GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATP-binding cassette, sub-family B (MDR/TAP), member 9
Synonyms TAPL
Chromosome 5
Genetic Map Distance 63.36 cM
RefSeq Accessions NM_019875; NP_063928
NCBI Entrez Gene 56325 at chr5:124511866-124545807 (mm9) / chr5:124061857-124095798 (mm10)
Ensembl Gene ENSMUSG00000029408
VEGA Gene OTTMUSG00000028882
MGI Gene MGI:1861729
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q9JJ59 ATP-binding cassette sub-family B member 9 762 7
D6RFD9 Uncharacterized protein 268 6
Pfam Domains ABC_membrane; Bunya_G2; DUF607; ABC_tran; Pfam-B_11559; Pfam-B_26
Mouse alleles (3)
Allele Name Allele Type
Abcb9tm1a(KOMP)Wtsi KOMP-CSD-Project
Abcb9tm1e(KOMP)Wtsi KOMP-CSD-Project
Abcb9tm1(KOMP)Vlcg KOMP-Regeneron-Project
Human Homolog ABCB9 (ATP-binding cassette, sub-family B (MDR/TAP), member 9)
Human synonyms EST122234; TAPL
Human cytoband 12q24
Known deafness gene No
Within mapped deafness loci DFNA25; DFNA41
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000003736 (ABCB9) encoding ENSGALP00000005918
Gene Ontology
Biological Process (15) transport; transport; protein transport; peptide transport; peptide transport; peptide transport; positive regulation of T cell mediated cytotoxicity; ATP catabolic process; ATP catabolic process; ATP catabolic process; metabolic process; transmembrane transport; transmembrane transport; transmembrane transport; oligopeptide transmembrane transport
Cellular Component (9) integral to endoplasmic reticulum membrane; lysosome; TAP complex; lysosomal membrane; membrane; membrane; endoplasmic reticulum membrane; integral to membrane; plasma membrane
Molecular Function (16) ATPase activity; coupled to transmembrane movement of substances; nucleoside-triphosphatase activity; ATP binding; ATPase activity; nucleotide binding; nucleotide binding; peptide transporter activity; peptide-transporting ATPase activity; protein homodimerization activity; MHC class I protein binding; TAP2 binding; peptide antigen binding; tapasin binding; oligopeptide-transporting ATPase activity; TAP1 binding; substrate-specific transmembrane transporter activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
34
0
0
6
3
0
Cochlea GFP+ cells
0
0
5
9
6
NA
Utricle GFP- cells
1
2
0
57
15
0
Cochlea GFP- cells
0
0
2
4
10
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
8
GFP+
6
0.70
0.977
Utricle
10
Cochlea
3
0.39
1
Embryonic
5
Postnatal
8
1.69
0.431
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17452719 19.12 ± 2.22 24.72 ± 2.38 [25.29] 1.29 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
15
23
24
18
No bFGF
23
27
21
50
EGF
35
35
41
37
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
18
No bFGF
50
2.70
0.421
bFGF
18
EGF
37
1.99
0.0193
No bFGF
50
EGF
37
0.73
0.179
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416263_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 19.26 24.09 20.98 13.28 23.97 48.96
Replicate 1 Call A A A A A A
Replicate 2 19.12 23.92 11.13 17.18 37.12 2.02
Replicate 2 Call A A A A A A
Replicate 3 15.68 28.14 15.25 15.57 37.99 12.28
Replicate 3 Call A A P A A A
Replicate 4 54.28 4.73 20.71 15.02
Replicate 4 Call P A A A
Mean 18.02 25.38 25.41 12.69 29.95 19.57
Standard Deviation 2.03 2.39 19.67 5.54 8.89 20.38
Log2 Mean 4.17 4.66 4.39 3.51 4.85 3.54
Log2 Standard Deviation 0.17 0.13 0.99 0.86 0.44 1.9
 
Vestibular ganglion
Replicate 1 12.74 13.67 5.74 13.07 16.76 4.25
Replicate 1 Call A A A A A A
Replicate 2 16.35 11.77 10.79 9.92 33.84 4.18
Replicate 2 Call A A A A A A
Replicate 3 22.4 9.87 5 4.35 30.95 6.94
Replicate 3 Call A A A A A A
Mean 17.16 11.77 7.18 9.11 27.18 5.12
Standard Deviation 4.88 1.9 3.15 4.42 9.14 1.57
Log2 Mean 4.06 3.54 2.76 3.05 4.7 2.32
Log2 Standard Deviation 0.41 0.24 0.59 0.83 0.55 0.42
Probe set ID: 1416264_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 2.11 1 1.05 1 1 1
Replicate 1 Call A A A A A A
Replicate 2 1 1 1.05 1 1 15.83
Replicate 2 Call A A A A A A
Replicate 3 1 1 1 1 1 1
Replicate 3 Call A A A A A A
Replicate 4 1.46 1 1 1
Replicate 4 Call A A A A
Mean 1.37 1 1.14 1 1 4.71
Standard Deviation 0.64 0 0.21 0 0 7.42
Log2 Mean 0.36 0 0.17 0 0 1
Log2 Standard Deviation 0.62 0 0.25 0 0 1.99
 
Vestibular ganglion
Replicate 1 1 1 1 1 1 1
Replicate 1 Call A A A A A A
Replicate 2 1 1 1 1 1 1
Replicate 2 Call A A A A A A
Replicate 3 1 1 1 1 1 1
Replicate 3 Call A A A A A A
Mean 1 1 1 1 1 1
Standard Deviation 0 0 0 0 0 0
Log2 Mean 0 0 0 0 0 0
Log2 Standard Deviation 0 0 0 0 0 0
Probe set ID: 1430394_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 5.22 10.55 8.4 17.91 18.5 1
Replicate 1 Call A A A A A A
Replicate 2 8.38 14.4 11.36 3.89 10.87 4.36
Replicate 2 Call A A A A A A
Replicate 3 22.15 6.28 29.57 19.85 4.15 7.09
Replicate 3 Call A A A A A A
Replicate 4 11.01 11.38 13.43 15.85
Replicate 4 Call A A A A
Mean 11.92 10.41 15.09 13.26 11.74 7.08
Standard Deviation 9 4.06 9.75 7.22 5.97 6.36
Log2 Mean 3.31 3.3 3.73 3.49 3.36 2.23
Log2 Standard Deviation 1.06 0.6 0.79 1.08 0.93 1.68
 
Vestibular ganglion
Replicate 1 4.34 5.89 4.75 14.25 10.44 3.34
Replicate 1 Call A A A A A A
Replicate 2 15.12 17.4 21.43 6.57 11.86 3.63
Replicate 2 Call A A A A A A
Replicate 3 5.24 19.86 9.53 4.95 10.46 12.13
Replicate 3 Call A A A A A A
Mean 8.23 14.38 11.9 8.59 10.92 6.37
Standard Deviation 5.98 7.46 8.59 4.97 0.81 4.99
Log2 Mean 2.81 3.66 3.31 2.95 3.45 2.4
Log2 Standard Deviation 0.97 0.96 1.09 0.79 0.11 1.04