GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATP-binding cassette, sub-family B (MDR/TAP), member 6
Synonyms 1200005B17Rik
Chromosome 1
Genetic Map Distance 38.62 cM
RefSeq Accessions NM_023732; NP_076221
NCBI Entrez Gene 74104 at chr1:75168214-75176857 (mm9) / chr1:75171640-75180283 (mm10)
Ensembl Gene ENSMUSG00000026198
VEGA Gene OTTMUSG00000034720
MGI Gene MGI:1921354
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q9DC29 ATP-binding cassette sub-family B member 6, mitochondrial 842 9
O70322 ABC transporter (Fragment) 76 0
Pfam Domains ABC_membrane; ABC_tran; Pfam-B_11559; Pfam-B_26
Mouse alleles (2)
Allele Name Allele Type
Abcb6tm1a(KOMP)Wtsi KOMP-CSD-Project
Abcb6tm1e(KOMP)Wtsi KOMP-CSD-Project
Human Homolog ABCB6 (ATP-binding cassette, sub-family B (MDR/TAP), member 6)
Human synonyms ABC; ABC14; MTABC3; PRP; umat
Human cytoband 2q36
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (2)
ENSGALG00000011648 (ABCB6) encoding ENSGALP00000019014
ENSGALG00000011648 (ABCB6) encoding ENSGALP00000037478
Gene Ontology
Biological Process (10) ATP catabolic process; ATP catabolic process; ATP catabolic process; metabolic process; transport; transmembrane transport; detoxification of cadmium ion; cadmium ion transmembrane transport; porphyrin-containing compound biosynthetic process; heme transport
Cellular Component (11) integral to mitochondrial outer membrane; vacuolar membrane; integral to membrane; mitochondrial envelope; mitochondrion; mitochondrion; mitochondrion; mitochondrial outer membrane; membrane; Golgi apparatus; plasma membrane
Molecular Function (9) heme binding; nucleoside-triphosphatase activity; ATPase activity; coupled to transmembrane movement of substances; ATPase activity; ATP binding; nucleotide binding; nucleotide binding; heme-transporting ATPase activity; efflux transmembrane transporter activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
121
41
95
79
98
189
Cochlea GFP+ cells
29
26
58
109
125
NA
Utricle GFP- cells
65
17
23
100
136
15
Cochlea GFP- cells
35
23
14
57
14
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
45
GFP+
88
1.93
0.771
Utricle
82
Cochlea
49
0.60
1
Embryonic
45
Postnatal
79
1.77
0.94
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17224476 27.35 ± 7.17 23.55 ± 3.59 [31.30] 0.86 0.779
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
846
766
976
797
No bFGF
1048
1096
1194
1141
EGF
1228
1234
1451
1304
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
797
No bFGF
1141
1.43
1
bFGF
797
EGF
1304
1.64
2.55e-5
No bFGF
1141
EGF
1304
1.14
0.32
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1422524_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 989.35 1214.85 968.01 1316.06 1855.3 1529.06
Replicate 1 Call P P P P P P
Replicate 2 953.52 1125.62 1292.38 1428.98 1480.73 1976.27
Replicate 2 Call P P P P P P
Replicate 3 920.53 1043.54 1167.7 1216.43 1654.98 1628.38
Replicate 3 Call P P P P P P
Replicate 4 1405.53 1279.57 1696.27 1634.03
Replicate 4 Call P P P P
Mean 954.47 1128 1208.41 1310.26 1671.82 1691.94
Standard Deviation 34.42 85.68 187.4 89.21 153.91 195.59
Log2 Mean 9.9 10.14 10.23 10.35 10.7 10.72
Log2 Standard Deviation 0.05 0.11 0.23 0.1 0.13 0.16
 
Vestibular ganglion
Replicate 1 890.83 1281.4 1327 1097.98 1422.36 1059.8
Replicate 1 Call P P P P P P
Replicate 2 880.04 1050.91 1271.59 1276.57 1123.42 1265.8
Replicate 2 Call P P P P P P
Replicate 3 950.83 1119.93 1266.3 1318.73 1311.81 1166.44
Replicate 3 Call P P P P P P
Mean 907.23 1150.75 1288.3 1231.09 1285.86 1164.01
Standard Deviation 38.14 118.29 33.62 117.19 151.15 103.02
Log2 Mean 9.82 10.16 10.33 10.26 10.32 10.18
Log2 Standard Deviation 0.06 0.15 0.04 0.14 0.17 0.13