GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms mdr; Pgy1; Abcb1; Mdr1b; Mdr1; Pgy-1
Chromosome 5
Genetic Map Distance 3.43 cM
RefSeq Accessions NM_011075; NP_035205
NCBI Entrez Gene 18669 at chr5:8798147-8866314 (mm9) / chr5:8798147-8866315 (mm10)
Ensembl Gene ENSMUSG00000028970
VEGA Gene
MGI Gene MGI:97568
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
P06795 Multidrug resistance protein 1 1276 10
B2RUR3 ATP-binding cassette, sub-family B (MDR/TAP), member 1B 1276 10
O88865 Multidrug resistant protein (Fragment) 25 0
Pfam Domains
Mouse alleles (4)
Allele Name Allele Type
Abcb1btm1a(EUCOMM)Hmgu EUCOMM-projects
Abcb1btm1e(EUCOMM)Hmgu EUCOMM-projects
Abcb1btm1Bor Targeted (knock-out)
Abcb1btm2Bor Targeted (knock-out)
Human Homolog None
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (4)
ENSGALG00000008912 (O93437_CHICK) encoding ENSGALP00000014477
ENSGALG00000008912 (O93437_CHICK) encoding ENSGALP00000037427
ENSGALG00000023271 (ABCB1) encoding ENSGALP00000014451
ENSGALG00000023271 (ABCB1) encoding ENSGALP00000037453
Gene Ontology
Biological Process (7) establishment of endothelial blood-brain barrier; transmembrane transport; transport; drug transmembrane transport; drug transport; response to drug; ATP catabolic process
Cellular Component (8) intercellular canaliculus; apical plasma membrane; apical plasma membrane; integral to membrane; Golgi membrane; Golgi membrane; membrane; mitochondrion
Molecular Function (11) ATP binding; ATPase activity; coupled to transmembrane movement of substances; nucleotide binding; nucleotide binding; hydrolase activity; nucleoside-triphosphatase activity; xenobiotic-transporting ATPase activity; transporter activity; ATPase activity; drug transmembrane transporter activity; ATP binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
8
0
6
6
0
0
Cochlea GFP+ cells
0
3
0
0
0
NA
Utricle GFP- cells
3
10
6
0
1
0
Cochlea GFP- cells
1
5
0
1
16
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
4
GFP+
2
0.59
0.639
Utricle
3
Cochlea
3
0.81
1
Embryonic
4
Postnatal
3
0.74
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17434555 4.06 ± 0.09 4.78 ± 0.75 [3.54] 1.18 0.515
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
396
378
340
493
No bFGF
187
156
145
154
EGF
114
112
103
110
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
493
No bFGF
154
0.31
0.00437
bFGF
493
EGF
110
0.22
1.34e-35
No bFGF
154
EGF
110
0.71
0.0466
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1418872_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 36.31 63.95 42.98 53.22 346.02 440.4
Replicate 1 Call A A A A P P
Replicate 2 57.18 43.9 47.86 178.65 138.95 290.75
Replicate 2 Call A A A P P P
Replicate 3 36.19 50.13 18.54 34.55 104.9 103.38
Replicate 3 Call A P A A P M
Replicate 4 59.52 65.92 162 224.49
Replicate 4 Call A A P P
Mean 43.23 52.66 42.23 83.09 187.97 264.76
Standard Deviation 12.08 10.26 17.25 65 107.95 140.46
Log2 Mean 5.4 5.7 5.28 6.09 7.4 7.87
Log2 Standard Deviation 0.38 0.28 0.74 1 0.74 0.88
 
Vestibular ganglion
Replicate 1 20.72 28.57 309.24 129.78 299.54 109.71
Replicate 1 Call A A P A P A
Replicate 2 49.12 32.05 232.13 158.84 146.75 105.19
Replicate 2 Call A A A A A P
Replicate 3 39.47 29.87 272.87 122.01 275.57 134.06
Replicate 3 Call A A P A A P
Mean 36.44 30.16 271.41 136.88 240.62 116.32
Standard Deviation 14.44 1.76 38.58 19.41 82.17 15.53
Log2 Mean 5.1 4.91 8.07 7.09 7.84 6.85
Log2 Standard Deviation 0.65 0.08 0.21 0.2 0.56 0.19
Probe set ID: 1446701_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 110.11 159.25 169.75 169.85 143.64 88.52
Replicate 1 Call A A A A A A
Replicate 2 123.51 165 172.66 142.23 173.78 130.75
Replicate 2 Call A A A A A A
Replicate 3 155.3 144.61 204.87 191.45 99.7 175.11
Replicate 3 Call A A A A A M
Replicate 4 174.53 217.86 144.68 156.95
Replicate 4 Call P A A A
Mean 129.64 156.29 180.45 180.35 140.45 137.83
Standard Deviation 23.21 10.51 16.4 32.11 30.55 37.58
Log2 Mean 7 7.29 7.49 7.48 7.11 7.06
Log2 Standard Deviation 0.25 0.1 0.13 0.26 0.34 0.43
 
Vestibular ganglion
Replicate 1 141.7 150.39 118.8 166.36 147.88 161.81
Replicate 1 Call A A A A A P
Replicate 2 155.73 150.75 135.61 159.89 117.74 180.82
Replicate 2 Call A P A A A A
Replicate 3 122.82 156.71 184.14 154.76 161.74 144.85
Replicate 3 Call A A A A A A
Mean 140.08 152.62 146.18 160.34 142.45 162.49
Standard Deviation 16.51 3.55 33.93 5.81 22.5 17.99
Log2 Mean 7.12 7.25 7.17 7.32 7.14 7.34
Log2 Standard Deviation 0.17 0.03 0.32 0.05 0.24 0.16