GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms 4833412N02Rik
Chromosome 5
Genetic Map Distance 11.57 cM
RefSeq Accessions NM_029020; NP_083296
NCBI Entrez Gene 74610 at chr5:23899974-23915765 (mm9) / chr5:24393681-24409947 (mm10)
Ensembl Gene ENSMUSG00000028973
VEGA Gene OTTMUSG00000024149
MGI Gene MGI:1351667
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
Q9CXJ4 ATP-binding cassette sub-family B member 8, mitochondrial 717 4
D3Z492 Uncharacterized protein 418 4
D3Z1J6 Uncharacterized protein 135 0
Q9JL40 ATP-binding cassette protein (Fragment) 130 0
Pfam Domains Pfam-B_6424; ABC_membrane; Pfam-B_5069; ABC_tran; Pfam-B_11559; Pfam-B_26; Pfam-B_15176
Mouse alleles (2)
Allele Name Allele Type
Abcb8tm1e(EUCOMM)Wtsi EUCOMM-projects
Abcb8tm1a(EUCOMM)Wtsi EUCOMM-projects
Human Homolog ABCB8 (ATP-binding cassette, sub-family B (MDR/TAP), member 8)
Human synonyms EST328128; M-ABC1; MABC1
Human cytoband 7q36
Known deafness gene No
Within mapped deafness loci DFNB13; OTSC2
Associated Human Disease in OMIM
None
Chicken homolog (0)
Gene Ontology
Biological Process (6) ATP catabolic process; ATP catabolic process; metabolic process; transmembrane transport; transport; transport
Cellular Component (7) nucleolus; mitochondrion; mitochondrion; mitochondrial inner membrane; membrane; integral to membrane; nucleus
Molecular Function (7) nucleotide binding; nucleotide binding; ATP binding; ATP binding; nucleoside-triphosphatase activity; ATPase activity; ATPase activity; coupled to transmembrane movement of substances
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
60
9
27
22
21
19
Cochlea GFP+ cells
18
8
8
54
44
NA
Utricle GFP- cells
14
12
8
23
28
15
Cochlea GFP- cells
10
3
8
29
19
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
15
GFP+
26
1.70
0.918
Utricle
22
Cochlea
20
0.93
1
Embryonic
17
Postnatal
23
1.37
0.951
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17435311 28.63 ± 2.12 24.97 ± 6.03 [25.45] 0.87 0.665
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1277
1335
1577
1521
No bFGF
1356
1428
1619
1581
EGF
795
924
1036
918
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1521
No bFGF
1581
1.04
1
bFGF
1521
EGF
918
0.60
5.96e-7
No bFGF
1581
EGF
918
0.58
3.64e-8
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Abcb8.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1422015_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 32.58 26.95 57.14 59.63 16.63 29.52
Replicate 1 Call A A A A A A
Replicate 2 38.76 53.4 35.32 33.97 54.71 10.7
Replicate 2 Call A A A A A A
Replicate 3 66.31 32.09 69.09 40.16 17.77 19.92
Replicate 3 Call A A P A A A
Replicate 4 39.48 39.35 7.84 21.31
Replicate 4 Call A A A A
Mean 45.88 37.48 50.26 43.28 24.24 20.36
Standard Deviation 17.96 14.02 15.72 11.24 20.79 7.71
Log2 Mean 5.45 5.17 5.6 5.4 4.24 4.26
Log2 Standard Deviation 0.53 0.51 0.45 0.35 1.16 0.61
 
Vestibular ganglion
Replicate 1 40.61 34.4 14.13 31.98 29.16 20.14
Replicate 1 Call A A A A A A
Replicate 2 50.8 38.74 37.99 22.25 39.78 27.73
Replicate 2 Call A A A A A A
Replicate 3 29.14 32.68 24.57 18.73 14.91 32.52
Replicate 3 Call A A A A A A
Mean 40.18 35.27 25.56 24.32 27.95 26.8
Standard Deviation 10.84 3.12 11.96 6.86 12.48 6.24
Log2 Mean 5.29 5.14 4.56 4.57 4.69 4.72
Log2 Standard Deviation 0.4 0.13 0.72 0.39 0.72 0.35
Probe set ID: 1423713_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 20.66 30.83 33.15 29.32 17.07 31.22
Replicate 1 Call A A A A A A
Replicate 2 16.7 7.05 55.24 14.96 33.12 6.4
Replicate 2 Call A A P A A A
Replicate 3 15.06 7.28 57.02 26.37 5.87 35.6
Replicate 3 Call A A P A A A
Replicate 4 51.58 24.66 32.7 21.05
Replicate 4 Call A A A A
Mean 17.47 15.05 49.25 23.83 22.19 23.57
Standard Deviation 2.88 13.66 10.97 6.22 13.2 12.97
Log2 Mean 4.11 3.54 5.59 4.53 4.18 4.3
Log2 Standard Deviation 0.23 1.22 0.36 0.43 1.17 1.13
 
Vestibular ganglion
Replicate 1 3.82 22.29 6.59 1 16.91 1
Replicate 1 Call A A A A A A
Replicate 2 9.67 25.57 13.16 1.23 1.57 1
Replicate 2 Call A A A A A A
Replicate 3 5.84 22.54 2.95 5.9 10.17 6.55
Replicate 3 Call A A A A A A
Mean 6.44 23.47 7.57 2.71 9.55 2.85
Standard Deviation 2.97 1.83 5.17 2.77 7.69 3.2
Log2 Mean 2.58 4.55 2.67 0.95 2.69 0.9
Log2 Standard Deviation 0.67 0.11 1.08 1.4 1.81 1.57