GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description aminolevulinic acid synthase 1
Synonyms 5-aminolevulinate synthase; succinyl-CoA: glycine C-succinyl transferase; Alas-1; ALAS-N
Chromosome 9
Genetic Map Distance 57.46 cM
RefSeq Accessions NM_020559; NP_065584
NCBI Entrez Gene 11655 at chr9:106135786-106150285 (mm9) / chr9:106233455-106247954 (mm10)
Ensembl Gene ENSMUSG00000032786
VEGA Gene OTTMUSG00000033383
MGI Gene MGI:87989
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q8VC19 5-aminolevulinate synthase, nonspecific, mitochondrial 642 0
D6RGR8 Uncharacterized protein 197 0
Q3V0B2 Putative uncharacterized protein 642 0
Pfam Domains Preseq_ALAS; Preseq_ALAS; Pfam-B_6542; Aminotran_1_2
Mouse alleles (3)
Allele Name Allele Type
Alas1tm1a(EUCOMM)Hmgu EUCOMM-projects
Alas1tm1e(EUCOMM)Hmgu EUCOMM-projects
Alas1tm1.1Mym Targeted (Reporter)
Human Homolog ALAS1 (aminolevulinate, delta-, synthase 1)
Human synonyms ALAS; ALAS3; ALASH; MIG4
Human cytoband 3p21.1
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (2)
ENSGALG00000003948 (ALAS1) encoding ENSGALP00000006285
ENSGALG00000003948 (ALAS1) encoding ENSGALP00000035503
Gene Ontology
Biological Process (5) heme biosynthetic process; biosynthetic process; porphyrin-containing compound metabolic process; tetrapyrrole biosynthetic process; metabolic process
Cellular Component (6) mitochondrial matrix; nucleus; cytoplasm; mitochondrion; mitochondrion; mitochondrion
Molecular Function (7) catalytic activity; transferase activity; transferase activity; pyridoxal phosphate binding; 5-aminolevulinate synthase activity; transferase activity; transferring nitrogenous groups; transferase activity; transferring acyl groups
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
78
40
228
13
14
98
Cochlea GFP+ cells
17
24
21
13
47
NA
Utricle GFP- cells
23
21
50
29
30
125
Cochlea GFP- cells
18
24
200
47
34
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
55
GFP+
54
0.99
1
Utricle
62
Cochlea
44
0.71
1
Embryonic
31
Postnatal
68
2.19
0.764
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17530653 20.18 ± 4.61 17.82 ± 0.48 [18.38] 0.88 0.772
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
825
786
863
877
No bFGF
698
771
694
779
EGF
544
516
543
534
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
877
No bFGF
779
0.89
1
bFGF
877
EGF
534
0.61
6.39e-6
No bFGF
779
EGF
534
0.69
0.000845
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1424126_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 310.98 501.21 632.59 492.08 1141.91 977.52
Replicate 1 Call P P P P P P
Replicate 2 355.83 478.54 663.28 563.95 1262.09 701.04
Replicate 2 Call P P P P P P
Replicate 3 373.56 514.99 657.98 617.46 665.29 809.72
Replicate 3 Call P P P P P P
Replicate 4 582.85 707.01 564.2 965.18
Replicate 4 Call P P P P
Mean 346.79 498.25 634.18 595.13 908.37 863.37
Standard Deviation 32.25 18.4 36.74 90.57 345.06 132.44
Log2 Mean 8.43 8.96 9.31 9.2 9.74 9.74
Log2 Standard Deviation 0.14 0.05 0.09 0.22 0.57 0.23
 
Vestibular ganglion
Replicate 1 352.97 780.52 715.42 670.08 1405.31 1165
Replicate 1 Call P P P P P P
Replicate 2 406.11 693.24 683.14 689.23 968.58 1295.69
Replicate 2 Call P P P P P P
Replicate 3 334.26 655.3 526.7 624.85 1009.84 1595.4
Replicate 3 Call P P P P P P
Mean 364.45 709.69 641.75 661.39 1127.91 1352.03
Standard Deviation 37.27 64.21 100.94 33.06 241.12 220.66
Log2 Mean 8.5 9.47 9.31 9.37 10.12 10.39
Log2 Standard Deviation 0.14 0.13 0.24 0.07 0.29 0.23