GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description atonal homolog 1 (Drosophila)
Synonyms bHLHa14; Math1; Hath1
Chromosome 6
Genetic Map Distance 30.03 cM
RefSeq Accessions NM_007500; NP_031526
NCBI Entrez Gene 11921 at chr6:64679140-64681237 (mm9) / chr6:64729146-64731243 (mm10)
Ensembl Gene ENSMUSG00000073043
VEGA Gene
MGI Gene MGI:104654
Mouse Protein (1)
UniProt ID Description Length (AA) Predicted # TMs
P48985 Protein atonal homolog 1 351 0
Pfam Domains HLH
Mouse alleles (9)
Allele Name Allele Type
Atoh1tm1(cre)Gan Targeted (knock-in)
Atoh1tm1(cre/ERT2)Mhos Targeted (knock-in)
Atoh1tm1Hzo Targeted (knock-out)
Atoh1tm2Hzo Targeted (Reporter)
Atoh1tm3.1Hzo Targeted (knock-out)
Atoh1tm3Hzo Targeted (Floxed/Frt)
Atoh1tm4.1Hzo Targeted (Reporter)
Atoh1tm5.1(cre/PGR)Hzo Targeted (knock-in)
Atoh1tm6.1Hzo Targeted (knock-in)
Human Homolog ATOH1 (atonal homolog 1 (Drosophila))
Human synonyms ATH1; bHLHa14; HATH1; MATH-1
Human cytoband 4q22
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (2)
ENSGALG00000010398 (Q800U5_CHICK) encoding ENSGALP00000037551
ENSGALG00000010398 (Q800U5_CHICK) encoding ENSGALP00000037553
Gene Ontology
Biological Process (28) auditory receptor cell differentiation; multicellular organismal development; nervous system development; transcription; DNA-dependent; positive regulation of auditory receptor cell differentiation; positive regulation of auditory receptor cell differentiation; auditory receptor cell fate specification; positive regulation of inner ear receptor cell differentiation; positive regulation of inner ear receptor cell differentiation; inner ear development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cerebral cortex development; inner ear morphogenesis; inner ear morphogenesis; regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; auditory receptor cell fate determination; neuron migration; cell differentiation; axon guidance; neuron differentiation; brain development; auditory receptor cell differentiation; auditory receptor cell differentiation; regulation of transcription; DNA-dependent; apoptotic process
Cellular Component (1) nucleus
Molecular Function (4) sequence-specific DNA binding; chromatin DNA binding; protein binding; DNA binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
5500
1164
1364
600
395
346
Cochlea GFP+ cells
283
690
1386
400
141
NA
Utricle GFP- cells
1
81
9
1
12
141
Cochlea GFP- cells
0
21
23
2
1
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
26
GFP+
1115
41.37
5.19e-14
Utricle
801
Cochlea
295
0.37
1
Embryonic
967
Postnatal
344
0.36
0.912
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17459153 13.95 ± 0.34 13.73 ± 1.04 [14.15] 0.98 0.882
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1
2
2
1
No bFGF
2
4
1
2
EGF
55
53
64
57
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1
No bFGF
2
1.46
1
bFGF
1
EGF
57
35.19
1.42e-14
No bFGF
2
EGF
57
24.14
3.3e-16
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1449822_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 81.14 73.58 86.38 78.41 81.6 84.35
Replicate 1 Call A A P A A A
Replicate 2 90.08 75.82 93.75 90.53 70.35 98.5
Replicate 2 Call A A P A A A
Replicate 3 69.15 80.77 77.61 98.84 68.9 106.43
Replicate 3 Call A A A A A A
Replicate 4 111.08 92.46 67.74 83.04
Replicate 4 Call P A A A
Mean 80.12 76.72 92.21 90.06 72.15 93.08
Standard Deviation 10.5 3.68 14.21 8.54 6.39 11.32
Log2 Mean 6.32 6.26 6.51 6.49 6.17 6.53
Log2 Standard Deviation 0.19 0.07 0.22 0.14 0.12 0.17
 
Vestibular ganglion
Replicate 1 81.28 75.6 86.07 577.2 96.82 110.44
Replicate 1 Call A A A P A A
Replicate 2 78.3 97.24 741.36 98.47 314.54 54.26
Replicate 2 Call A P P A P A
Replicate 3 93.7 87.15 2888.74 643.15 668.17 80.02
Replicate 3 Call A A P P P A
Mean 84.43 86.66 1238.72 439.61 359.84 81.57
Standard Deviation 8.17 10.83 1466.04 297.27 288.36 28.12
Log2 Mean 6.4 6.43 9.15 8.37 8.09 6.29
Log2 Standard Deviation 0.14 0.18 2.56 1.52 1.4 0.51