GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ADP-ribosylation factor 4
Synonyms
Chromosome 14
Genetic Map Distance 16.09 cM
RefSeq Accessions NM_007479; NP_031505
NCBI Entrez Gene 11843 at chr14:27457683-27476744 (mm9) / chr14:26638197-26657258 (mm10)
Ensembl Gene ENSMUSG00000021877
VEGA Gene OTTMUSG00000035433
MGI Gene MGI:99433
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
P61750 ADP-ribosylation factor 4 180 0
Q14BR4 ADP-ribosylation factor 4 180 0
Q9DD04 Putative uncharacterized protein 181 0
Pfam Domains Arf
Mouse alleles (2)
Allele Name Allele Type
Arf4tm1a(KOMP)Wtsi KOMP-CSD-Project
Arf4tm1e(KOMP)Wtsi KOMP-CSD-Project
Human Homolog ARF4 (ADP-ribosylation factor 4)
Human synonyms ARF2
Human cytoband 3p21.2-p21.1
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000005622 (ARF5_CHICK) encoding ENSGALP00000009007
Gene Ontology
Biological Process (5) epidermal growth factor receptor signaling pathway; transport; vesicle-mediated transport; protein transport; small GTPase mediated signal transduction
Cellular Component (4) Golgi apparatus; cytoplasm; plasma membrane; intracellular
Molecular Function (2) nucleotide binding; GTP binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
815
1516
1520
473
312
366
Cochlea GFP+ cells
1099
1494
850
465
298
NA
Utricle GFP- cells
1590
1992
3068
2267
1581
1919
Cochlea GFP- cells
1496
2102
7633
1652
1523
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
2439
GFP+
837
0.34
0.458
Utricle
1452
Cochlea
1861
1.28
1
Embryonic
1513
Postnatal
1709
1.13
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17297913 65.70 ± 0.80 56.07 ± 7.69 [65.13] 0.85 0.516
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1844
1589
1715
1988
No bFGF
1423
1387
1436
1683
EGF
2124
2147
2384
2218
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1988
No bFGF
1683
0.85
1
bFGF
1988
EGF
2218
1.12
0.388
No bFGF
1683
EGF
2218
1.32
0.0153
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000009007
Symbol ARF4
Description ADP-ribosylation factor 4
log10 riBAQ in stereocilia (mean ± sd) -2.21 ± 0.10
log10 riBAQ in utricle (mean ± sd) -2.25 ± 0.09
Molecules per stereocilium (mean ± error with slope error) 9071.46 ± 487.26
Corrected Molecules per stereocilium (mean ± sd) 7615.91 ± 2581.20
Stereocilium / Utricle ratio (mean ± sd) 1.08 ± 0.08
Enriched in the stereocilia (FDR < 0.05) TRUE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1423052_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 4314.7 2927.03 2942.56 2673.25 2880.44 2922.01
Replicate 1 Call P P P P P P
Replicate 2 4207.95 3075.62 2636.2 3078.09 2645.98 2879.88
Replicate 2 Call P P P P P P
Replicate 3 4364.73 3154.19 2939.82 2364.03 3043.37 2473.84
Replicate 3 Call P P P P P P
Replicate 4 2602.47 2555.32 3214.63 2423.7
Replicate 4 Call P P P P
Mean 4295.79 3052.28 2780.26 2667.67 2946.11 2674.86
Standard Deviation 80.08 115.36 186.34 301.83 242.18 262.43
Log2 Mean 12.07 11.57 11.44 11.37 11.52 11.38
Log2 Standard Deviation 0.03 0.05 0.1 0.16 0.12 0.14
 
Vestibular ganglion
Replicate 1 4595.11 2972.62 2904.33 2263.71 2027.39 2140.93
Replicate 1 Call P P P P P P
Replicate 2 4468.06 3306.91 3024.58 2367.63 2670.01 2072.58
Replicate 2 Call P P P P P P
Replicate 3 4612.42 2833.19 2224.6 2152.1 2957.28 2026.64
Replicate 3 Call P P P P P P
Mean 4558.53 3037.57 2717.84 2261.15 2551.56 2080.05
Standard Deviation 78.83 243.45 431.37 107.79 476.13 57.51
Log2 Mean 12.15 11.57 11.4 11.14 11.3 11.02
Log2 Standard Deviation 0.03 0.11 0.24 0.07 0.28 0.04
Probe set ID: 1423053_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 166.57 108.55 74.89 61.65 112.74 101.19
Replicate 1 Call A P A A A A
Replicate 2 175.99 178.28 80.15 84.58 93.24 79.71
Replicate 2 Call A P A A A A
Replicate 3 143.99 174.02 93.2 73.3 91.19 49.14
Replicate 3 Call A P A A A A
Replicate 4 97.02 71.94 98.59 41.22
Replicate 4 Call A A A A
Mean 162.18 153.62 86.32 72.87 98.94 67.82
Standard Deviation 16.44 39.09 10.5 9.38 9.71 27.76
Log2 Mean 7.34 7.23 6.42 6.18 6.62 5.99
Log2 Standard Deviation 0.15 0.4 0.18 0.19 0.14 0.6
 
Vestibular ganglion
Replicate 1 112.21 93.17 75.63 45.55 79.67 59.15
Replicate 1 Call A P A A A A
Replicate 2 121.09 109.56 98.3 77.17 71.72 97.1
Replicate 2 Call A P A A A A
Replicate 3 149.34 102.36 91.77 61.73 94.18 111.45
Replicate 3 Call A A A A A A
Mean 127.55 101.7 88.57 61.48 81.86 89.23
Standard Deviation 19.39 8.22 11.67 15.81 11.39 27.02
Log2 Mean 6.98 6.66 6.46 5.91 6.35 6.43
Log2 Standard Deviation 0.21 0.12 0.2 0.38 0.2 0.48
Probe set ID: 1434074_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 12.63 16.56 21.31 13.4 4.47 9.38
Replicate 1 Call A P A A A A
Replicate 2 2.08 12.61 38.45 21.46 15.72 10.86
Replicate 2 Call A A A A A A
Replicate 3 21.25 27.43 32.83 17.13 3.64 19.19
Replicate 3 Call A A A P A A
Replicate 4 34.2 13.91 2.73 21.44
Replicate 4 Call A A A A
Mean 11.99 18.87 31.7 16.48 6.64 15.22
Standard Deviation 9.6 7.67 7.33 3.71 6.09 5.99
Log2 Mean 3.04 4.16 4.95 4.02 2.36 3.84
Log2 Standard Deviation 1.76 0.57 0.37 0.31 1.11 0.59
 
Vestibular ganglion
Replicate 1 22.81 19.18 20.49 16.51 16.21 10.65
Replicate 1 Call A P A A A A
Replicate 2 12.15 32.98 29.68 23.23 12.88 20.84
Replicate 2 Call A A A A A P
Replicate 3 4.69 21.25 4.07 23.15 36.86 18.3
Replicate 3 Call A P A A A A
Mean 13.22 24.47 18.08 20.96 21.98 16.6
Standard Deviation 9.11 7.44 12.97 3.86 12.99 5.3
Log2 Mean 3.45 4.57 3.76 4.37 4.3 4
Log2 Standard Deviation 1.15 0.42 1.52 0.28 0.8 0.51