GENE VIEW

Ank

MOUSE GENE INFORMATION [PubMed]
Description progressive ankylosis
Synonyms D15Ertd221e
Chromosome 15
Genetic Map Distance 10.23 cM
RefSeq Accessions NM_020332; NP_065065
NCBI Entrez Gene 11732 at chr15:27396432-27524664 (mm9) / chr15:27466677-27594909 (mm10)
Ensembl Gene ENSMUSG00000022265
VEGA Gene OTTMUSG00000026300
MGI Gene MGI:3045421
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q9JHZ2 Progressive ankylosis protein 492 8
Q3UG85 Progressive ankylosis 492 8
Q8C438 Putative uncharacterized protein 492 8
Pfam Domains ANKH
Mouse alleles (5)
Allele Name Allele Type
Anktm1e(KOMP)Wtsi KOMP-CSD-Project
Ankank Spontaneous
Anktm1.1Ejr Targeted (knock-in)
Anktm1.1Kng Targeted (knock-out)
Anktm1Kng Targeted (Floxed/Frt)
Human Homolog ANKH (ankylosis, progressive homolog (mouse))
Human synonyms ANK; CCAL2; CMDJ; CPPDD; HANK; MANK
Human cytoband 5p15.1
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000012964 (Q5EEJ9_CHICK) encoding ENSGALP00000004302
ENSGALG00000012964 (Q5EEJ9_CHICK) encoding ENSGALP00000021117
Gene Ontology
Biological Process (7) phosphate ion transport; transport; inorganic diphosphate transport; regulation of bone mineralization; regulation of bone mineralization; ion transmembrane transport; phosphate ion transmembrane transport
Cellular Component (5) plasma membrane; integral to membrane; integral to membrane; integral to plasma membrane; membrane
Molecular Function (4) inorganic phosphate transmembrane transporter activity; inorganic diphosphate transmembrane transporter activity; inorganic diphosphate transmembrane transporter activity; phosphate ion transmembrane transporter activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
316
647
906
949
1204
758
Cochlea GFP+ cells
434
783
1252
4164
4917
NA
Utricle GFP- cells
367
269
751
709
803
802
Cochlea GFP- cells
526
345
532
598
1000
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
609
GFP+
1485
2.44
0.157
Utricle
707
Cochlea
1455
2.06
1
Embryonic
461
Postnatal
1382
3.00
0.24
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17310673 54.13 ± 9.88 140.43 ± 33.31 [73.40] 2.59 0.253
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
3081
3193
3412
3686
No bFGF
3235
3447
3449
3545
EGF
1782
1727
1951
1820
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
3686
No bFGF
3545
0.96
1
bFGF
3686
EGF
1820
0.49
8.95e-15
No bFGF
3545
EGF
1820
0.51
2.03e-13
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1450627_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1938.07 1686.5 1962.85 1737.48 3349.19 4707.59
Replicate 1 Call P P P P P P
Replicate 2 1957.42 1859.68 2230.3 2516.56 4470.29 4277.8
Replicate 2 Call P P P P P P
Replicate 3 2133.29 1864.89 2018.11 1784.06 3155.74 3896.58
Replicate 3 Call P P P P P P
Replicate 4 1934.93 1883.4 3230 4209.91
Replicate 4 Call P P P P
Mean 2009.59 1803.69 2036.55 1980.38 3551.31 4272.97
Standard Deviation 107.56 101.52 133.71 362.6 617.82 333.95
Log2 Mean 10.97 10.82 10.99 10.94 11.78 12.06
Log2 Standard Deviation 0.08 0.08 0.09 0.25 0.23 0.11
 
Vestibular ganglion
Replicate 1 2343.34 2229.03 2158.58 2106.63 2967.95 3156.48
Replicate 1 Call P P P P P P
Replicate 2 2289.43 2210.22 2322.21 2050.35 3124.5 3069.67
Replicate 2 Call P P P P P P
Replicate 3 2282.81 2232.68 2003.09 2155.53 2950.65 3228.05
Replicate 3 Call P P P P P P
Mean 2305.19 2223.98 2161.29 2104.17 3014.37 3151.4
Standard Deviation 33.2 12.05 159.58 52.63 95.77 79.31
Log2 Mean 11.17 11.12 11.08 11.04 11.56 11.62
Log2 Standard Deviation 0.02 0.01 0.11 0.04 0.05 0.04