GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description abhydrolase domain containing 12
Synonyms 6330583M11Rik; 1500011G07Rik
Chromosome 2
Genetic Map Distance 74.74 cM
RefSeq Accessions NM_024465; NP_077785
NCBI Entrez Gene 76192 at chr2:150658251-150730467 (mm9) / chr2:150832493-150904754 (mm10)
Ensembl Gene ENSMUSG00000032046
VEGA Gene OTTMUSG00000015774
MGI Gene MGI:1923442
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q99LR1 Monoacylglycerol lipase ABHD12 398 1
D6RFU2 Uncharacterized protein 298 1
D6RI21 Uncharacterized protein 70 0
Pfam Domains Pfam-B_10797; Abhydrolase_1; Abhydrolase_2
Mouse alleles (2)
Allele Name Allele Type
Abhd12tm1a(EUCOMM)Hmgu EUCOMM-projects
Abhd12tm1e(EUCOMM)Hmgu EUCOMM-projects
Human Homolog ABHD12 (abhydrolase domain containing 12)
Human synonyms ABHD12A; BEM46L2; C20orf22; dJ965G21.2; PHARC
Human cytoband 20p11.21
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000008525 (ABD12_CHICK) encoding ENSGALP00000013877
Gene Ontology
Biological Process (3) metabolic process; metabolic process; biological_process
Cellular Component (3) integral to membrane; membrane; cellular_component
Molecular Function (3) acylglycerol lipase activity; hydrolase activity; molecular_function
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
26
106
51
61
155
84
Cochlea GFP+ cells
47
45
73
131
197
NA
Utricle GFP- cells
81
65
105
388
372
78
Cochlea GFP- cells
63
68
54
153
168
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
145
GFP+
89
0.61
0.882
Utricle
131
Cochlea
100
0.76
1
Embryonic
63
Postnatal
148
2.35
0.722
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17392730 359.88 ± 32.17 198.42 ± 73.05 [79.36] 0.55 0.494
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
549
619
643
870
No bFGF
666
759
789
806
EGF
907
893
949
916
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
870
No bFGF
806
0.93
1
bFGF
870
EGF
916
1.05
0.721
No bFGF
806
EGF
916
1.14
0.384
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000013877
Symbol ABHD12
Description Abhydrolase domain containing 12
log10 riBAQ in stereocilia (mean ± sd) -4.72 ± 0.29
log10 riBAQ in utricle (mean ± sd) -3.68 ± 0.04
Molecules per stereocilium (mean ± error with slope error) 28.18 ± 1.94
Corrected Molecules per stereocilium (mean ± sd) -34.81 ± 79.45
Stereocilium / Utricle ratio (mean ± sd) 0.09 ± 0.01
Enriched in the stereocilia (FDR < 0.05) FALSE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1417669_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 701.6 578.55 1004.01 1555.35 2394.52 2596.58
Replicate 1 Call A P P P P P
Replicate 2 714.7 760.03 1091.85 2135.8 2514.2 1628.93
Replicate 2 Call A A P P P P
Replicate 3 748.71 736.75 1284.79 1306.04 2695.78 2370.8
Replicate 3 Call P A P P P P
Replicate 4 1332.84 1196.07 2512.24 2403.56
Replicate 4 Call P P P P
Mean 721.67 691.78 1178.37 1548.32 2529.19 2249.97
Standard Deviation 24.32 98.75 156.07 419.51 124.37 425.84
Log2 Mean 9.49 9.42 10.19 10.56 11.3 11.11
Log2 Standard Deviation 0.05 0.22 0.19 0.37 0.07 0.3
 
Vestibular ganglion
Replicate 1 775.12 928.06 597.29 609.41 757.64 1362.89
Replicate 1 Call A A A A P P
Replicate 2 758.83 1004.39 631.15 558.68 945.67 1265.8
Replicate 2 Call A P A A P P
Replicate 3 720.39 927.49 369.56 609.03 875.02 1313.05
Replicate 3 Call A A A A P P
Mean 751.45 953.31 532.67 592.37 859.44 1313.91
Standard Deviation 28.1 44.23 142.27 29.18 94.98 48.55
Log2 Mean 9.55 9.9 9.02 9.21 9.74 10.36
Log2 Standard Deviation 0.05 0.07 0.42 0.07 0.16 0.05
Probe set ID: 1453367_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 370.02 267.08 387.67 711.17 802.8 794.08
Replicate 1 Call P P P P P P
Replicate 2 361.81 298.67 439.3 530.16 720.8 420.48
Replicate 2 Call P P P P P P
Replicate 3 378.9 325.59 474.16 515.97 896.92 854.25
Replicate 3 Call P P P P P P
Replicate 4 420.7 578.24 958.48 1134.22
Replicate 4 Call P P P P
Mean 370.24 297.11 430.46 583.89 844.75 800.76
Standard Deviation 8.55 29.29 36.12 88.94 104.53 293.66
Log2 Mean 8.53 8.21 8.75 9.18 9.71 9.56
Log2 Standard Deviation 0.03 0.14 0.12 0.21 0.18 0.6
 
Vestibular ganglion
Replicate 1 395.73 332.85 360.01 426.28 211.54 281.85
Replicate 1 Call P P P P P P
Replicate 2 388.12 354.57 330.39 329.71 199.1 335.56
Replicate 2 Call P P P P P P
Replicate 3 425.69 391.78 354.91 364.9 307.33 309.32
Replicate 3 Call P P P P P P
Mean 403.18 359.73 348.44 373.63 239.32 308.91
Standard Deviation 19.86 29.8 15.84 48.87 59.22 26.86
Log2 Mean 8.65 8.49 8.44 8.54 7.88 8.27
Log2 Standard Deviation 0.07 0.12 0.07 0.19 0.34 0.13