GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms 9230106F14Rik
Chromosome 12
Genetic Map Distance 63.48 cM
RefSeq Accessions NM_029961; NP_084237
NCBI Entrez Gene 77706 at chr12:120106297-120204894 (mm9) / chr12:118867616-118966542 (mm10)
Ensembl Gene ENSMUSG00000072791
VEGA Gene OTTMUSG00000036992
MGI Gene MGI:1924956
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
B5X0E4 ATP-binding cassette sub-family B member 5 variant 1255 9
Q3UT27 Putative uncharacterized protein 417 3
B5X0E3 ATP-binding cassette sub-family B member 5 variant 134 2
Q9CTU3 Putative uncharacterized protein (Fragment) 262 2
Pfam Domains ABC_membrane; ABC_tran; Pfam-B_11559; Pfam-B_26; Pfam-B_15176; ABC_membrane; DUF3703; ABC_tran; Pfam-B_11559; Pfam-B_26
Mouse alleles (1)
Allele Name Allele Type
Abcb5tm1(KOMP)Vlcg KOMP-Regeneron-Project
Human Homolog ABCB5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5)
Human synonyms ABCB5alpha; ABCB5beta; EST422562
Human cytoband 7p21.1
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (0)
Gene Ontology
Biological Process (4) transmembrane transport; transmembrane transport; regulation of membrane potential; ATP catabolic process
Cellular Component (5) integral to membrane; intercellular canaliculus; integral to plasma membrane; Golgi membrane; apical plasma membrane
Molecular Function (4) ATP binding; nucleotide binding; efflux transmembrane transporter activity; ATPase activity; coupled to transmembrane movement of substances
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
17
72
3
0
0
39
Cochlea GFP+ cells
1
37
2
1
1
NA
Utricle GFP- cells
1
49
24
5
1
0
Cochlea GFP- cells
3
27
48
0
4
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
15
GFP+
16
1.06
1
Utricle
18
Cochlea
12
0.71
1
Embryonic
26
Postnatal
9
0.37
0.804
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17284808 7.88 ± 0.01 9.02 ± 0.98 [7.80] 1.14 0.515
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
1
1
0
No bFGF
2
2
2
1
EGF
0
1
3
1
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
0
No bFGF
1
3.15
1
bFGF
0
EGF
1
3.03
0.44
No bFGF
1
EGF
1
0.96
1
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Abcb5.
Auditory and Vestibular Ganglion Neurons
No probes available for Abcb5 on Affymetrix MOE430_2.0 GeneChip.