GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATP-binding cassette, sub-family B (MDR/TAP), member 7
Synonyms Abc7
Chromosome X
Genetic Map Distance 46.58 cM
RefSeq Accessions NM_009592; NP_033722
NCBI Entrez Gene 11306 at chrX:101475904-101609185 (mm9) / chr0:104280565-104413846 (mm10)
Ensembl Gene ENSMUSG00000031333
VEGA Gene OTTMUSG00000018115
MGI Gene MGI:109533
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q61102 ATP-binding cassette sub-family B member 7, mitochondrial 752 5
A2AC46 ATP-binding cassette, sub-family B (MDR/TAP), member 7 752 5
Pfam Domains ABC_membrane; DUF697; Pfam-B_5069; ABC_tran; Pfam-B_11559; Pfam-B_26
Mouse alleles (4)
Allele Name Allele Type
Abcb7tm1a(EUCOMM)Hmgu EUCOMM-projects
Abcb7tm1e(EUCOMM)Hmgu EUCOMM-projects
Abcb7tm1.1Mdf Targeted (knock-out)
Abcb7tm1Mdf Targeted (Floxed/Frt)
Human Homolog ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7)
Human synonyms ABC7; ASAT; Atm1p; EST140535
Human cytoband Xq13.3
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000007788 (ABCB7) encoding ENSGALP00000012615
Gene Ontology
Biological Process (7) cellular iron ion homeostasis; transmembrane transport; ATP catabolic process; ATP catabolic process; metabolic process; transport; transport
Cellular Component (7) mitochondrion; mitochondrial inner membrane; mitochondrial inner membrane; integral to membrane; cytoplasm; membrane; mitochondrion
Molecular Function (7) nucleotide binding; nucleotide binding; ATP binding; ATP binding; ATPase activity; coupled to transmembrane movement of substances; nucleoside-triphosphatase activity; ATPase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
1210
1381
1110
1783
1812
1771
Cochlea GFP+ cells
2318
895
950
1104
1032
NA
Utricle GFP- cells
891
936
736
683
614
409
Cochlea GFP- cells
800
777
570
484
462
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
669
GFP+
1397
2.09
0.46
Utricle
1111
Cochlea
939
0.85
1
Embryonic
1151
Postnatal
966
0.84
0.993
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17543852 57.50 ± 8.50 56.48 ± 9.02 [37.63] 0.98 0.974
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
710
657
522
548
No bFGF
652
549
478
511
EGF
777
748
632
719
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
548
No bFGF
511
0.93
1
bFGF
548
EGF
719
1.31
0.0368
No bFGF
511
EGF
719
1.41
0.00555
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1419931_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 179.57 257.65 203.31 165.94 592.27 441.61
Replicate 1 Call P P P A P P
Replicate 2 192.43 220.08 154.07 157.62 309.12 373.73
Replicate 2 Call P P A P P P
Replicate 3 182.41 279.99 228.22 308.05 439 637.51
Replicate 3 Call P P A P P P
Replicate 4 186.91 243.72 111.65 481.8
Replicate 4 Call P P A P
Mean 184.8 252.57 193.13 218.83 363.01 483.66
Standard Deviation 6.76 30.28 31.09 71 203.65 111.84
Log2 Mean 7.53 7.97 7.58 7.72 8.27 8.89
Log2 Standard Deviation 0.05 0.18 0.24 0.46 1.05 0.32
 
Vestibular ganglion
Replicate 1 147.72 166.81 181.73 264.7 323.94 345.42
Replicate 1 Call P P P P P P
Replicate 2 170.85 158.88 207.13 239.54 255.55 341.06
Replicate 2 Call P P P M P P
Replicate 3 129.15 184.63 332.55 235.7 324.31 347.66
Replicate 3 Call P P P A P P
Mean 149.24 170.11 240.47 246.65 301.27 344.71
Standard Deviation 20.89 13.19 80.75 15.75 39.59 3.36
Log2 Mean 7.21 7.41 7.86 7.94 8.23 8.43
Log2 Standard Deviation 0.2 0.11 0.46 0.09 0.2 0.01
Probe set ID: 1427490_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 309.13 251.41 86.74 116.67 221.81 191.92
Replicate 1 Call P P P P P P
Replicate 2 314.98 234.08 98.99 162.12 124.19 53.5
Replicate 2 Call P P P P P A
Replicate 3 304.15 274.72 116.13 97.92 202.74 114.83
Replicate 3 Call P P P P P P
Replicate 4 124.82 116.55 111.01 109.17
Replicate 4 Call P P P P
Mean 309.42 253.4 106.67 123.32 164.94 117.36
Standard Deviation 5.42 20.39 17.08 27.33 55.47 56.89
Log2 Mean 8.27 7.98 6.72 6.92 7.3 6.73
Log2 Standard Deviation 0.03 0.12 0.24 0.3 0.5 0.76
 
Vestibular ganglion
Replicate 1 119.21 113.81 200.74 252.41 262.49 186.01
Replicate 1 Call P P P P P P
Replicate 2 132.12 128.02 193.53 161.95 238.94 226.2
Replicate 2 Call P P P P P P
Replicate 3 150.57 131.88 341.26 168.24 236.18 203.32
Replicate 3 Call P P P P P P
Mean 133.97 124.57 245.18 194.2 245.87 205.18
Standard Deviation 15.76 9.52 83.29 50.51 14.46 20.16
Log2 Mean 7.06 6.96 7.89 7.57 7.94 7.68
Log2 Standard Deviation 0.17 0.11 0.46 0.35 0.08 0.14
Probe set ID: 1435006_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 3779.71 3404.03 2212.66 2046.92 1994.15 1302.52
Replicate 1 Call P P P P P P
Replicate 2 3819.72 3955.53 1153.61 1745.44 1954.66 1047.83
Replicate 2 Call P P P P P P
Replicate 3 3998.47 3954.99 1415.56 1913.6 1400.48 1809.71
Replicate 3 Call P P P P P P
Replicate 4 1013.39 2215.77 987.5 1674.85
Replicate 4 Call P P P P
Mean 3865.97 3771.52 1448.81 1980.43 1584.2 1458.73
Standard Deviation 116.48 318.25 535.82 199.58 481.35 347.92
Log2 Mean 11.92 11.88 10.43 10.95 10.57 10.48
Log2 Standard Deviation 0.04 0.13 0.49 0.15 0.48 0.36
 
Vestibular ganglion
Replicate 1 3638.25 3011.79 2798.02 3251.45 3695.23 3636.08
Replicate 1 Call P P P P P P
Replicate 2 3381.8 3050.83 2846.76 2635.72 3543.46 3785.32
Replicate 2 Call P P P P P P
Replicate 3 3361.22 2872.54 3092.24 2799.39 3824.38 3978.71
Replicate 3 Call P P P P P P
Mean 3460.42 2978.39 2912.34 2895.52 3687.69 3800.04
Standard Deviation 154.35 93.72 157.69 318.92 140.61 171.79
Log2 Mean 11.76 11.54 11.51 11.49 11.85 11.89
Log2 Standard Deviation 0.06 0.05 0.08 0.16 0.06 0.07