GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description apolipoprotein E
Synonyms
Chromosome 7
Genetic Map Distance 9.94 cM
RefSeq Accessions NM_009696; NP_033826
NCBI Entrez Gene 11816 at chr7:20281593-20284515 (mm9) / chr7:19696244-19699166 (mm10)
Ensembl Gene ENSMUSG00000002985
VEGA Gene OTTMUSG00000038239
MGI Gene MGI:88057
Mouse Protein (9)
UniProt ID Description Length (AA) Predicted # TMs
P08226 Apolipoprotein E 311 0
Q3TX45 Putative uncharacterized protein 311 0
Q3TXU4 Apolipoprotein E, isoform CRA_h 311 0
Q3UBS0 Putative uncharacterized protein 311 0
Q3UEE7 Putative uncharacterized protein 311 0
Q3UF21 Putative uncharacterized protein (Fragment) 158 0
Q4FK40 Apoe protein 311 0
Q6GTX3 Apoe protein 311 0
Q8C6E4 Putative uncharacterized protein (Fragment) 26 0
Pfam Domains Pfam-B_6360; CorA; Apo-CIII; OmpH; DUF2317; Prominin; Apolipoprotein; V-ATPase_G; DUF1043; DUF883; Pfam-B_6360; Pfam-B_119; Laminin_I; DUF883; Syntaxin; ApoLp-III; MutS_IV
Mouse alleles (17)
Allele Name Allele Type
Apoetm1e(KOMP)Wtsi KOMP-CSD-Project
Apoetm1a(KOMP)Wtsi KOMP-CSD-Project
Apoetm1e(KOMP)Mbp KOMP-CSD-Project
Apoeshl Spontaneous
Apoetm1(APOE)Kyan Targeted (knock-in)
Apoetm1(APOE)Sfu Targeted (knock-in)
Apoetm1(APOE*2)Mae Targeted (knock-in)
Apoetm1.1Khw Targeted (knock-in)
Apoetm1Bres Targeted (knock-out)
Apoetm1Khw Targeted (knock-in)
Apoetm1Lmh Targeted (knock-out)
Apoetm1Unc Targeted (knock-out)
Apoetm1Yhg Targeted (Reporter)
Apoetm2(APOE)Sfu Targeted (knock-in)
Apoetm2(APOE*3)Mae Targeted (knock-in)
Apoetm3(APOE*4)Mae Targeted (knock-in)
Apoetm4Mae Targeted (knock-out)
Human Homolog APOE (apolipoprotein E)
Human synonyms AD2; LDLCQ5; LPG
Human cytoband 19q13.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (0)
Gene Ontology
Biological Process (66) very-low-density lipoprotein particle remodeling; very-low-density lipoprotein particle remodeling; aging; high-density lipoprotein particle remodeling; triglyceride metabolic process; high-density lipoprotein particle assembly; anti-apoptosis; chylomicron remnant clearance; induction of apoptosis; cholesterol metabolic process; G-protein coupled receptor signaling pathway; cholesterol metabolic process; response to oxidative stress; cholesterol metabolic process; nitric oxide mediated signal transduction; vasodilation; high-density lipoprotein particle clearance; cholesterol catabolic process; cholesterol homeostasis; cellular calcium ion homeostasis; cGMP-mediated signaling; negative regulation of blood coagulation; negative regulation of MAP kinase activity; lipoprotein metabolic process; negative regulation of blood vessel endothelial cell migration; lipoprotein metabolic process; reverse cholesterol transport; lipoprotein metabolic process; negative regulation of cholesterol biosynthetic process; lipoprotein metabolic process; protein localization; lipoprotein biosynthetic process; lipid metabolic process; lipoprotein catabolic process; positive regulation of cholesterol efflux; positive regulation of cholesterol esterification; positive regulation of cholesterol esterification; very-low-density lipoprotein particle clearance; cardiovascular system development; negative regulation of endothelial cell proliferation; receptor-mediated endocytosis; negative regulation of platelet activation; positive regulation of cGMP biosynthetic process; Cdc42 protein signal transduction; positive regulation of low-density lipoprotein particle receptor catabolic process; phospholipid efflux; transport; lipid transport; response to ethanol; artery morphogenesis; lipid homeostasis; maintenance of location in cell; regulation of gene expression; response to dietary excess; positive regulation of nitric-oxide synthase activity; axon regeneration; cholesterol homeostasis; cholesterol homeostasis; cholesterol homeostasis; cholesterol homeostasis; positive regulation of membrane protein ectodomain proteolysis; cholesterol efflux; cholesterol efflux; cholesterol efflux; low-density lipoprotein particle remodeling; negative regulation of inflammatory response
