GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms ABC-me
Chromosome 8
Genetic Map Distance 72.31 cM
RefSeq Accessions NM_019552; NP_062425
NCBI Entrez Gene 56199 at chr8:126476359-126507022 (mm9) / chr8:123952459-123983122 (mm10)
Ensembl Gene ENSMUSG00000031974
VEGA Gene OTTMUSG00000031206
MGI Gene MGI:1860508
Mouse Protein (1)
UniProt ID Description Length (AA) Predicted # TMs
Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial 715 5
Pfam Domains Pfam-B_9348; Pfam-B_6424; ABC_membrane; Pfam-B_5069; ABC_tran; Pfam-B_11559; Pfam-B_26
Mouse alleles (4)
Allele Name Allele Type
Abcb10tm1a(EUCOMM)Wtsi EUCOMM-projects
Abcb10tm1e(EUCOMM)Wtsi EUCOMM-projects
Abcb10tm1e(EUCOMM)Hmgu EUCOMM-projects
Abcb10tm1(KOMP)Vlcg KOMP-Regeneron-Project
Human Homolog ABCB10 (ATP-binding cassette, sub-family B (MDR/TAP), member 10)
Human synonyms EST20237; M-ABC2; MTABC2
Human cytoband 1q42.13
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000011096 (ABCB10) encoding ENSGALP00000018057
Gene Ontology
Biological Process (8) transmembrane transport; transmembrane transport; oligopeptide transmembrane transport; ATP catabolic process; ATP catabolic process; transport; transport; metabolic process
Cellular Component (7) mitochondrial inner membrane; mitochondrial inner membrane; integral to mitochondrial membrane; integral to membrane; membrane; mitochondrion; mitochondrion
Molecular Function (10) transporter activity; ATPase activity; coupled to transmembrane movement of substances; protein homodimerization activity; oligopeptide-transporting ATPase activity; nucleoside-triphosphatase activity; ATPase activity; nucleotide binding; nucleotide binding; ATP binding; ATP binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
880
1017
634
548
960
281
Cochlea GFP+ cells
1015
1378
1262
771
1126
NA
Utricle GFP- cells
1435
1057
1154
2299
1210
865
Cochlea GFP- cells
1433
1093
1134
985
753
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
1220
GFP+
897
0.74
1
Utricle
1028
Cochlea
1095
1.06
1
Embryonic
1164
Postnatal
999
0.86
0.979
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17514033 17.81 ± 0.56 17.15 ± 2.60 [22.57] 0.96 0.73
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
660
655
579
626
No bFGF
623
624
676
801
EGF
527
622
546
565
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
626
No bFGF
801
1.28
1
bFGF
626
EGF
565
0.90
0.492
No bFGF
801
EGF
565
0.71
0.00184
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416402_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1585.51 1805.44 1903.28 1279.54 815.83 700.69
Replicate 1 Call P P P P P P
Replicate 2 1640.93 1899.15 1769.66 819.22 1095.28 855.56
Replicate 2 Call P P P P P P
Replicate 3 1707.63 1916.95 1689.8 1592.21 738.92 862.99
Replicate 3 Call P P P P P M
Replicate 4 1507.7 1693.25 745.7 921.05
Replicate 4 Call A P A A
Mean 1644.69 1873.85 1717.61 1346.06 848.93 835.07
Standard Deviation 61.15 59.91 165.35 392.9 167.87 94.25
Log2 Mean 10.68 10.87 10.74 10.34 9.71 9.7
Log2 Standard Deviation 0.05 0.05 0.14 0.47 0.27 0.17
 
Vestibular ganglion
Replicate 1 1937.36 1987.45 1545.47 1490.3 1331.51 1669.93
Replicate 1 Call P P P P P P
Replicate 2 1846.08 2076.14 1777.7 1414.15 1506.26 1508.29
Replicate 2 Call P P P P P P
Replicate 3 1857.12 2139.82 1665.27 1426.38 1572.78 1553.85
Replicate 3 Call P P P P P P
Mean 1880.19 2067.8 1662.81 1443.61 1470.18 1577.36
Standard Deviation 49.82 76.53 116.13 40.89 124.62 83.34
Log2 Mean 10.88 11.01 10.7 10.5 10.52 10.62
Log2 Standard Deviation 0.04 0.05 0.1 0.04 0.12 0.08
Probe set ID: 1416403_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 113.94 124.56 140.03 146.53 121.4 99.42
Replicate 1 Call P P P P P M
Replicate 2 122.25 114.96 183.28 148.27 134.14 146.5
Replicate 2 Call P A P A M A
Replicate 3 118.37 71.47 185.19 135.96 112.17 177.37
Replicate 3 Call P A P P A P
Replicate 4 170.4 144.19 126.95 124.95
Replicate 4 Call P P A A
Mean 118.19 103.66 169.73 143.74 123.67 137.06
Standard Deviation 4.16 28.29 20.86 5.45 9.27 33.05
Log2 Mean 6.88 6.65 7.4 7.17 6.95 7.07
Log2 Standard Deviation 0.05 0.43 0.19 0.06 0.11 0.35
 
Vestibular ganglion
Replicate 1 120.63 113.63 92.61 103.14 151.87 168.41
Replicate 1 Call P P A A A P
Replicate 2 128.63 111.68 106.24 113.48 146.33 155.34
Replicate 2 Call P P A A A P
Replicate 3 139.53 89.01 114.68 124.29 101.12 167.35
Replicate 3 Call P P A A A P
Mean 129.6 104.77 104.51 113.64 133.11 163.7
Standard Deviation 9.49 13.69 11.14 10.58 27.84 7.26
Log2 Mean 7.02 6.7 6.7 6.82 7.03 7.35
Log2 Standard Deviation 0.11 0.2 0.16 0.13 0.32 0.06
Probe set ID: 1454265_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 12.34 3.56 15.45 12.04 2.61 7.64
Replicate 1 Call A A P A A A
Replicate 2 9.25 14.07 6.58 1 2.53 7.07
Replicate 2 Call A A A A A A
Replicate 3 9.28 14.05 10.84 5.62 5.84 16.77
Replicate 3 Call A A A A A A
Replicate 4 13.67 18.13 3.93 13.18
Replicate 4 Call A A A A
Mean 10.29 10.56 11.64 9.2 3.73 11.17
Standard Deviation 1.78 6.06 3.87 7.48 1.55 4.64
Log2 Mean 3.35 3.15 3.47 2.57 1.81 3.39
Log2 Standard Deviation 0.24 1.14 0.54 1.85 0.57 0.61
 
Vestibular ganglion
Replicate 1 3.72 9.9 6.18 11.68 26.35 14.43
Replicate 1 Call A A A A A P
Replicate 2 3.65 1.49 17.21 20 13.36 15.76
Replicate 2 Call A A A A A P
Replicate 3 13.01 16.18 6.77 8.44 3.94 21.59
Replicate 3 Call A P A A A A
Mean 6.79 9.19 10.05 13.37 14.55 17.26
Standard Deviation 5.38 7.37 6.2 5.96 11.25 3.81
Log2 Mean 2.49 2.63 3.16 3.65 3.48 4.09
Log2 Standard Deviation 1.05 1.82 0.82 0.63 1.39 0.31