting ATPase activity; calcium ion binding; hydrolase activity; acting on acid anhydrides; catalyzing transmembrane movement of substances; ATPase activity; coupled to transmembrane movement of ions; phosphorylative mechanism; calmodulin binding; ATP binding; ATP binding; glutamate receptor binding; protein C-terminus binding; PDZ domain binding; PDZ domain binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
1119
1604
3934
11990
20943
24467
Cochlea GFP+ cells
2348
440
5520
8946
13652
NA
Utricle GFP- cells
121
226
5
19
162
1998
Cochlea GFP- cells
101
97
33
204
413
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
307
GFP+
8633
28.05
1.61e-9
Utricle
5549
Cochlea
3176
0.57
1
Embryonic
757
Postnatal
6592
8.70
4.99e-5
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17469814 29.64 ± 2.38 126.59 ± 20.00 [148.56] 4.27 0.0958
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
22
9
16
12
No bFGF
45
43
47
34
EGF
1505
1393
1600
1499
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
12
No bFGF
34
2.68
0.994
bFGF
12
EGF
1499
117.50
4.48e-69
No bFGF
34
EGF
1499
43.92
6.98e-81
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000005687
Symbol ATP2B2
Description ATPase, Ca++ transporting, plasma membrane 2
log10 riBAQ in stereocilia (mean ± sd) -2.94 ± 0.05
log10 riBAQ in utricle (mean ± sd) -2.94 ± 0.08
Molecules per stereocilium (mean ± error with slope error) 1682.24 ± 58.33
Corrected Molecules per stereocilium (mean ± sd) 1387.74 ± 476.41
Stereocilium / Utricle ratio (mean ± sd) 1.01 ± 0.05
Enriched in the stereocilia (FDR < 0.05) TRUE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1420402_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 98.33 46.85 124.14 77.28 203.28 95.72
Replicate 1 Call A A P A M A
Replicate 2 92.02 49.73 318.09 50.56 442.38 57.02
Replicate 2 Call A A P A P A
Replicate 3 62.66 53.41 361.8 130.14 36.29 262.03
Replicate 3 Call A A P A A M
Replicate 4 391.12 99.87 41.84 292.29
Replicate 4 Call P A A P
Mean 84.34 50 298.79 89.46 180.95 176.77
Standard Deviation 19.04 3.29 120.24 33.79 190.72 117.65
Log2 Mean 6.37 5.64 8.09 6.4 6.76 7.16
Log2 Standard Deviation 0.35 0.09 0.77 0.58 1.76 1.14
 
Vestibular ganglion
Replicate 1 144.15 81.41 68.92 60.26 89.83 74.42
Replicate 1 Call A A A A A A
Replicate 2 144.21 71.77 67.97 55 74.28 100.35
Replicate 2 Call A A A A A A
Replicate 3 137.13 68.64 57.03 52.74 71.19 67.12
Replicate 3 Call A A A A A A
Mean 141.83 73.94 64.64 56 78.43 80.63
Standard Deviation 4.07 6.66 6.61 3.86 9.99 17.46
Log2 Mean 7.15 6.2 6.01 5.81 6.29 6.31
Log2 Standard Deviation 0.04 0.13 0.15 0.1 0.18 0.3
Probe set ID: 1420403_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 185.9 190.08 202.77 333.16 343.22 107.34
Replicate 1 Call A A A A A A
Replicate 2 152.78 187.5 303.28 93.79 641.87 43.34
Replicate 2 Call A A A A A A
Replicate 3 188.55 183.1 248.64 442.69 54.01 581.71
Replicate 3 Call A A A A A A
Replicate 4 159.69 367.09 54.14 828.47
Replicate 4 Call A A A P
Mean 175.74 186.89 228.6 309.18 273.31 390.22
Standard Deviation 19.93 3.53 61.63 150.72 280.98 378.19
Log2 Mean 7.45 7.55 7.8 8.06 7.32 7.77
Log2 Standard Deviation 0.17 0.03 0.4 1.02 1.84 2.02
 
Vestibular ganglion
Replicate 1 142.98 188.94 70.09 73.44 96.88 264.04
Replicate 1 Call A A A A A A
Replicate 2 201.71 167.43 119.14 106.72 80.62 334.36
Replicate 2 Call A A A A A A
Replicate 3 159.09 183.38 63.8 167.56 110.16 204.4
Replicate 3 Call A A A A A A
Mean 167.93 179.92 84.34 115.91 95.89 267.6
Standard Deviation 30.35 11.17 30.3 47.73 14.8 65.05
Log2 Mean 7.38 7.49 6.34 6.77 6.57 8.04
Log2 Standard Deviation 0.25 0.09 0.49 0.6 0.23 0.36
Probe set ID: 1433888_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 2727.88 2254.49 3581.03 4024.9 4252.13 2090.43
Replicate 1 Call P P P P P P
Replicate 2 2812.95 2740.82 3817.5 2387.42 5974.93 1217.26
Replicate 2 Call P P P P P P
Replicate 3 2801.33 2788.83 3790.11 4974.61 937.83 4605.55
Replicate 3 Call P P P P P P
Replicate 4 3498.73 4327.58 143.95 5074.2
Replicate 4 Call P P P P
Mean 2780.72 2594.71 3671.84 3928.63 2827.21 3246.86
Standard Deviation 46.13 295.62 156.44 1101.19 2751.25 1883.42
Log2 Mean 11.44 11.33 11.84 11.89 10.41 11.44
Log2 Standard Deviation 0.02 0.17 0.06 0.46 2.45 0.98
 
Vestibular ganglion
Replicate 1 3824.02 4186.79 2071.16 2090.95 2125.75 3484.74
Replicate 1 Call P P P P P P
Replicate 2 3895.14 4204.76 2619.38 2016.32 2038.63 3530.33
Replicate 2 Call P P P P P P
Replicate 3 3905.97 4160.33 1616.2 2464.52 2167.65 3322.26
Replicate 3 Call P P P P P P
Mean 3875.04 4183.96 2102.25 2190.6 2110.68 3445.78
Standard Deviation 44.52 22.35 502.31 240.14 65.82 109.37
Log2 Mean 11.92 12.03 11.01 11.09 11.04 11.75
Log2 Standard Deviation 0.02 0.01 0.35 0.15 0.05 0.05