Cellular Component (22) chylomicron; cytoplasm; late endosome; Golgi apparatus; dendrite; early endosome; microtubule; extracellular space; extracellular space; extracellular space; extracellular space; extracellular space; extracellular space; extracellular region; extracellular region; very-low-density lipoprotein particle; low-density lipoprotein particle; low-density lipoprotein particle; intermediate-density lipoprotein particle; high-density lipoprotein particle; neuronal cell body; extrinsic to external side of plasma membrane
Molecular Function (19) phospholipid binding; heparin binding; lipid binding; identical protein binding; protein homodimerization activity; metal chelating activity; cholesterol transporter activity; protein heterodimerization activity; lipoprotein particle binding; antioxidant activity; very-low-density lipoprotein particle receptor binding; beta-amyloid binding; lipid transporter activity; lipid transporter activity; phospholipid binding; phosphatidylcholine-sterol O-acyltransferase activator activity; tau protein binding; low-density lipoprotein particle receptor binding; phosphatidylcholine-sterol O-acyltransferase activator activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
0
1
29
23
0
Cochlea GFP+ cells
16
22
3
69
38
NA
Utricle GFP- cells
298
89
400
3245
5475
1101
Cochlea GFP- cells
58
78
176
965
1264
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
1195
GFP+
19
0.02
8.21e-7
Utricle
889
Cochlea
269
0.30
0.784
Embryonic
71
Postnatal
913
12.85
0.0097
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17487381 54.65 ± 1.55 43.14 ± 11.82 [65.40] 0.79 0.504
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
4166
4322
6353
3724
No bFGF
7198
8304
10712
6680
EGF
5324
5542
7247
6038
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
3724
No bFGF
6680
1.79
0.929
bFGF
3724
EGF
6038
1.62
3.36e-6
No bFGF
6680
EGF
6038
0.90
0.485
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Apoe.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1432466_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 15.16 41.13 182.39 2956.99 4416.32 6037.4
Replicate 1 Call A A A P P P
Replicate 2 28.46 36.11 680.77 5178.34 4283.06 4106.5
Replicate 2 Call A A P P P P
Replicate 3 18.11 41 453.57 435.1 2868.03 4832.47
Replicate 3 Call A A P P P P
Replicate 4 1366.34 613.67 3130.8 4048.53
Replicate 4 Call P P P P
Mean 20.58 39.41 670.77 2296.03 3674.55 4756.23
Standard Deviation 6.98 2.86 506.49 2238.9 788.81 925.6
Log2 Mean 4.31 5.3 9.04 10.47 11.82 12.2
Log2 Standard Deviation 0.47 0.11 1.21 1.73 0.32 0.27
 
Vestibular ganglion
Replicate 1 28.78 101.42 248 134.03 381.87 521.15
Replicate 1 Call A P A A P P
Replicate 2 33.25 79.76 151.06 232.66 367.49 583.84
Replicate 2 Call A A A P P P
Replicate 3 25.24 96.55 58.75 533.89 834.63 763.49
Replicate 3 Call A P A P P P
Mean 29.09 92.58 152.6 300.19 528 622.83
Standard Deviation 4.01 11.36 94.63 208.31 265.65 125.79
Log2 Mean 4.85 6.52 7.02 8 8.93 9.26
Log2 Standard Deviation 0.2 0.18 1.06 1 0.67 0.28